The impact of statins on physical activity and exercise capacity: an overview of the evidence, mechanisms, and recommendations

Schweitzer, Allyson; Gingrich, Molly; Hawke, Thomas J.; Rebalka, Irena A.

doi:10.1007/s00421-020-04360-2

Cited by 10 publications

(6 citation statements)

References 173 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The statin-induced toxicity syndrome is gaining attention because of the drug side effects on muscle tissue. In particular, the effect of myalgia on physical activity may increase the risk of muscle wasting and impair muscle tissue quality [ 16 ]. However, studies on the association between statin use and muscle quantity and function generated contradictory results [ 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Association of chronic statin use, myopenia, myosteatosis and major morbidity in surgical patients with upper gastrointestinal cancer

et al. 2023

View full text Add to dashboard Cite

Derangements of body composition affect surgical outcomes. Chronic statin use may induce muscle wasting and impair muscle tissue quality. Aim of this study was to evaluate the association of chronic statin use, skeletal muscle area (SMA), myosteatosis and major postoperative morbidity. Between 2011 and 2021, patients undergoing pancreatoduodenectomy or total gastrectomy for cancer, and using statins since at least 1 year, were retrospective studied. SMA and myosteatosis were measured at CT scan. The cut-off for SMA and myosteatosis were determined using ROC curve and considering severe complications as the binary outcome. The presence of myopenia was defined when SMA was lower that the cut-off. A multivariable logistic regression was applied to assess the association between several factors and severe complications. After a matching procedure (1:1) for key baseline risk factors (ASA; age; Charlson comorbidity index; tumor site; intraoperative blood loss), a final sample of 104 patients, of which 52 treated and 52 not treated with statins, was obtained. The median age was 75 years, with an ASA score ≥ 3 in 63% of the cases. SMA (OR 5.119, 95% CI 1.053–24.865) and myosteatosis (OR 4.234, 95% CI 1.511–11.866) below the cut-off values were significantly associated with major morbidity. Statin use was predictive of major complication only in patients with preoperative myopenia (OR 5.449, 95% CI 1.054–28.158). Myopenia and myosteatosis were independently associated with an increased risk of severe complications. Statin use was associated with a higher risk of having major morbidity only in the subgroup of patients with myopenia.

show abstract

Section: Discussionmentioning

confidence: 99%

Association of chronic statin use, myopenia, myosteatosis and major morbidity in surgical patients with upper gastrointestinal cancer

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Known as the inducer of ferroptosis, statins target cholesterol synthesis of rate-limiting enzymes (HMG-CoA) (Schweitzer et al, 2020). FSP1-CoQ10-NAD (P) H signaling pathway acted synergistically with GPX4 and GSH to inhibit lipid peroxidation and ferroptosis (Doll et al, 2019).…”

Section: Ferroptosis and Treatment Of Endometrial Cancermentioning

confidence: 99%

Ferroptosis: Opportunities and Challenges in Treating Endometrial Cancer

Zhang

et al. 2022

Front. Mol. Biosci.

View full text Add to dashboard Cite

Ferroptosis, a new way of cell death, is involved in many cancers. A growing number of studies have focused on the unique role of ferroptosis on endometrial cancer. In this study, we made a comprehensive review of the relevant articles published to get deep insights in the association of ferroptosis with endometrial cancer and to present a summary of the roles of different ferroptosis-associated genes. Accordingly, we made an evaluation of the relationships between the ferroptosis-associated genes and TNM stage, tumor grade, histological type, primary therapy outcome, invasion and recurrence of tumor, and accessing the different prognosis molecular typing based on ferroptosis-associated genes. In addition, we presented an introduction of the common drugs, which targeted ferroptosis in endometrial cancer. In so doing, we clarified the opportunities and challenges of ferroptosis activator application in treating endometrial cancer, with a view to provide a novel approach to the disease.

show abstract

“…Studies have shown that exercise training can increase the level of circulating extracellular vesicles [ 117 , 118 ]. These vesicles can transfer metabolic enzymes to the recipient cells, thereby changing metabolism of the recipient tissue [ 119 ].…”

Section: Protective Mechanisms Involved In Ventricular Remodeling Due...mentioning

confidence: 99%

Exercise Training after Myocardial Infarction Attenuates Dysfunctional Ventricular Remodeling and Promotes Cardiac Recovery

Liu¹,

Meng²,

Li³

et al. 2022

Rev. Cardiovasc. Med.

View full text Add to dashboard Cite

Recent evidences have shown that exercise training not only plays a necessary role in maintaining cardiac homeostasis, but also promotes cardiac repair after myocardial infarction. Post-myocardial infarction, exercise training has been observed to effectively increase the maximum cardiac output, and protect myocardial cells against necrosis and apoptosis, thus leading to an improved quality of life of myocardial infarction patients. In fact, exercise training has received more attention as an adjunct therapeutic strategy for both treatment and prevention of myocardial infarction. This review summarizes the experimental evidence of the effects of exercise training in ventricular remodeling after myocardial infarction, and tries to provide theoretical basis along with suitable references for the exercise prescription aimed at prevention and therapy of myocardial infarction.

show abstract

The impact of statins on physical activity and exercise capacity: an overview of the evidence, mechanisms, and recommendations

Cited by 10 publications

References 173 publications

Association of chronic statin use, myopenia, myosteatosis and major morbidity in surgical patients with upper gastrointestinal cancer

Association of chronic statin use, myopenia, myosteatosis and major morbidity in surgical patients with upper gastrointestinal cancer

Ferroptosis: Opportunities and Challenges in Treating Endometrial Cancer

Exercise Training after Myocardial Infarction Attenuates Dysfunctional Ventricular Remodeling and Promotes Cardiac Recovery

Contact Info

Product

Resources

About