The impact of the latest classification system of benign vulvar diseases on the management of women with chronic vulvar pruritus

Kelekci, Kiymet Handan; Adamhasan, Fulya; Gençdal, Servet; Sayar, Hamide; Kelekçi, Sefa

doi:10.4103/0378-6323.79698

Cited by 5 publications

(12 citation statements)

References 8 publications

(10 reference statements)

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“…The term lichen sclerosus (and/ or atrophicus) should no longer be used, as forms of lichen sclerosus are not all atrophic. When there is coexistence of squamous cell hyperplasia, it is characterized as "mixed squamous cell hyperplasia and lichen sclerosus" [26][27][28][29][30][31][32].…”

Section: Lichen Sclerosusmentioning

confidence: 99%

“…Over time, plugs and craters may disappear by dropping a smooth, often porcelain plaque, and they rarely show up. Thus, the skin appears white and thin, although it may be present in SCH [26][27][28][29][30][31][32]. Originally, lichen sclerosus may have a bubbling consistency and is characterized by edema of the prepuce clitoris and telangiectasia of labia and purpura.…”

Section: Lichen Sclerosusmentioning

confidence: 99%

“…However, there may be lesions in the forehead of the skin, which will lead to its constriction. Perianal lesions are described in 30% of cases [26][27][28][29][30][31][32].…”

Section: Lichen Sclerosusmentioning

confidence: 99%

“…Itching is intense during the night and may be so intense that it stops sleeping. Discomfort occurs when there is erosion, stretch marks, or narrowing of vaginal orifice [26][27][28][29][30][31][32]. Some women are asymptomatic, and LS is a random finding.…”

Section: Lichen Sclerosusmentioning

confidence: 99%

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Depigmentation’s Disorders of the Vulva, Clinical Management

Tsikouras¹,

Anthoulaki²,

Deftereou³

et al. 2019

Depigmentation

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The cancer of the vulva is a rare disease with a positive association to poor developing countries. However, the incidence of vulvar cancer in situ nearly doubled in the last two decades and remained relatively stable. The main reason for this increased incidence of vulvar intraepithelial neoplasia (VIN) in women younger than 45 years is due to changes in sexual behavior, first intercourse at early age, multiple sexual partners, and sexually transmitted diseases that were increasing progressively. Furthermore, it is strongly associated with smoking and the increased incidence of HPV infection. The occurrence of early symptoms of VINlike pruritus vulvae, pain, and lichen sclerosus led to early diagnosis to perform the adequate treatment. VIN tends to appear multifocal, while most invasive cancers are unilateral located and appeared with well-circumscribed lesions.

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Section: Lichen Sclerosusmentioning

confidence: 99%

Section: Lichen Sclerosusmentioning

confidence: 99%

“…However, there may be lesions in the forehead of the skin, which will lead to its constriction. Perianal lesions are described in 30% of cases [26][27][28][29][30][31][32].…”

Section: Lichen Sclerosusmentioning

confidence: 99%

Section: Lichen Sclerosusmentioning

confidence: 99%

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Depigmentation’s Disorders of the Vulva, Clinical Management

Tsikouras¹,

Anthoulaki²,

Deftereou³

et al. 2019

Depigmentation

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“…The management principles are those applicable to most vulvar diseases and include: patient’s education and environmental modification; treatment of any secondary, moderate-to-severe, infection; and, finally, a potent topical steroid, recommended initially once a day (for maximum 1 month) until symptoms disappear. The application rate can be reduced (for example, every second day or three times a week) as symptoms improve 3. Because of the chronic course of genital dermatitis and the potential side effects associated with potent topical steroids, alternative, well-tolerated therapies are required 4.…”

Section: Introductionmentioning

confidence: 99%

Post-steroid management of chronic vulvar itching with a topical formula containing natural anti-itching and anti-inflammatory actives

Pierro

Maio²,

Paola³

et al. 2013

IJWH

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AimTo determine whether use of a topical, nonsteroidal, anti-inflammatory, and anti-itching formula was able to preserve the absence of symptoms, mainly itching and burning, induced by an earlier and relatively short treatment with topical steroids in women diagnosed with vulvar dermatitis or lichen simplex.MethodsNinety-six subjects (36 with contact dermatitis, 29 with allergic dermatitis, 31 with lichen simplex) were enrolled in the study. All participants were first treated with topical mometasone furoate (MF) 0.1%. When the symptoms disappeared, they were treated either with Zantogin®, a multicomponent topical formula containing anti-inflammatory and anti-itching natural actives, or a control cream for 60 days.ResultsThe study demonstrated that, in about 85% of the participants treated with Zantogin®, symptoms disappeared completely, and only 15% had to resort to MF as needed, with an average use of about three applications per subject (in total). In the placebo group, approximately 90% of participants had to resort to MF as needed, with an average use per person of more than 16 applications in 60 days.ConclusionOur study demonstrates that, following use of a topical steroid, symptoms such as burning and itching can be validly controlled with subsequent and longer therapy with a herbal topical formula, Zantogin®, which is able to properly counteract itching and inflammation, prevent symptom relapse, and avoid the typical side effects associated with prolonged use of topical steroids.

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