“…Unfortunately, the majority of the patients, up to 87% of them, with newly diagnosed neovascular AMD accordingly to Freund et al 26 , do not meet the criteria for laser photocoagulation because the CNV is too large, occult or ill defined 14,15,27,28 . Furthermore, among those patients with extrafoveal lesion treated with laser photocoagulation, up to 54% suffered recurrence (defined by leakage of fluorescein at the periphery of the laser scar later than 6 weeks after treatment) after a 5-year follow-up 18, 30, 31. In the juxtafoveal and subfoveal groups of patients similarly recurrence occurred in 47 and 35% respectively 27,32,34 . Nowadays, it is becoming evident that the available techniques for laser photocoagulation of choroidal neovascular membranes due to AMD will not have a major impact on blindness due to AMD, despite early expectations 24,27,34,35 .…”