The impact of sex hormone concentrations on decision-making in females and males

Derntl, Birgit; Pintzinger, Nina M.; Kryspin-Exner, Ilse; Schöpf, Veronika

doi:10.3389/fnins.2014.00352

Cited by 46 publications

(37 citation statements)

References 60 publications

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“…Whether this difference of representation could have affected our results is unclear and the literature is contradictory about the effect of gender on the performance at decision-making paradigms [72]. In the standard version of the IGT, some differences have been observed between men and women on the deck choice [73].…”

Section: Discussionmentioning

confidence: 99%

Neural Correlates of Successful and Unsuccessful Strategical Mechanisms Involved in Uncertain Decision-Making

et al. 2015

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The ability to develop successful long-term strategies in uncertain situations relies on complex neural mechanisms. Although lesion studies have shown some of the mechanisms involved, it is still unknown why some healthy subjects are able to make the right decision whereas others are not. The aim of our study was to investigate neurophysiological differences underlying this ability to develop a successful strategy in a group of healthy subjects playing a monetary card game called the Iowa Gambling Task (IGT). In this task, subjects have to win and earn money by choosing between four decks of cards, two were advantageous in the long term and two disadvantageous. Twenty healthy right-handed subjects performed the IGT while their cerebral activity was recorded by electroencephalography. Based on their behavioral performances, two groups of subjects could clearly be distinguished: one who selected the good decks and thus succeeded in developing a Favorable strategy (9 subjects) and one who remained Undecided (11 subjects). No neural difference was found between each group before the selection of a deck, but in both groups a greater negativity was found emerging from the right superior frontal gyrus 600 ms before a disadvantageous selection. During the processing of the feedback, an attenuation of the P200 and P300 waveforms was found for the Undecided group, and a P300 originating from the medial frontal gyrus was found in response to a loss only in the Favorable group. Our results suggest that undecided subjects are hyposensitive to the valence of the cards during gambling, which affects the feedback processing.

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Section: Discussionmentioning

confidence: 99%

Neural Correlates of Successful and Unsuccessful Strategical Mechanisms Involved in Uncertain Decision-Making

et al. 2015

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“…Female gonadal hormones, such as estradiol and progesterone (PRO), influence risk-taking behavior (Sukolova and Sarmany-Schuller, 2011; Chavanne and Gallup, 1998; Derntl et al, 2014), and higher levels of estradiol were related to greater impulsivity in the SSRT (Colzato et al, 2010). In animal research, the impact of gonadal hormones on impulsivity has been even less thoroughly examined.…”

Section: Introductionmentioning

confidence: 99%

Progesterone attenuates impulsive action in a Go/No-Go task for sucrose pellets in female and male rats

Swalve

Smethells

Carroll

2016

Hormones and Behavior

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Impulsivity, or a tendency to act without anticipation of future consequences, is associated with drug abuse. Impulsivity is typically separated into two main measures, impulsive action and impulsive choice. Given the association of impulsivity and drug abuse, treatments that reduce impulsivity have been proposed as an effective method for countering drug addiction. Progesterone has emerged as a promising treatment, as it is associated with decreased addiction-related behaviors and impulsive action. The goal of the present study was to determine the effects of progesterone (PRO) on impulsive action for food: a Go/No-Go task. Female and male rats responded for sucrose pellets during a Go component when lever pressing was reinforced on a variable-interval 30-s schedule. During the alternate No-Go component, withholding a lever press was reinforced on a differential reinforcement of other (DRO) behavior 30-s schedule, where a lever press reset the DRO timer. Impulsive action was operationally defined as the inability to withhold a response during the No-Go component (i.e. the number of DRO resets). Once Go/No-Go behavior was stable, responding between rats treated with PRO (0.5 mg/kg) or vehicle was examined. Progesterone significantly decreased the total number of DRO resets in both males and females, but it did not affect VI responding for sucrose pellets. This suggests that PRO decreases motor impulsivity for sucrose pellets without affecting motivation for food. Thus, PRO may reduce motor impulsivity, a behavior underlying drug addiction.

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“…However, these positive associations between testosterone and different indices of risky decision-making have not been unanimously supported. Derntl, Pintzinger, Kryspin-Exner, and Schöpf (2014) failed to find a relationship between testosterone and risky decision-making in both men (n = 45) and women (n = 71), using a battery of laboratory risk-taking measures, including two gambling tasks. Similarly, a study by Zethraeus et al (2009) failed to find a relationship between testosterone and financial risk-aversion, in women.…”

Section: Testosterone Decision-making and Gambling Behaviourmentioning

confidence: 97%

“…However, there are several inconsistencies in this literature. Multiple studies have found null associations between risk-taking and naturally occurring testosterone levels (Derntl et al, 2014;Rosenblitt, Soler, Johnson, & Quadagno, 2001;van der Loos et al, 2013) and high-normal exogenous doses (Boksem et al, 2013;Ortner et al, 2013;Zethraeus et al, 2009). Furthermore, one study has identified clear negative associations between testosterone and several measures of sexual risk-taking attitudes (van Anders, Goldey, Conley, Snipes, & Patel, 2012).…”

Section: Testosterone and Pace Of Playmentioning

confidence: 99%

Slot machine gambling and testosterone: Evidence for a “winner–loser” effect?

Ferrari

Chan²,

Brown³

et al. 2018

Psychology of Addictive Behaviors

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The “winner–loser effect” refers to a phenomenon in testosterone research where the outcome of a social competition induces increases (wins) and/or decreases (losses) in testosterone levels. Here, we sought to test to what extent changes in testosterone occur in response to gambling behavior. More specifically, we hypothesized that the winner–loser effect would extend to slot machine gambling as a solitary (noncompetitive) gambling activity in players who “anthropomorphized” the slot machine, thus treating the machine as a human opponent. Male participants (n = 113) were recruited into a quasi-experimental design involving 15 min of authentic slot machine gambling, incentivized by a $10 cash bonus for participants who finished in profit. In addition to salivary measures of testosterone, salivary cortisol and self-reported anthropomorphization of the slot machine were tested as potential moderators. Contrary to predictions, winning and losing slot machine sessions did not exert significant differential effects on testosterone, and this pattern was not moderated by cortisol levels or slot machine anthropomorphization. Exploratory analyses tested relationships between subjective gambling experiences in the sessions and testosterone change. Higher positive affect and flow predicted greater testosterone declines from pre- to postgambling. The testosterone results add to a growing literature on the boundary conditions of the winner–loser effect and inform future studies on testosterone reactivity in relation to gambling and disordered gambling. The tendency to anthropomorphize slot machines is a neglected cognitive distortion in gambling that merits further study.

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The impact of sex hormone concentrations on decision-making in females and males

Cited by 46 publications

References 60 publications

Neural Correlates of Successful and Unsuccessful Strategical Mechanisms Involved in Uncertain Decision-Making

Neural Correlates of Successful and Unsuccessful Strategical Mechanisms Involved in Uncertain Decision-Making

Progesterone attenuates impulsive action in a Go/No-Go task for sucrose pellets in female and male rats

Slot machine gambling and testosterone: Evidence for a “winner–loser” effect?

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