The Impact of the COVID-19 Pandemic on the Cognition of People with Dementia

Tondo, Giacomo; Sarasso, Barbara; Serra, Paola; Tesser, Fabiana; Comi, Cristoforo

doi:10.3390/ijerph18084285

Cited by 31 publications

(28 citation statements)

References 61 publications

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“…Furthermore, the impact of the COVID-19 pandemic and its associated social restrictions has been observed in the progression of cognitive impairment in people with dementia and in the exacerbation of neuropsychiatric symptoms in people with chronic neurological diseases [155]. One study examining the effects of quarantine in patients with Alzheimer's disease (AD), frontotemporal dementia (FTD), vascular dementia (VD) and dementia with Lewy bodies (DLB) found that approximately 60% of patients experienced changes in behavioural and psychological symptoms (BPSD) after one month of isolation, including worsening of previous symptoms (51.9%) or emergence of new symptoms (26%).…”

Section: The Covid-19 Pandemic As a Psychological Stress Factormentioning

confidence: 99%

Depressive and Neurocognitive Disorders in the Context of the Inflammatory Background of COVID-19

Dąbrowska

Galińska-Skok

Waszkiewicz

2021

Life

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The dysfunctional effects of the coronavirus disease 2019 (COVID-19) infection on the nervous system are established. The manifestation of neuropsychiatric symptoms during and after infection is influenced by the neuroinvasive and neurotrophic properties of SARS-CoV-2 as well as strong inflammation characterised by a specific “cytokine storm”. Research suggests that a strong immune response to a SARS-CoV-2 infection and psychological stressors related to the pandemic may cause chronic inflammatory processes in the body with elevated levels of inflammatory markers contributing to the intensification of neurodegenerative processes. It is suggested that neuroinflammation and associated central nervous system changes may significantly contribute to the etiopathogenesis of depressive disorders. In addition, symptoms after a COVID-19 infection may persist for up to several weeks after an acute infection as a post-COVID-19 syndrome. Moreover, previous knowledge indicates that among SSRI (selective serotonin reuptake inhibitor) group antidepressants, fluoxetine is a promising drug against COVID-19. In conclusion, further research, observation and broadening of the knowledge of the pathomechanism of a SARS-CoV-2 infection and the impact on potential complications are necessary. It is essential to continue research in order to assess the long-term neuropsychiatric effects in COVID-19 patients and to find new therapeutic strategies.

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Section: The Covid-19 Pandemic As a Psychological Stress Factormentioning

confidence: 99%

Depressive and Neurocognitive Disorders in the Context of the Inflammatory Background of COVID-19

Dąbrowska

Galińska-Skok

Waszkiewicz

2021

Life

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“…Therefore, all societies affected by the SARS-CoV-2 infection have gradually declared social distancing and home-confinement to prevent the spread of the new infection. According to Tondo et al [1], the COVID-19 pandemic generates substantial changes in routine activities, restrictions of movement and has a considerable impact on people's psychological and cognitive levels. Furthermore, it 2 of 26 creates challenges for the healthcare system.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, it 2 of 26 creates challenges for the healthcare system. The main problems in dementia during this pandemic period are related to an increase of sufferers of cognitive impairment [1].…”

Section: Introductionmentioning

confidence: 99%

New Recovery Strategies in Motor and Cognitive Functions, before, during and after Home-Confinement COVID-19, for Healthy Adults and Patients with Neurodegenerative Diseases: Review

Bacanoiu

Danoiu

Marin

et al. 2022

JCM

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Distancing and confinement at home during the Coronavirus Disease 2019 (COVID-19) outbreak has led to worsening of motor and cognitive functions, both for healthy adults and for patients with neurodegenerative diseases. The decrease in physical activity, the cessation of the intervention of the recovery and the social distance imposed by the lockdown, has had a negative impact on the physical and mental health, quality of life, daily activities, as well as on the behavioral attitudes of the diet. The purpose of this paper was to evaluate the impact of decreasing physical activity and the affected emotional status in healthy adults and patients with neurodegenerative diseases in conditions imposed by the stay at home mandate of COVID-19, along with new interventions, such as telemedicine and telerehabilitation. These interventions include online surveys carried out in multi-languages, semi-structured interviews, intervention smartphones and interventions through online platforms, for instance: Google, WhatsApp, Twitter, ResearchGate, Facebook and LinkedIn. For this study, we selected original papers that were intensively processed using characteristics co-related with physical activity, mental wellbeing, sleep quality, good eating behavior and healthy lifestyle. By searching the last two years of literature, our review presents and demonstrates the benefit of online technological interventions in lockdown, which promote physical exercise patterns and rehabilitation techniques, for healthy adults and patients with neurodegenerative diseases, and the need to develop new strategic directions and governmental measures, designed procedures and health services, which are expected to improve the quality of life, the progress of physical and cognitive functions, mental health and wellbeing for all.

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“…Cumulative research results clearly indicate the beneficial effects of physical activity (PA) on brain health, and some reports have suggested that physical inactivity in older adults caused by COVID-19 pandemic-related lockdowns have had a negative impact on brain health ( Fiorenzato et al, 2021 ; Ismail et al, 2021 ; Tondo et al, 2021 ; Znazen et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain

Umegaki

Sakurai

Arai

2021

Front. Aging Neurosci.

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A growing body of evidence clearly indicates the beneficial effects of physical activity (PA) on cognition. The importance of PA is now being reevaluated due to the increase in sedentary behavior in older adults during the COVID-19 pandemic. Although many studies in humans have revealed that PA helps to preserve brain health, the underlying mechanisms have not yet been fully elucidated. In this review, which mainly focuses on studies in humans, we comprehensively summarize the mechanisms underlying the beneficial effects of PA or exercise on brain health, particularly cognition. The most intensively studied mechanisms of the beneficial effects of PA involve an increase in brain-derived neurotrophic factor (BDNF) and preservation of brain volume, especially that of the hippocampus. Nonetheless, the mutual associations between these two factors remain unclear. For example, although BDNF presumably affects brain volume by inhibiting neuronal death and/or increasing neurogenesis, human data on this issue are scarce. It also remains to be determined whether PA modulates amyloid and tau metabolism. However, recent advances in blood-based biomarkers are expected to help elucidate the beneficial effects of PA on the brain. Clinical data suggest that PA functionally modulates cognition independently of neurodegeneration, and the mechanisms involved include modulation of functional connectivity, neuronal compensation, neuronal resource allocation, and neuronal efficiency. However, these mechanisms are as yet not fully understood. A clear understanding of the mechanisms involved could help motivate inactive persons to change their behavior. More accumulation of evidence in this field is awaited.

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The Impact of the COVID-19 Pandemic on the Cognition of People with Dementia

Cited by 31 publications

References 61 publications

Depressive and Neurocognitive Disorders in the Context of the Inflammatory Background of COVID-19

Depressive and Neurocognitive Disorders in the Context of the Inflammatory Background of COVID-19

New Recovery Strategies in Motor and Cognitive Functions, before, during and after Home-Confinement COVID-19, for Healthy Adults and Patients with Neurodegenerative Diseases: Review

Active Life for Brain Health: A Narrative Review of the Mechanism Underlying the Protective Effects of Physical Activity on the Brain

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