The impact of RNA modifications on the biology of DNA virus infection

Rajendren, Suba; Karijolich, John

doi:10.1016/j.ejcb.2022.151239

Cited by 5 publications

(1 citation statement)

References 182 publications

(216 reference statements)

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“…Furthermore, viral genotyping might provide valuable insights in selecting appropriate anti-viral medicines and forecasting their effectiveness against certain strains of HBV. Incorporating these individualized characteristics into treatment determinations can optimize treatment results, mitigate unfavorable consequences, and increase patients’ overall quality of life[ 110 , 154 ]. The progress of personalized medicine can significantly impact the management of HBV reactivation by introducing patient-specific treatment approaches.…”

Section: Management Strategies For Hbv Reactivationmentioning

confidence: 99%

Overview of the immunological mechanisms in hepatitis B virus reactivation: Implications for disease progression and management strategies

Ma,

Yan,

et al. 2024

World J Gastroenterol

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Hepatitis B virus (HBV) reactivation is a clinically significant challenge in disease management. This review explores the immunological mechanisms underlying HBV reactivation, emphasizing disease progression and management. It delves into host immune responses and reactivation’s delicate balance, spanning innate and adaptive immunity. Viral factors’ disruption of this balance, as are interactions between viral antigens, immune cells, cytokine networks, and immune checkpoint pathways, are examined. Notably, the roles of T cells, natural killer cells, and antigen-presenting cells are discussed, highlighting their influence on disease progression. HBV reactivation’s impact on disease severity, hepatic flares, liver fibrosis progression, and hepatocellular carcinoma is detailed. Management strategies, including anti-viral and immunomodulatory approaches, are critically analyzed. The role of prophylactic anti-viral therapy during immunosuppressive treatments is explored alongside novel immunotherapeutic interventions to restore immune control and prevent reactivation. In conclusion, this comprehensive review furnishes a holistic view of the immunological mechanisms that propel HBV reactivation. With a dedicated focus on understanding its implications for disease progression and the prospects of efficient management strategies, this article contributes significantly to the knowledge base. The more profound insights into the intricate interactions between viral elements and the immune system will inform evidence-based approaches, ultimately enhancing disease management and elevating patient outcomes. The dynamic landscape of management strategies is critically scrutinized, spanning anti-viral and immunomodulatory approaches. The role of prophylactic anti-viral therapy in preventing reactivation during immunosuppressive treatments and the potential of innovative immunotherapeutic interventions to restore immune control and proactively deter reactivation.

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Section: Management Strategies For Hbv Reactivationmentioning

confidence: 99%

Overview of the immunological mechanisms in hepatitis B virus reactivation: Implications for disease progression and management strategies

Ma,

Yan,

et al. 2024

World J Gastroenterol

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“Transfer” of power: The intersection of DNA virus infection and tRNA biology

Dremel

Jimenez

Tucker

2023

Seminars in Cell & Developmental Biology

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The cellular and KSHV A-to-I RNA editome in primary effusion lymphoma and its role in the viral lifecycle

et al. 2023

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Adenosine-to-inosine RNA editing is a major contributor to transcriptome diversity in animals with far-reaching biological consequences. Kaposi’s sarcoma-associated herpesvirus (KSHV) is the etiological agent of several human malignancies including primary effusion lymphoma (PEL). The extent of RNA editing within the KSHV transcriptome is unclear as is its contribution to the viral lifecycle. Here, we leverage a combination of biochemical and genomic approaches to determine the RNA editing landscape in host- and KSHV transcriptomes during both latent and lytic replication in PEL. Analysis of RNA editomes reveals it is dynamic, with increased editing upon reactivation and the potential to deregulate pathways critical for latency and tumorigenesis. In addition, we identify conserved RNA editing events within a viral microRNA and discover their role in miRNA biogenesis as well as viral infection. Together, these results describe the editome of PEL cells as well as a critical role for A-to-I editing in the KSHV lifecycle.

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The impact of RNA modifications on the biology of DNA virus infection

Cited by 5 publications

References 182 publications

Overview of the immunological mechanisms in hepatitis B virus reactivation: Implications for disease progression and management strategies

Overview of the immunological mechanisms in hepatitis B virus reactivation: Implications for disease progression and management strategies

“Transfer” of power: The intersection of DNA virus infection and tRNA biology

The cellular and KSHV A-to-I RNA editome in primary effusion lymphoma and its role in the viral lifecycle

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