The Impact of Surgical Treatment with Adjuvant Chemotherapy for Ovarian Cancer on Disorders in the Urinary System and Quality of Life in Women

Opławski, Marcin; Grabarek, Beniamin Oskar; Średnicka, Agata; Czarniecka, Justyna; Panfil, Agata; Kojs, Zbigniew; Boroń, Dariusz

doi:10.3390/jcm11051300

Cited by 5 publications

(7 citation statements)

References 46 publications

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“…Fourthly, this is one of very few studies from Poland regarding sexual function – the latest was recently published by Opławski et al . showing (by using satisfaction with life scale and sexual satisfaction scale) a deterioration of sexual function in ovarian cancer patients that did not markedly improve over time after surgery or surgery plus chemotherapy [ 14 ]. That paper, however, did not assess couple’s sexuality.…”

Section: Discussionmentioning

confidence: 99%

Couples’ sexual health after gynaecological cancer diagnosis – an unexplored area for further research

Nowosielski¹,

Pałka²

2023

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Introduction The aim of the study was to assess the sexual inhibitory tone, body image, self-concept, and sexual performance in couples after gynaecological cancer treatment, and to identify areas for further prospective studies. Material and methods Thirty gynaecological cancer survivors with a heterosexual partner were assessed during a semi-structural sexual interview. Sexual excitation/sexual inhibition scales were used to evaluate proneness to sexual stimuli, whereas a body exposure during sexual activity questionnaire was used to assess body avoidance during sex. Self-concept in cancer survivors was evaluated by a sexual self-scheme scale. The differences in sexual needs, satisfaction, and sexual activity were comped between women and their partners. Results In survivors and their partners the sexual inhibitory tone was higher than the excitatory tone – 3.91 and 2.45 vs. 2.97 and 2.31, respectively. Most women were schematic-positive and co-schematic – 46.7% and 40.0%, respectively. The decrease in importance of sex was higher in women compared to their partners (D change –0.88 and –0.22, respectively). The frequency of satisfying sex decreased after treatment in women but increased in their partners – D change: –1.04 and +2.94, respectively. Satisfaction with sexual life and quality of relationship improved or did not change after cancer diagnosis in women. None of the sexual response elements were changed by the cancer diagnosis in partners. Conclusions In cancer survivors with a sexual partner, both people should be carefully counselled because there are some important differences in perception of sexual needs within the couple. Avoiding body exposure during sex and differences in proneness to sexual stimuli should be explored in further studies.

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Section: Discussionmentioning

confidence: 99%

Couples’ sexual health after gynaecological cancer diagnosis – an unexplored area for further research

Nowosielski¹,

Pałka²

2023

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“…In this cohort, we found a significant rate (27%) of acute urinary dysfunction among patients with cancer undergoing acute inpatient rehabilitation. Previous studies on urinary dysfunction in patients with cancer reported a variety of urinary dysfunction types affecting the quality of life [9][10][11][12]. These studies concentrated on patients with specific cancer types such as prostate, colorectal, endometrial, and ovarian cancer [9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies on urinary dysfunction in patients with cancer reported a variety of urinary dysfunction types affecting the quality of life [9][10][11][12]. These studies concentrated on patients with specific cancer types such as prostate, colorectal, endometrial, and ovarian cancer [9][10][11][12]. Other studies have described urinary dysfunction primarily in patients undergoing inpatient rehabilitation for strokes [19], brain disorders [20][21], spinal cord disorders [22][23][24], and other neurological conditions.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with cancer can develop urinary dysfunction due to their disease [7] or its treatments, such as chemotherapy, immunotherapy, pelvic radiation, or surgery [7,8]. Previous studies on urinary dysfunction primarily concentrated on a few specific cancer types and a variety of urinary dysfunction types [9][10][11][12]. Patients with cancer undergoing acute inpatient rehabilitation after hospitalization, however, have a wide variety of heterogeneous cancer types.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Dysfunction: Frequency, Risk factors, and Interventions in patients with Cancer during Acute Inpatient Rehabilitation

