The impact of the advanced lung cancer inflammation index on the outcomes of patients with metastatic colorectal cancer who receive chemotherapy

Horino, Taichi; Tokunaga, Ryuma; Miyamoto, Yuji; Hiyoshi, Yukiharu; Akiyama, Takahiko; Daitoku, Nobuya; Sakamoto, Yuki; Yoshida, Naoya; Baba, Hideo

doi:10.1007/s10147-023-02293-2

Cited by 3 publications

(1 citation statement)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Colorectal cancer is the third most common malignancy worldwide, and liver metastases develop in 30-50% of patients during their disease course [1][2][3]. Although hepatectomy remains the curative treatment of choice for colorectal liver metastasis (CRLM), 50-70% of patients with CRLM develop disease recurrence within the rst 2 years after hepatectomy [4].…”

Section: Introductionmentioning

confidence: 99%

Patient vulnerability is associated with poor prognosis following upfront hepatectomy for colorectal liver metastasis

Mima,

Hayashi,

Adachi

et al. 2023

Int J Clin Oncol

Self Cite

View full text Add to dashboard Cite

Background:With the rapid aging of populations worldwide, the number of vulnerable patients with liver metastasis from colorectal cancer has increased. This study aimed to examine the association between vulnerability and clinical outcomes in patients with colorectal liver metastasis (CRLM). Methods:Consecutive 101 patients undergoing upfront hepatectomy for CRLM between 2004 and 2020 were included. The preoperative vulnerability was assessed using the Clinical Frailty Scale (CFS) score ranging from one (very t) to nine (terminally ill), and frailty was de ned as a CFS score of ≥ 4. A multivariable Cox proportional hazard regression model was utilized to investigate the association of frailty with disease-free survival (DFS) and overall survival (OS). Results:Of the 101 patients, 12 (12%) had frailty. Associations between frailty and surgical outcomes, namely, the incidence of 90-day mortality and postoperative complications, were not statistically signi cant (P > 0.05). In the multivariable analyses, after adjusting for clinical risk scores calculated using six factors (timing of liver metastasis, primary tumor lymph node status, number of liver tumors, the largest diameter of liver tumor, extrahepatic metastatic disease, and carbohydrate antigen 19 − 9 level) to predict recurrence following hepatectomy for CRLM, preoperative frailty was found to be an independent risk factor for DFS (hazard ratio [HR]: 2.64, 95% con dence interval [

show abstract

Section: Introductionmentioning

confidence: 99%

Patient vulnerability is associated with poor prognosis following upfront hepatectomy for colorectal liver metastasis

Mima,

Hayashi,

Adachi

et al. 2023

Int J Clin Oncol

Self Cite

View full text Add to dashboard Cite

show abstract

Patient vulnerability is associated with poor prognosis following upfront hepatectomy for colorectal liver metastasis

Mima

Hayashi

Adachi

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Background: With the rapid aging of populations worldwide, the number of vulnerable patients with liver metastasis from colorectal cancer has increased. This study aimed to examine the association between vulnerability and clinical outcomes in patients with colorectal liver metastasis (CRLM). Methods: Consecutive 101 patients undergoing upfront hepatectomy for CRLM between 2004 and 2020 were included. The preoperative vulnerability was assessed using the Clinical Frailty Scale (CFS) score ranging from one (very fit) to nine (terminally ill), and frailty was defined as a CFS score of ≥ 4. A multivariable Cox proportional hazard regression model was utilized to investigate the association of frailty with disease-free survival (DFS) and overall survival (OS). Results: Of the 101 patients, 12 (12%) had frailty. Associations between frailty and surgical outcomes, namely, the incidence of 90-day mortality and postoperative complications, were not statistically significant (P > 0.05). In the multivariable analyses, after adjusting for clinical risk scores calculated using six factors (timing of liver metastasis, primary tumor lymph node status, number of liver tumors, the largest diameter of liver tumor, extrahepatic metastatic disease, and carbohydrate antigen 19 − 9 level) to predict recurrence following hepatectomy for CRLM, preoperative frailty was found to be an independent risk factor for DFS (hazard ratio [HR]: 2.64, 95% confidence interval [CI]: 1.19–5.25, P = 0.019) and OS (HR: 4.17, 95%CI: 1.43–10.89, P = 0.011). Conclusion: Preoperative frailty was associated with worse DFS and OS after upfront hepatectomy for CRLM. Assessment and improvement of patient vulnerability may provide a favorable prognosis for patients with CRLM.

show abstract

Advanced Lung Cancer Inflammation Index: A Novel Comprehensive Biomarker of Host Status for Patients with Metastatic Colorectal Cancer

Horino,

Tokunaga,

Miyamoto

et al. 2024

J Anus Rectum Colon

View full text Add to dashboard Cite

Numerous biomarkers that reflect host status have been identified for patients with metastatic colorectal cancer (mCRC). However, there has been a paucity of biomarker studies that comprehensively indicate body composition, nutritional assessment, and systemic inflammation status. The advanced lung cancer inflammation index (ALI), initially introduced as a screening tool for patients with non-small-cell lung cancer in 2013, emerges as a holistic marker encompassing all body composition, nutritional status, and systemic inflammation status. The index is calculated by the simple formula: body mass index × albumin value / neutrophil-to-lymphocyte ratio. Given its accessibility in routine clinical practice, the ALI has exhibited promising clinical utility in prognosticating outcomes for patients with multiple types of cancer. In this review, we focus on the significance of host status and the clinical applicability of the ALI in the treatment and management of patients with malignancies, including mCRC. We also suggest its potential in guiding the formulation of treatment strategies against mCRC and outline future perspectives.

show abstract

The impact of the advanced lung cancer inflammation index on the outcomes of patients with metastatic colorectal cancer who receive chemotherapy

Cited by 3 publications

References 35 publications

Patient vulnerability is associated with poor prognosis following upfront hepatectomy for colorectal liver metastasis

Patient vulnerability is associated with poor prognosis following upfront hepatectomy for colorectal liver metastasis

Patient vulnerability is associated with poor prognosis following upfront hepatectomy for colorectal liver metastasis

Advanced Lung Cancer Inflammation Index: A Novel Comprehensive Biomarker of Host Status for Patients with Metastatic Colorectal Cancer

Contact Info

Product

Resources

About