The impact of spray drying outlet temperature on the particle morphology of mannitol

Maas, Stephan; Schaldach, Gerhard; Littringer, Eva Maria; Mescher, Axel; Griesser, Ulrich J.; Braun, Doris E.; Walzel, Peter; Urbanetz, Nora Anne

doi:10.1016/j.powtec.2011.06.024

Cited by 132 publications

(81 citation statements)

References 49 publications

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“…α, β, δ [14 -16]. In fact, spray drying of mannitol may produce one or more polymorphic forms with varying morphologies depending on the temperature of drying or the use of adjuvant excipients [1], [17], [18] .…”

Section: Introductionmentioning

confidence: 99%

A pragmatic approach for engineering porous mannitol and mechanistic evaluation of particle performance

Al-Khattawi

Koner

Rue

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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The importance of mannitol has increased recently as an emerging diluent for orodispersible dosage forms. The study aims to prepare spray dried mannitol retaining high porosity and mechanical strength for the development of orally disintegrating tablets (ODTs).Aqueous feed of D-mannitol (10% w/v) comprising ammonium bicarbonate, NH 4 HCO 3 (5% w/v) as pore former was spray dried at inlet temperature of 110-170°C. Compacts were prepared at 20 kN and characterized for porosity, hardness and disintegration time. Particle morphology and drying mechanisms were studied using thermal (HSM, DSC and TGA) and polymorphic (XRD) methods.Tablet porosity increased from 0.20 ± 0.002 for pure mannitol to 0.53 ± 0.03 using fabricated porous mannitol. Disintegration time dropped by 50-77% from 135 ± 5.29 sec for pure mannitol to 75.33 ± 2.52 -31.67 ± 1.53 sec for mannitol 110 -170°C. Hardness increased by 150% at 110°C (258.67 ± 28.89 N) and 30% at 150°C (152.70 ± 10.58 N) compared to pure mannitol tablets (104.17 ± 1.70 N). Increasing inlet temperature resulted in reducing tablet hardness due to generation of 'micro-sponge'-like particles exhibiting significant elastic recovery. Impact of mannitol polymorphism on plasticity/elasticity cannot be ruled out as a mixture of α and β polymorphs formed upon spray drying.

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Section: Introductionmentioning

confidence: 99%

A pragmatic approach for engineering porous mannitol and mechanistic evaluation of particle performance

Al-Khattawi

Koner

Rue

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

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“…Determining the phase diagrams, we obtained the eutectic mixture of xylitol and mannitol confirmed by DSC (90 mass% xylitol and 10 mass% mannitol with the melting temperature of 95.5°C), which coincides with data of Detherm database [21]. Investigating the pastille shell and core structure, we found a phase separation with the eutectic composition of xylitol and mannitol located in the core (Fig.…”

Section: Discussionsupporting

confidence: 81%

“…The literature examples of this type include mannitol-sorbitol [18], xylitol-isomalt [6] and xylitolsorbitol [19]. For xylitol-mannitol, we found eutectic melting temperature [21], but the literature has not any experimental work with this composition. Eutectics are commonly used in drug designing and delivery processes.…”

Section: Introductionmentioning

confidence: 78%

“…Ezeknek a nem redukáló cukroknak van egy olyan közös kedvező tulajdonsága, hogy porlasztva szárítás során megvédik a fehérjéket vagy peptideket a különböző stresszhatásokkal szemben. Helyettesítik a hidrogén kötéseket, amelyeket normál esetben a víz tesz, valamint viszkózus keveréket alkotnak a fehérjével, melynek következ-ményeként magas üvegesedési hőmérsékletű termék keletkezik [21].…”

Section: Porinhalációs Készítmények Formuláláshoz Alkalmazott Segédanunclassified

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Formulation of microcomposites and pastilles using spray-drying and melt technology

Katona¹

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“…Spray drying works by providing a large surface area where heat transfer and atomization of the solution or suspension into small droplets can occur. It is also good at producing a uniform product that is spherical in shape [41]. By spraying the substance into a steam of hot air, the droplet will dry to form individual solid particles at a fast drying rate within milliseconds to a few seconds as a result of the high surface to volume ratio, which prevents phase separation between the drug and polymer components [42].…”

Section: Introductionmentioning

confidence: 99%

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

Adebisi

Kaialy

Hussain

et al. 2016

Colloids and Surfaces B: Biointerfaces

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Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions, Colloids and Surfaces B: Biointerfaces http://dx.doi.org/10. 1016/j.colsurfb.2016.07.032 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 4. GLU improved the handling of PXM as it significantly reduced its charge in all the spray dried formulations. Technique could be used to determine appropriate formulations that improve handling AbstractThis work explores the use of both spray drying and D-glucosamine HCl (GLU) as a hydrophilic carrier to improve the dissolution rate of piroxicam (PXM) whilst investigating the electrostatic charges associated with the spray drying process. Spray dried PXM:GLU solid dispersions were prepared and characterised (XRPD, DSC, SEM). Dissolution and triboelectric charging was also conducted. The results showed that the spray dried PXM alone, without GLU produced some PXM form II (DSC results) with no enhancement in solubility relative to that of the parent PXM.XRPD results also showed the spray drying process to decrease the crystallinity of GLU and solid dispersions produced. The presence of GLU improved the dissolution rate of PXM. Spray dried PXM: GLU at a ratio of 2:1 had the most improved dissolution. The spray drying process generally yielded PXM-GLU spherical particles of around 2.5 µm which may have contributed to the improved dissolution. PXM showed a higher tendency for charging in comparison to the carrier GLU (-3.8 versus 0.5 nC/g for untreated material and -7.5 versus 3.1 nC/g for spray dried materials). Spray dried PXM and spray dried GLU demonstrated higher charge densities than untreated PXM and untreated GLU, respectively. Regardless of PXM:GLU ratio, all spray dried PXM:GLU solid dispersions showed a negligible charge density (net-CMR: 0.1 -0.3 3 nC/g). Spray drying of PXM:GLU solid dispersions can be used to produce formulation powders with practically no charge and thereby improving handling as well as dissolution behaviour of PXM.

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The impact of spray drying outlet temperature on the particle morphology of mannitol

Cited by 132 publications

References 49 publications

A pragmatic approach for engineering porous mannitol and mechanistic evaluation of particle performance

A pragmatic approach for engineering porous mannitol and mechanistic evaluation of particle performance

Formulation of microcomposites and pastilles using spray-drying and melt technology

Solid-state, triboelectrostatic and dissolution characteristics of spray-dried piroxicam-glucosamine solid dispersions

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