The impact of survivorship bias in glioblastoma research

Pasqualetti, Francesco; Barberis, Alessandro; Zanotti, Sofia; Montemurro, Nicola; Salvo, Gian Luca De; Soffietti, Riccardo; Mazzanti, Chiara Maria; Ius, Tamara; Caffo, Maria; Paiar, Fabiola; Bocci, Guido; Lombardi, Giuseppe; Harris, Adrian L.; Buffa, Francesca M.

doi:10.1016/j.critrevonc.2023.104065

Cited by 13 publications

(9 citation statements)

References 44 publications

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“…However, in patients with extensive coronary calcifications, no statistically significant association was found between total CACs and the left carotid bifurcation score or the proximal internal branch score. It should also be pointed out that this analysis was performed in patients symptomatic for cardiovascular disease, therefore introducing a selection bias [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, Barz et al evaluated the impact of the age-adjusted Charlson comorbidity index (ACCI) in patients diagnosed with GBM, finding no association between ACCI and prognosis [ 10 ]. However, in that study, the patient sample was heterogeneous and not all GBMs had been administered in the same postoperative treatment, with only 27 out of 123 patients having received postoperative radiotherapy [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

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Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?

Pasqualetti,

Gabelloni,

Faggioni

et al. 2024

JCM

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Purpose: Clinical evidence suggests an association between comorbidities and outcome in patients with glioblastoma (GBM). We hypothesised that the internal carotid artery (ICA) calcium score could represent a promising prognostic biomarker in a competing risk analysis in patients diagnosed with GBM. Methods: We validated the use of the ICA calcium score as a surrogate marker of the coronary calcium score in 32 patients with lung cancer. Subsequently, we assessed the impact of the ICA calcium score on overall survival in GBM patients treated with radio-chemotherapy. Results: We analysed 50 GBM patients. At the univariate analysis, methyl-guanine-methyltransferase gene (MGMT) promoter methylation (p = 0.048), gross total tumour resection (p = 0.017), and calcium score (p = 0.011) were significant prognostic predictors in patients with GBM. These three variables also maintained statistical significance in the multivariate analysis. Conclusions: the ICA calcium score could be a promising prognostic biomarker in GBM patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?

Pasqualetti,

Gabelloni,

Faggioni

et al. 2024

JCM

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“…As a result of the gaps observed between knowledge, attitude, and practices, more effective methods and considerable effort should be invested to better analyze the reasons for what motivates behavior change ( 22 ). The PMT framework for systematic behavior involved three phases: (1) assessing the risks; (2) benefiting from take protective measures; (3) making a decision.…”

Section: Discussionmentioning

confidence: 99%

Protection motivation theory in predicting intentional behaviors regards schistosomiasis: a WeChat-based qualitative study

Wang,

Li,

Zhang

et al. 2024

Front. Public Health

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BackgroundModifications of behavior can help reduce the risk of transmission by disrupting the parasite life cycle. Behavior intension is a necessary intermediate step in behavior change. This study aimed to explore protection motivation theory (PMT) in predicting likelihood of engagement in protective behavior against infection with Schistosoma.MethodsIn China, a questionnaire for data collection was sent to users who followed the WeChat public account from June 2 to 6, 2023. Factors affecting intentional behavior of participants were analyzed using stepwise regression analysis and structural equation modeling.ResultsA total of 2,243 valid questionnaires were collected, with a mean age of 30 ± 8.4 years. Approximately 1,395 (62.2%) participants reported that they had been exposed to wild waters in daily work and life. About 51.0 and 50.7% of respondents reported never having been exposed to wild water in the last 3 and 6 months, respectively. Results indicated that prior knowledge of schistosomiasis was associated with the 7 PMT subconstructs, which then influenced future preventative behaviors.ConclusionBehavior intentionis a complicated and indispensable part of behavior change that is influenced by professional knowledge, socio-economic status, and personal characteristics. The effective dissemination of knowledge regards schistosomiasis should be strengthened to emphasize the effectiveness of protective measures against infection and severe disease.

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“…Sippl and colleagues [ 58 ] showed a significant overexpression of miR-181d in the tumor tissue and plasma of glioblastoma patients compared with healthy individuals. Even if the majority of prognostic and predictive GB biomarkers are currently developed using tumor samples obtained through surgical interventions [ 59 , 60 ], the AUC values indicate that the two groups may be distinguished by the expression analysis of miR-181d. In addition, the authors demonstrated that The Cancer Genome Atlas analysis revealed 8 potential protein targets to be regulated by miR-181d.…”

Section: Cell-free Mirnas As Diagnostic and Prognostic Biomarkersmentioning

confidence: 99%

Cell-Free miRNAs as Non-Invasive Biomarkers in Brain Tumors

Beylerli,

Encarnacion Ramirez,

Shumadalova

et al. 2023

Diagnostics

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Diagnosing brain tumors, especially malignant variants, such as glioblastoma, medulloblastoma, or brain metastasis, presents a considerable obstacle, while current treatment methods often yield unsatisfactory results. The monitoring of individuals with brain neoplasms becomes burdensome due to the intricate tumor nature and associated risks of tissue biopsies, compounded by the restricted accuracy and sensitivity of presently available non-invasive diagnostic techniques. The uncertainties surrounding diagnosis and the tumor’s reaction to treatment can lead to delays in critical determinations that profoundly influence the prognosis of the disease. Consequently, there exists a pressing necessity to formulate and validate dependable, minimally invasive biomarkers that can effectively diagnose and predict brain tumors. Cell-free microRNAs (miRNAs), which remain stable and detectable in human bodily fluids, such as blood and cerebrospinal fluid (CSF), have emerged as potential indicators for a range of ailments, brain tumors included. Numerous investigations have showcased the viability of profiling cell-free miRNA expression in both CSF and blood samples obtained from patients with brain tumors. Distinct miRNAs demonstrate varying expression patterns within CSF and blood. While cell-free microRNAs in the blood exhibit potential in diagnosing, prognosticating, and monitoring treatment across diverse tumor types, they fall short in effectively diagnosing brain tumors. Conversely, the cell-free miRNA profile within CSF demonstrates high potential in delivering precise and specific evaluations of brain tumors.

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The impact of survivorship bias in glioblastoma research

Cited by 13 publications

References 44 publications

Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?

Glioblastoma and Internal Carotid Artery Calcium Score: A Possible Novel Prognostic Partnership?

Protection motivation theory in predicting intentional behaviors regards schistosomiasis: a WeChat-based qualitative study

Cell-Free miRNAs as Non-Invasive Biomarkers in Brain Tumors

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