The impact of sarcobesity on incisional hernia after laparoscopic colorectal cancer surgery

Takano, Yasuhiro; Kodera, Keita; Tsukihara, Shu; Takahashi, Sumika; Yasunobu, Kobayashi; Kanno, Hironori; Saito, Ryota; Hanyu, Nobuyoshi

doi:10.1007/s00384-023-04424-7

Cited by 2 publications

(2 citation statements)

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“…8,30 Additionally, Takano et al identified sarcobesity, characterized by the simultaneous presence of visceral obesity, sarcopenia, and wound infection as independent indicators of incisional hernia in multivariate analysis after laparoscopic colorectal cancer surgery. 9 The debate persists regarding whether abdominal subcutaneous or visceral obesity plays a predominant role in IH development. It is worth noting the association between obesity and surgical site infection, and surgical site infection will lead to the occurrence of VH.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 Evidence of these observational studies was based on small sample sizes and therefore might not fully confirm the causal relationship between adiposity distribution and VH. 8,9 Mendelian randomization (MR) is an ideal strategy to address these limitations. 10 This approach assesses the causal relationship between exposures and outcomes by imitating randomized controlled trials, using measured variants in genes of known function in observational data as proxies (also called instrumental variables, [IVs]) for exposure (e.g., disease, lifestyle, etc.).…”

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confidence: 99%

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Causal relationship of obesity and adiposity distribution on risk of ventral hernia

Shi,

Wu,

Guo

et al. 2024

World j. surg.

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PurposeVentral hernia (VH) is a common surgical disease. Previous studies suggested that obesity is an important risk factor for VH. However, the causal relationship between fat distribution and the risk of VH is still unclear. This study used Mendelian randomization (MR) to evaluate their causal relationship.MethodsWe used the body mass index (BMI), body fat percentage, and body fat mass to represent general obesity and utilized the volume of abdominal subcutaneous adiposity tissue, visceral adiposity tissue, waist circumference, hip circumference, and waist‐to‐hip ratio to represent abdominal adiposity. The data were extracted from the large‐scale genome‐wide association study of European ancestry. We used two‐sample MR to infer causality, using multivariate MR to correct the effects of confounding factors.ResultsIncreased BMI, body fat percentage, body fat mass, visceral adiposity tissue, waist circumference, and hip circumference rather than subcutaneous adiposity tissue or waist‐to‐hip ratio, were causally associated with a higher risk of VH. The results of multivariate MR suggested that body fat percentage was causally associated with a higher risk of VH after adjusting for body mass index, diabetes, and smoking.ConclusionGeneral obesity, increased visceral adiposity tissue, waist circumference, and hip circumference rather than subcutaneous adiposity tissue or the waist‐to‐hip ratio were causally associated with a higher risk of VH. These findings provided a deeper understanding of the role that the distribution of adiposity plays in the mechanism of VH.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%