The Impact of Sex and Gender on the Multidisciplinary Management of Care for Persons With Parkinson's Disease

Göttgens, Irene; Halteren, Angelika D. van; Vries, Nienke M. de; Meinders, Marjan J.; Ben‐Shlomo, Yoav; Bloem, Bastiaan R.; Darweesh, Sirwan K.L.; Oertelt‐Prigione, Sabine

doi:10.3389/fneur.2020.576121

Cited by 23 publications

(19 citation statements)

References 75 publications

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“…Women may also experience significant side effects that were not seen in the study population dominated by men that participated in the original seeding trials. Such differences have also been observed in PD [31].…”

Section: Relevance Of Researchsupporting

confidence: 65%

Ethical Aspects of Personal Science for Persons with Parkinson’s Disease: What Happens When Self-Tracking Goes from Selfcare to Publication?

Riggare

Hägglund

Bredenoord

et al. 2021

JPD

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Using Parkinson’s disease as an exemplary chronic condition, this Commentary discusses ethical aspects of using self-tracking for personal science, as compared to using self-tracking in the context of conducting clinical research on groups of study participants. Conventional group-based clinical research aims to find generalisable answers to clinical or public health questions. The aim of personal science is different: to find meaningful answers that matter first and foremost to an individual with a particular health challenge. In the case of personal science, the researcher and the participant are one and the same, which means that specific ethical issues may arise, such as the need to protect the participant against self-harm. To allow patient-led research in the form of personal science in the Parkinson field to evolve further, the development of a specific ethical framework for self-tracking for personal science is needed.

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Section: Relevance Of Researchsupporting

confidence: 65%

Ethical Aspects of Personal Science for Persons with Parkinson’s Disease: What Happens When Self-Tracking Goes from Selfcare to Publication?

Riggare

Hägglund

Bredenoord

et al. 2021

JPD

Self Cite

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“…We also included sex to explore if disease-related changes in sensorimotor oscillatory activity differed between males and females, as there are well-documented sex differences in the manifestation of PD. 1,65 Male sex is a risk factor for developing PD, with an average incidence ratio of approximately 2:1 male-female ratio across all stages of the disease. 66 The disease onset is on average two years earlier in males than females and differs in the initial manifestation of symptoms, with women more likely to develop tremor specific symptoms and men more likely to develop rigidity.…”

Section: Discussionmentioning

confidence: 99%

Changes in non-oscillatory features of the cortical sensorimotor rhythm in Parkinson’s disease across age

Vinding

Eriksson

Ting

et al. 2021

Preprint

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Parkinson's disease (PD) is associated with functional changes in the neural activity within the brain's sensorimotor network, which in turn are related to the characteristic motor symptoms in PD. The functional changes in PD are particularly prominent in terms of oscillatory neuronal activity in the characteristic sensorimotor alpha and beta rhythms. However, summaries in terms of alpha or beta power do not capture the full range of the complex dynamic nature of the signals from the somatosensory cortex. This raises the question of how to quantify and summarise the functional changes in such oscillatory features in a manner that captures the relevant disease- and symptom-related neural activity. We investigated the role of spontaneous cortical somatosensory activity in the electrophysiological alpha and beta bands among a cohort of early- to mid-stage PD patients (N=78) and age- and gender-matched healthy controls (N=60) using source reconstructed resting-state magnetoencephalography (MEG) recordings. We quantified the oscillatory features of the neural time series by its oscillatory alpha power, beta power, and 1/f broadband characteristics using power spectral density, and additionally by characterising "burst" properties in the signals. We examined the relationship between the signal features and disease state, age, sex, and cortical thickness. Using multiple regression, we examined the relative contribution of the oscillatory features on the clinical manifestation of motor symptoms in the PD group. Our results show that PD patients differ from healthy controls on several of the oscillatory features, showing higher beta-band power, higher burst amplitude, and steeper 1/f broadband characteristics compared to healthy controls, as well as a steeper age-related decrease in the bursts rate. While there was a high degree of correlation between some of the oscillatory features, several features also appeared functionally separated, showing independent feature-to-symptom relationships. For instance, oscillatory beta power increased with the severity of midline function symptoms, while burst rate decreased with the severity of bradykinesia. Our study shows that quantification of distinct features within the oscillatory sensorimotor neural time series in PD captures different underlying mechanisms related to disease progression and symptom severity, which in turn has a potential for a more individualised and precision-based approach to assessing functional neural changes in PD.

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“…Sleep disorders are also common in PD, and inconsistent with the results of clinical studies, the prevalence has been reported to be higher in men than in women ( 26 , 27 ). Based on the sex-related effects of PD on non-motor symptoms, female PD patients should pay more attention to negative emotions, for which they may need guidance from clinical staff and caregivers ( 28 ).…”

Section: Discussionmentioning

confidence: 99%

Findings in Chinese Patients With Parkinson's Disease: A Content Analysis From the SML Study

Qian

Zhang

et al. 2021

Front. Psychiatry

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Social media listening (SML) is a new process for obtaining information from social media platforms to generate insights into users' experiences and has been used to analyze discussions about a multitude of diseases. To understand Parkinson's disease patients' unmet needs and optimize communication between doctors and patients, social media listening was performed to investigate concerns in Chinese patients. A comprehensive search of publicly available social media platforms with Chinese-language content posted between January 2005 and April 2019 in mainland China was performed using defined Parkinson's disease-related terms. After multiple steps of machine screening were performed, a series of posts were derived. The content was summarized and classified manually to analyze and map psychological insights, and descriptive statistics were applied to aggregate findings. A total of 101,899 patient-related posts formed the basis of this study. The topics mainly focused on motor symptoms (n = 54,983), choice of pharmaceutical drugs (n = 45,203) and non-motor symptoms (n = 44,855). The most common symptoms mentioned were tremor (54.5%), pain (22.9%), and rigidity (22.1%). Psychological burden (51%) and work/social burden (48%) were the most concerning burdens for patients and their families. The compound levodopa (43%) and dopamine agonists (23%) were the most common options for the patients, while concerns about new-generation anti-Parkinson's disease medication increased. The portraits of patients suggested varying characteristics across different periods and advocate for personalized service from doctors. In the management of patients, it is imperative to plan individualized therapy and education strategies as well as strategies for social support.

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The Impact of Sex and Gender on the Multidisciplinary Management of Care for Persons With Parkinson's Disease

Cited by 23 publications

References 75 publications

Ethical Aspects of Personal Science for Persons with Parkinson’s Disease: What Happens When Self-Tracking Goes from Selfcare to Publication?

Ethical Aspects of Personal Science for Persons with Parkinson’s Disease: What Happens When Self-Tracking Goes from Selfcare to Publication?

Changes in non-oscillatory features of the cortical sensorimotor rhythm in Parkinson’s disease across age

Findings in Chinese Patients With Parkinson's Disease: A Content Analysis From the SML Study

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