The Impact of Rotating Night Shift Work and Daytime Recharge on Cognitive Performance Among Retired Nurses

Gan, Jinghuan; Wang, Xiaodan; Shi, Zhihong; Yuan, Junliang; Zhang, Meiyun; Liu, Shuai; Wang, Fei; You, Yong; Jia, Peifei; Feng, Lisha; Xu, Jiankun; Zhang, Jinhong; Hu, Wenzheng; Chen, Zhichao; Ji, Yong

doi:10.3389/fnagi.2021.827772

Cited by 5 publications

(2 citation statements)

References 64 publications

(68 reference statements)

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“…The synthesis of serotonin is a multistep process, beginning in the terminals of serotonergic neurons, L‐tryptophan is hydroxylated by tryptophan hydroxylase (Tph), converting it into 5‐hydroxytryptophan (5‐HTP) [105, 106]. 5‐HTP is then catalyzed by aromatic amino acid decarboxylase (AAAD) into serotonin [106].…”

Section: Serotoninmentioning

confidence: 99%

Circadian dysregulation and Alzheimer’s disease: A comprehensive review

Iacobelli

2022

Brain Science Advances

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Alzheimer’s disease (AD), the foremost variant of dementia, has been associated with a menagerie of risk factors, many of which are considered to be modifiable. Among these modifiable risk factors is circadian rhythm, the chronobiological system that regulates sleep‐wake cycles, food consumption timing, hydration timing, and immune responses amongst many other necessary physiological processes. Circadian rhythm at the level of the suprachiasmatic nucleus (SCN), is tightly regulated in the human body by a host of biomolecular substances, principally the hormones melatonin, cortisol, and serotonin. In addition, photic information projected along afferent pathways to the SCN and peripheral oscillators regulates the synthesis of these hormones and mediates the manner in which they act on the SCN and its substructures. Dysregulation of this cycle, whether induced by environmental changes involving irregular exposure to light, or through endogenous pathology, will have a negative impact on immune system optimization and will heighten the deposition of Aβ and the hyperphosphorylation of the tau protein. Given these correlations, it appears that there is a physiologic association between circadian rhythm dysregulation and AD. This review will explore the physiology of circadian dysregulation in the AD brain, and will propose a basic model for its role in AD‐typical pathology, derived from the literature compiled and referenced throughout.

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Section: Serotoninmentioning

confidence: 99%

Circadian dysregulation and Alzheimer’s disease: A comprehensive review

Iacobelli

2022

Brain Science Advances

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“…Up to date, there is growing concern over the impact of shift work on nurses' cognitive and executive performance (Dönmezdil & Araç, 2021; Esmaily et al, 2021; Gan et al, 2021; Guyette et al, 2013; James et al, 2021; Kaliyaperumal et al, 2017; Merchaoui et al, 2017; Rhéaume & Mullen, 2018; Veal et al, 2021; Zion & Shochat, 2018). Some results among these studies are helpful for nurse managers to implement or change specific medical strategies.…”

Section: Introductionmentioning

confidence: 99%

Effect of shift work on fatigue, reaction time and accuracy of nurses in the Department of Neurology: A cross‐sectional observational study

et al. 2022

J Nursing Management

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Aims The purpose of our study was mainly to explore the effect of different shift work on cognitive and executive performance in a real clinical environment among nurses from China. Background Working in shifts can disrupt circadian rhythm, resulting in reduced sleep duration, which can have a detrimental effect on cognitive function. To provide continuous service for patient care, shift work is often a special requirement for nurses. The Stroop test can be used to measure selective attention and reaction time during executive function. However, there have been limited studies about the effect of shift work on the cognitive performance of nurses by Stroop tests. Additionally, no study has been conducted in nurses working in shifts from China. Methods Registered nurses in general ward, Department of Neurology, from West China Hospital of Sichuan University, were eligible and consecutively included if they were simultaneously responsible for the day, evening and night shifts on the shift work schedule. A fatigue questionnaire and Stroop tests were performed for each subject separately before and after three working shifts (morning, evening and night shift) to measure changes in fatigue, reaction time and accuracy. Results Eighteen registered nurses (4 males and 14 females) were included in our study, with a median age of 25 years old. The fatigue degree was significantly increased after day and evening shifts (p = .015 and <.001, respectively). Compared with those in the preshifts, the reaction time in the neutral task and incongruent task was significantly quicker after the day shift (p = .001, p < .001) and night shift (p = .008, .019). In contrast, the reaction time after the evening shift was mildly increased, although without significance. There was no significant difference in accuracy among the three different working shifts. In addition, there was a negative correlation between the fatigue score and reaction time on the incongruent task in the Stroop test before the day shift (r = −.542, p = .020). The fatigue score in the postday shift was found to be inversely related to working hours in the daytime (r = −.500, p = .034). Conclusions Our study showed that increased fatigue was found in nurses after day and evening shifts, and shift work can affect the reaction time after the evening shift. However, there was no significant difference in accuracy and a high level of attention could be maintained among the three working shifts, suggesting a highly developed sense of responsibility in our nurses. Implications for Nursing Management In addition to focusing on the common adverse effects of evening or night shifts on nurses, fatigue in the day shift should be paid special attention to by the leadership in the nursing management. Also, nurse managers can implement specific strategies to reduce fatigue after the day shift by shortening the working hours in the daytime appropriately, setting rest periods in the day shift or dividing nurses into morning and afternoon shifts.

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