Tennison¹,

Pally²,

Fellman³

et al. 2023

J. Cancer

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Introduction: Urinary dysfunction has a strong impact clinically, socially, and economically. Although the development of acute urinary dysfunction in hospitalized patients with cancer is common in clinical practice, its occurrence and management strategies are scant in the literature. It has been reported as one of the more common medical complications in patients with cancer undergoing acute inpatient rehabilitation. This study assessed the frequency of and risk factors for acute urinary dysfunction among these patients and identified the interventions used for management. Methods: This is a retrospective study of consecutive patients admitted to a National Cancer Institute Comprehensive Cancer Center's acute inpatient rehabilitation service from 9/1/2020 through 3/15/2021. We excluded patients that were readmissions during the study time frame. We collected patients' demographic, clinical, and functional data. We defined acute urinary dysfunction as the development of any new urinary symptom(s) or diagnosis, which involved additional work-up and/or management after admission to the acute inpatient rehabilitation service. Results: Of the 176 total patients included in this study, 47 (27%; 95% confidence interval [CI], 20-34) patients had acute urinary dysfunction. The most frequent diagnoses were urinary tract infection (32%) and neurogenic bladder (26%). The most common tests were urine cultures (32%) and urinalyses (30%). The most commonly prescribed medications were antibiotics (32%) and alpha-1 blockers (15%). Other most frequent interventions included timed voiding (34%) and intermittent catheterization with bladder scans (28%). Acute urinary dysfunction was associated with an increased length of stay on the inpatient rehabilitation service (odds ratio [OR], 1.13; 95% CI, 1.06-1.20; P<.001), surgery during the index admission (OR, 2.50; 95% CI, 1.21-5.16; P=.014), and fecal incontinence (OR, 6.41; 95% CI, P=.004). Conclusion: Acute urinary dysfunction was noted to be a substantial problem in this cohort. This is an overlooked dimension of inpatient cancer rehabilitation that deserves more attention. Patients at risk for acute urinary dysfunction may benefit from close monitoring for medical management and rehabilitation interventions to maximize functional independence with bladder care. More research regarding acute urinary dysfunction types and management approaches in post-acute care settings for patients with cancer is justified.

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“…Patients are classified according to those who have achieved a complete response (CR), a partial response (PR), a stable disease (SD) state, and progression (PR) [ 10 , 11 , 12 , 13 ]. In a previous study, we conducted a clinical and molecular characterization of the same ovarian cancer patients in the context of treatment efficacy and chemotherapy resistance [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Detection and Genotyping of Human Papillomavirus (HPV16/18), Epstein–Barr Virus (EBV), and Human Cytomegalovirus (HCMV) in Endometrial Endometroid and Ovarian Cancers

Grabarek¹,

Ossowski²,

Czarniecka³

et al. 2023

Pathogens

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The purpose of this study was to evaluate the relationship between human papillomavirus (HPV16/18), Epstein–Barr virus (EBV), and human cytomegalovirus (HCMV) infections and the occurrence of ovarian cancer in 48 women, of whom 36 underwent surgery and chemotherapy (group A), 12 in whom surgery was sufficient (group B), and 60 with endometroid endometrial cancer stage G1-G3 (group C), compared to patients in whom the uterus and its appendages were removed for nononcological reasons (control group). The detection of HPV, EBV, and HCMV in tumor tissue and normal tissue was performed using the real-time polymerase chain reaction (RT-PCR) technique. A statistically significantly higher risk of endometrial cancer was noted in patients infected only with HCMV (OR > 1; p < 0.05). In contrast, a significantly higher risk of ovarian cancer in group A was associated with HPV16, HPV18, and EBV (OR > 1; p < 0.05); a significantly higher risk of ovarian cancer in group B was associated with HPV18 and HMCV (OR > 1; p < 0.05). The obtained results suggest that HCMV infection is associated with the development of a stage of ovarian cancer when treatment can be completed with surgery alone. Meanwhile, EBV appears to be responsible for the development of ovarian cancer in more advanced stages.

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The Impact of Surgical Treatment with Adjuvant Chemotherapy for Ovarian Cancer on Disorders in the Urinary System and Quality of Life in Women

Cited by 5 publications

References 46 publications

Couples’ sexual health after gynaecological cancer diagnosis – an unexplored area for further research

Couples’ sexual health after gynaecological cancer diagnosis – an unexplored area for further research

Urinary Dysfunction: Frequency, Risk factors, and Interventions in patients with Cancer during Acute Inpatient Rehabilitation

Detection and Genotyping of Human Papillomavirus (HPV16/18), Epstein–Barr Virus (EBV), and Human Cytomegalovirus (HCMV) in Endometrial Endometroid and Ovarian Cancers

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