The impact of the time interval onin-vitrofertilisation success after failure of the first attempt

Abstract

The aim of this study was to identify the optimal time interval for in-vitro fertilisation that would increase treatment success after failure of the first attempt. This retrospective study evaluated 454 consecutive cycles of 227 infertile women who had two consecutive attempts within a 6-month period at an IVF centre. Data were collected on duration of stimulation, consumption of gonadotropin, numbers of retrieved oocytes, mature oocytes, fertilised eggs, good quality embryos on day 3/5 following oocyte retrieval and clinical and ongoing pregnancy. There were significant increases in clinical pregnancy rates at 2-, 3- and 4-month intervals. The maximum increase was after two menstrual cycles (p = 0.001). The highest rate of ongoing pregnancy was in women that had the second attempt after the next menstrual cycle following failure of IVF (27.2%). After IVF failure, initiating the next attempt within 2-4 months increases the clinical pregnancy rates.

Meta‐analysis of the embryo freezing transfer interval

“…Finally, 17 studies were screened and 12 were included in the meta‐analysis. The characteristics of studies excluded 30‐34 are listed in Table S2. All the studies included scored well on the NOS, achieving a score of between 7 and 9 (Table S1).…”

Medium-Based Noninvasive Preimplantation Genetic Diagnosis for Human α-Thalassemias-SEA

“…IVF offers personal approaches for couples according to their specific infertility problems and may include PGD, single-embryo transfer, blastocyst transfer, and optimization of uterine receptivity. 25 PGD is recommended for couples at risk for specific inherited disorders, such as α-thalassemias –SEA carriers. To the best of our knowledge, this is the first study to introduce a new, noninvasive medium-based testing to screen healthy embryos from α-thalassemias –SEA carriers who undergo IVF.…”