The impact of stress systems and lifestyle on dyslipidemia and obesity in anxiety and depression

Dortland, Arianne K. B. van Reedt; Vreeburg, Sophie A.; Giltay, Erik J.; Licht, Carmilla M.M.; Vogelzangs, Nicole; Veen, Tineke van; Geus, Eco J. C. de; Penninx, Brenda W. J. H.; Zitman, Frans G.

doi:10.1016/j.psyneuen.2012.05.017

Cited by 102 publications

(50 citation statements)

References 66 publications

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“…Studies of patients with anxiety disorders reported a correlation between dyslipidemia and anxiety disorders [25,43]. Glucocorticoids play an important role in lipid metabolism.…”

Section: Oxygen Consumptionmentioning

confidence: 99%

Endocrine and metabolic function in male Carioca High-conditioned Freezing rats

Mousovich-Neto

Lourenço

Landeira-Fernández

et al. 2015

Physiology & Behavior

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“…Studies of patients with anxiety disorders reported a correlation between dyslipidemia and anxiety disorders [25,43]. Glucocorticoids play an important role in lipid metabolism.…”

Section: Oxygen Consumptionmentioning

confidence: 99%

Endocrine and metabolic function in male Carioca High-conditioned Freezing rats

Mousovich-Neto

Lourenço

Landeira-Fernández

et al. 2015

Physiology & Behavior

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“…The biological mechanisms behind depression include the autonomous nervous system and monoamine neurotransmission dysfunction, cytokinemediated inflammatory reactions [5][6][7], and overactivity of the hypothalamic-pituitary-adrenal (HPA) axis [8][9][10]. Psychological factors may also play a significant role, as the metabolic syndrome is associated with a passive life attitude and negative self-image, both of which may contribute to the development of depression [11,12].…”

Section: Introductionmentioning

confidence: 99%

Depressive symptoms are associated with poor outcome for lumbar spine surgery

Järvimäki

Kautiainen

Haanpää

et al. 2016

Scandinavian Journal of Pain

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AbstractBackground and aimsThe symptoms of pain and depression often present concomitantly, but little is known as to how the different subtypes of depression affect surgical outcome. The aim of this study was to determine whether there is a difference in outcome after lumbar spine surgery between non-depressed patients and patients with different subtypes of depressive symptoms: non-melancholic (NmDS) and melancholic depression (MDS).MethodsThis was a cross-sectional postal survey. A self-made questionnaire, the Beck Depression Inventory (BDI) and the Oswestery Low Back Disability Questionnaire (ODI) were sent to patients who had undergone lumbar spine surgery in the Oulu University Hospital between June, 2005 and May, 2008. BDI ≤ 10 were further classified into NmDS or MDS.ResultsA total of 537 patients (66%) completed the survey. Of these, 361 (67%) underwent disc surgery, 85 (16%) stabilizing surgery and 91 (17%) decompression. Participants were divided into three groups: BDI< 10 N=324 (60%), NmDS N=153 (29%) and MDS N=60 (11%). The mean ODI (SD) in the BDI<1 0 group was 16 (15), in the NmDS group 36 (15), and in the MDS group 41 (18) (p<0.001). The ODI profiles were different between the groups (p<0.001). Pain was more frequent in depressive patients (88% of MDS, 81% in NmDS and 40% in BDI < 10 patients experienced pain, p<0.001). The intensity of pain and pain-related disability was lowest among the patients in the BDI <10 group and highest among the MDS patients. Regular pain medication was used by 87% of patients in the MDS group, 93% of patients in the NmDS group, and 71% of patients in the BDI< 10 group (p<0.001). Response to pain medication with NRS (0–10) was 5.6 among MDS, 5.8 among NmDS and 6.5 among BDI< 10 patients (p<0.001).ConclusionDifferent types of depressive symptoms are associated with poor outcome after lumbar spine surgery. The outcome was worst in patients suffering from the MDS subtype. This was observed in pain intensity, functional disability and response to pain medication.ImplicationIt would be important to evaluate depression pre- and postoperatively. Offering a tailored rehabilitation programme to MDS patients should be considered.© 2016 Scandinavian Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

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“…High comorbidity between depression and obesity in the extant literature is suggestive of shared behavioral and pathophysiological mechanisms [2,3]. With respect to the latter, chronic low grade systemic inflammation has been extensively documented in both obesity [4,5] and depression [6][7][8][9][10][11], and has thus been proposed as possible mechanisms [12,13]. The directionality of this complex association has been examined in at least two ways, Physiology & Behavior 139 (2015) 328-335 depression leading to incident obesity and heightened inflammation, and alternatively, inflammation inherent to obesity leading to incident depression.…”

Section: Introductionmentioning

confidence: 99%