The impact of the COVID-19 pandemic on patients with primary Sjögren syndrome

Serban, Augustin; Mihai, Ancuta; Dima, Alina; Balaban, Daniel Vasile; Jinga, Mariana; Jurcuţ, Ciprian

doi:10.1007/s00296-021-04967-4

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…This may reflect the overall toil and stress felt across the general population since the outbreak of the virus. Such feelings of uncertainty, anxiety and fear have been reported by authors amongst patients with pSS and rheumatic diseases 14 , 15 .…”

Section: Discussionsupporting

confidence: 51%

Quality of life questionnaires validate a remote approach to ophthalmic management of primary Sjögren’s syndrome

Greenan

Pilson

Gabhann-Dromgoole³

et al. 2022

Sci Rep

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Those with underlying autoimmune conditions were met with unparalleled challenges and were disproportionately affected by the COVID-19 pandemic. As such, we aimed to measure the impact of the pandemic on symptoms and the health and vision related quality of life (HR-QoL, VR-QoL) in patients with Primary Sjögren's Syndrome (pSS). Nineteen (55.9%) participants returned questionnaires for analysis, (17 female and 2 male, 61.6 years ± 9.9). There was no significant change in participants HR-QoL or VR-QoL, indicating that those with pSS remained resilient with regard to their physical and mental health throughout the pandemic. Furthermore, QoL was maintained despite 73.7% of participants having had outpatient appointments cancelled, delayed or rescheduled. Participants reported a lower QoL and feeling tenser in the COV19-QoL (3.3 ± 1.4 and 3.2 ± 1.3) representing feelings of apprehension and stress felt amongst the general population since the pandemic. Overall, and in spite of the concern caused by the COVID-19 pandemic for patients with autoimmune diseases, the health and well-being of patients with pSS remained stable. These findings strongly support the use of validated HR and VR-QoL questionnaires as an adjunct to the telemedicine consultation when assessing patients with pSS, offering an alternative to face-to-face consultations in post-pandemic era.

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Section: Discussionsupporting

confidence: 51%

Quality of life questionnaires validate a remote approach to ophthalmic management of primary Sjögren’s syndrome

Greenan

Pilson

Gabhann-Dromgoole³

et al. 2022

Sci Rep

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“…The pathogenesis of infectious disease by SARS-CoV-2 has been gradually unraveled. The effect or impact of SARS-CoV-2 infection on patients with patients with autoimmune diseases, including primary SS, has also been reported in the point of general emotional status, or various symptoms of SS [ 68 , 69 ]. Dry mouth due to SARS-CoV-2 infection is well known, and it has been suggested that the dry mouth of patients with SARS-CoV-2 infection may be induced by the neuroinvasive and neurotrophic properties of the virus, such as a chemokine monokine induced by IFN-γ (MIG) and IFN-γ-inducible protein 10 (IP10) [ 69 , 70 ].…”

Section: Future Perspectivesmentioning

confidence: 99%

Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome

Otsuka

Sato

Takemoto

et al. 2022

Viruses

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Sjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationship between virus infection and SS pathogenesis. In particular, infection with the Epstein-Barr (EB) virus among others is a potent factor associated with the onset or development of SS. Specifically, virus infection in the target organs of SS triggers or promotes autoreactive responses involving the process of autoantigen formation, antigen-presenting function, or T-cell response. Our review of recent research highlights the crucial roles of virus infection in the pathogenesis of SS and discusses the critical association between virus infection and the etiology of autoimmunity in SS.

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