The impact of the catechol‐<scp><i>O</i></scp>‐methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion

Miller, Rosalind J.; Jackson, Kim G.; Dadd, Tony; Mayes, Andrew E.; Brown, Angela L.; Lovegrove, Julie A.; Minihane, Anne‐Marie

doi:10.1002/mnfr.201100726

Cited by 33 publications

(25 citation statements)

References 41 publications

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“…In a cross-sectional analysis of a subset of the Shanghai Cohort, the AA genotype had significantly lower urinary total polyphenols and concentrations of 3 of the 5 specific tea polyphenol metabolites [(−)-epigallocatechin, 4′-methylepigallocatechin and 5-(3′,4′,5′-trihydroxyphenyl)-γ-valerolactone] relative to the GG and GA groups with a trend for genotype-associated differences in epicatechin and 5-(3′,4′-dihydroxyphenyl)-γ-valerolactone (45). Consistent with these findings, in participants who were prospectively recruited according to genotype, urinary methylated epigallocatechin concentrations were significantly higher in the GG COMT group than in AA homozygotes after acute consumption of green-tea extract (68). In the Minnesota Green Tea Trial, overweight and obese postmenopausal women underwent a 12-mo intervention that examined the impact of green-tea extract on adiposity and measures of cardiometabolic health (69).…”

Section: Etiology Of the Heterogeneity In Flavonoid Admesupporting

confidence: 54%

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Cassidy

Minihane

2017

The American Journal of Clinical Nutrition

390

287

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At a population level, there is growing evidence of the beneficial effects of dietary flavonoids on health. However, there is extensive heterogeneity in the response to increased intake, which is likely mediated via wide interindividual variability in flavonoid absorption and metabolism. Flavonoids are extensively metabolized by phase I and phase II metabolism (which occur predominantly in the gastrointestinal tract and liver) and colonic microbial metabolism. A number of factors, including age, sex, and genotype, may affect these metabolic processes. In addition, food composition and flavonoid source are likely to affect bioavailability, and emerging data suggest a critical role for the microbiome. This review will focus on the current knowledge for the main subclasses of flavonoids, including anthocyanins, flavonols, flavan-3-ols, and flavanones, for which there is growing evidence from prospective studies of beneficial effects on health. The identification of key factors that govern metabolism and an understanding of how the differential capacity to metabolize these bioactive compounds affect health outcomes will help establish how to optimize intakes of flavonoids for health benefits and in specific subgroups. We identify research areas that need to be addressed to further understand important determinants of flavonoid bioavailability and metabolism and to advance the knowledge base that is required to move toward the development of dietary guidelines and recommendations for flavonoids and flavonoid-rich foods.

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Section: Etiology Of the Heterogeneity In Flavonoid Admesupporting

confidence: 54%

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Cassidy

Minihane

2017

The American Journal of Clinical Nutrition

390

287

View full text Add to dashboard Cite

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“…In this regard, an increasing number of genetic variants has been identified and related to obesity and diet-interaction and, the studied population has been segregated into groups of responders and non-responders in association with the specific genetic variations [190]. A number of studies have now also looked at the role of specific host genetic variants in response to the consumption of polyphenols or polyphenol-containing products, including genetic polymorphisms involved in: (i) the metabolism and transport of polyphenols such as Catechol- O -methyl transferase [191] or phase II enzymes UGT1A1 [192] and (ii) the cardiometabolic responses such as the lipid and blood pressure variation associated with the apolipoprotein e genotype in response to quercetin in overweight people [193] or the interaction between the IL-6 -174 G/C polymorphism and the reduction of body fat following the intake of a polyphenol-rich apple juice [194]. More genes and polymorphisms involved in the response to polyphenols need to be identified and more RCTs need to be performed reporting and associating the presence of those relevant genetic polymorphisms, as well the microbiota composition and microbiota-derived metabolic phenotype with the differences in the response of the individuals to the consumption plant food bioactive compounds.…”

Section: Discussionmentioning

confidence: 99%

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Garcı́a-Conesa

Chambers

Combet

et al. 2018

IJMS

116

107

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Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin- and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose were most significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.

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“…EGCG has a low absorption rate (probably <5%) and an average Tmax of 2 hours after oral administration (112, 113), due to its instability in the air and inactivation in the gastrointestinal tract and liver (114). Thus, EGCG also has poor bioavailability, similar to curcumin.…”

Section: Phytochemicals With Nrf2-are Activating Abilitymentioning

confidence: 99%

Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases

Sun

Yang

Leak

et al. 2017

CNSNDDT

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Central nervous system diseases are major health issues and are often associated with disability or death. Most central nervous system disorders are characterized by high levels of oxidative stress. Nuclear factor erythroid 2 related factor (Nrf2) is known for its ability to regulate the expression of a series of enzymes with antioxidative, prosurvival, and detoxification effects. Under basal conditions, Nrf2 forms a complex with Kelch-like ECH associated protein 1, leading to Nrf2 inactivation via ubiquitination and degradation. However, following exposure of Keap1 to oxidative stress, Nrf2 is released from Keap1, activated, and translocated into the nucleus. Upon nuclear entry, Nrf2 binds to antioxidant response elements (ARE), thereby inducing the expression of genes such as glutathione s-transferase, heme oxygenase 1, and NADPH quinine oxidoreductase 1. Many dietary phytochemicals have been reported to activate the protective Nrf2/ARE pathway. Here, we review the preventive and protective effects of dietary Nrf2 activators against CNS diseases, including stroke, traumatic brain injury, Alzheimer’s disease, and Parkinson’s disease.

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The impact of the catechol‐O‐methyltransferase genotype on vascular function and blood pressure after acute green tea ingestion

Abstract: Differences in small vessel tone according to COMT genotype were evident after acute green tea extract.

Cited by 33 publications

References 41 publications

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

The role of metabolism (and the microbiome) in defining the clinical efficacy of dietary flavonoids

Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases

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