The Impact of the Covid-19 Pandemic on Rhegmatogenous Retinal Detachment Treatment Patterns

Li, Jipeng; Zhao, Meng; She, Haicheng

doi:10.21203/rs.3.rs-526339/v2

Cited by 3 publications

(4 citation statements)

References 20 publications

(11 reference statements)

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“…The number of patients presenting with a macula-on retinal detachment was also lowest during the lockdown period in 2020 (39.2%) as compared to 2019 (50.0%) and 2021 (50.0%). These findings are in accordance with reports from other groups from many regions of the world including Europe, the USA, and Asia [21][22][23]. We assume that the slightly lower initial visual acuity reflects the macula status upon first presentation.…”

Section: Discussionsupporting

confidence: 92%

“…A similar situation was reported by Baudin and colleagues from France observing a decrease of 41.6% in the number of retinal detachment surgeries during the 8-week lockdown period in 2020 as compared to 2019. Similarly, a reduction in the number of cases as well as a prolonged time to surgery has been reported from Portugal and other regions of the world [20-22].…”

Section: Discussionmentioning

confidence: 67%

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Impact of COVID-19 before and after 2020 on Retinal Detachment Management in a Tertiary Eye Hospital in Germany

et al. 2022

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Introduction COVID-19 has had a tremendous impact on our everyday life. A growing body of evidence indicates that subsequent lockdowns and fear of exposure may have impacted patient care. We analyzed data on incidence and time to surgery in cases of rhegmatogenous retinal detachments (RRD) at three defined time points before, during and one year after the first lockdown period in Germany. Methods In this single center study, we identified all patients who were admitted and treated for a primary RRD in April and May 2020, the time of the first lockdown period in Germany and compared them with cases of the same time period in the years 2019 and 2021. The time from first occurrence of symptoms to surgery as well as visual outcome were analyzed. Results A total of 192 patients presented to our tertiary academic referral center with a RRD during the months of April and May in 2019 (72 patients), 2020 (62 patients) and 2021 (58 patients) and were included in this study. There were no significant differences with regard to gender and age. In 2019 the time interval between occurrence and presentation to our hospital amounted to a mean of 5.96 days and in 2021 to mean of 5.45 days. However, in 2020, the time between occurrence and presentation was significantly longer with a mean of 15.36 days. The number of patients presenting with a macula-on retinal detachment was also lowest in 2020 (39.2%) compared to 2019 (50.7%) and 2021 (50.0%). Furthermore, with 1.24 logMAR the mean BCVA upon initial presentation was lower in 2020 compared to 0.93 logMAR in 2019 and 1.06 logMAR in 2021. Six to twelve weeks following surgery, visual acuity had improved in 56.1% of patients in 2019 and 60.0% of patients in 2021 as compared to 59.0% in 2020 Conclusion We found significant differences in terms of elapsed time from first symptoms to surgical management for patients in 2020 in comparison to the same time period in 2019 and 2021. Less strict lockdown policies appear to impact patient behavior and patient care. Further measures, such as questionnaires, might help to address which measures may provide safer circumstances for patients to consult health care providers in the case of future strict lockdowns.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 67%

Impact of COVID-19 before and after 2020 on Retinal Detachment Management in a Tertiary Eye Hospital in Germany

et al. 2022

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“…postoperative visual outcomes of these patients were also significantly worse than before [4][5][6][7].…”

Section: Introductionmentioning

confidence: 81%

TSPAN4-positive migrasome derived from retinal pigmented epithelium cells contributes to the development of proliferative vitreoretinopathy

Yang

et al. 2022

J Nanobiotechnol

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Background Proliferative vitreoretinopathy (PVR) is a blind-causing disease initiated by the activation of retinal pigmented epithelium (RPE) primarily induced by TGF-β families. Migrasome is a recently discovered type of extracellular vesicle related to cell migration. Results Here, we used ex vivo, in vitro, and in vivo models, to investigate the characteristics and functions of migrasomes in RPE activation and PVR development. Results indicated that the migrasome marker tetraspanin-4 (TSPAN4) was abundantly expressed in human PVR-associated clinical samples. The ex vivo model PVR microenvironment is simulated by incubating brown Norway rat RPE eyecups with TGF-β1. Electron microscope images showed the formation of migrasome-like vesicles during the activation of RPE. Further studies indicated TGF-β1 increased the expression of TSPAN4 which results in migrasome production. Migrasomes can be internalized by RPE and increase the migration and proliferation ability of RPE. Moreover, TSPAN4-inhibited RPE cells are with reduced ability of initiating experimental PVR. Mechanically, TSPAN4 expression and migrasome production are induced through TGF-β1/Smad2/3 signaling pathway. Conclusion In conclusion, migrasomes can be produced by RPE under PVR microenvironment. Migrasomes play a pivotal role in RPE activation and PVR progression. Thus, targeting TSPAN4 or blocking migrasome formation might be a new therapeutic method against PVR.

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“…Jørstad et al reported a COVID-19 outbreak in an ophthalmology department, resulting in six COVID-19 cases and a two-week standstill in clinical activity [14]. Previous studies also revealed that the sudden outbreak of COVID-19 could lead to decreased ophthalmic outpatient volumes and poorer general care in ophthalmology [15][16][17][18][19][20][21][22][23]. Despite the clear data of recession in ophthalmic medical care, the exact distribution of diseases that were affected the most was never discussed.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 pandemic decreased the ophthalmic outpatient numbers and altered the diagnosis distribution in a community hospital in Taiwan: An observational study

et al. 2022

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The aim of this study was to determine the effect of Coronavirus disease 2019 (COVID-19) pandemic on ophthalmic outpatient numbers and ophthalmic diagnosis distribution in a community hospital (Taipei City Hospital Zhongxiao Branch) in Taiwan. The COVID-19 pandemic period in Taiwan was defined as May 1 to July 31, 2021. Demographic data, including age, gender, and top 10 diagnoses from ophthalmic outpatients during this period, were collected. A corresponding control group from the same time in 2020 was also collected. The distribution of different diagnoses was analyzed, and the data of 10 most prominent diagnoses with decreased percentage of case numbers during the COVID-19 pandemic period were obtained. The number of cases during the COVID-19 pandemic decreased by 46.9% compared to the control group. The top three most common diagnoses were dry eye syndrome, glaucoma, and macular diseases. The 10 most prominent diagnoses with decreased number of cases during the COVID-19 pandemic were cataract, refraction & accommodation, macular degeneration, conjunctivitis, retinal detachment, vitreous body disorders, ophthalmic complications of diabetes mellitus, glaucoma, dry eye, and retinal vein occlusion. Identifying and treating these patients as scheduled may yield the highest cost-benefit effect in preventing visual loss during the COVID-19 pandemic.

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The Impact of the Covid-19 Pandemic on Rhegmatogenous Retinal Detachment Treatment Patterns

Cited by 3 publications

References 20 publications

Impact of COVID-19 before and after 2020 on Retinal Detachment Management in a Tertiary Eye Hospital in Germany

Impact of COVID-19 before and after 2020 on Retinal Detachment Management in a Tertiary Eye Hospital in Germany

TSPAN4-positive migrasome derived from retinal pigmented epithelium cells contributes to the development of proliferative vitreoretinopathy

COVID-19 pandemic decreased the ophthalmic outpatient numbers and altered the diagnosis distribution in a community hospital in Taiwan: An observational study

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