The impact of response to previous mood stabilizer therapy on response to olanzapine versus placebo for acute mania

Baker, Robert W.; Goldberg, Joseph F.; Tohen, M.; Milton, Denái R.; Stauffer, Virginia L.; Schuh, Leslie M.

doi:10.1034/j.1399-5618.2002.40103.x

Cited by 13 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Combined drug regimens are common in patients with bipolar disorder. 5,6,33 Combined use of lamotrigine and olanzapine is likely, and information regarding a potential drug interaction-or the lack of interaction-is important for clinicians who treat patients with bipolar disorder.…”

Section: Discussionmentioning

confidence: 99%

Lack of Pharmacokinetic Interaction Between Lamotrigine and Olanzapine in Healthy Volunteers

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Lack of Pharmacokinetic Interaction Between Lamotrigine and Olanzapine in Healthy Volunteers

et al. 2006

View full text Add to dashboard Cite

show abstract

“…In patients refractory to lithium, valproate, or carbamazepine, it is beneficial to add haloperidol, olanzapine, quetiapine, aripiprazole, or asenapine ( Szegedi et al, 2012 ) ( Sachs et al, 2002 , 2004 ; Tohen et al, 2002b ; Yatham et al, 2007 ; Vieta et al, 2008b ) but not ziprasidone, topiramate, risperidone, or paliperidone ( Roy Chengappa et al, 2006 ; Berwaerts et al, 2011 ; Sachs et al, 2012a , 2012b ; Moosavi et al, 2014 ). One study that used a mixed population with some patients entering after a minimum of 2 weeks of mood stabilizer therapy, and others starting a mood stabilizer and risperidone in parallel, provided inconclusive data for risperidone ( Yatham et al, 2003 ) as the results were likely confounded by the effects of carbamazepine on serum levels of risperidone.…”

Section: Efficacy Datamentioning

confidence: 99%

The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm

Fountoulakis

Yatham

Grunze

et al. 2016

IJNPPY

View full text Add to dashboard Cite

Background:The current paper includes a systematic search of the literature, a detailed presentation of the results, and a grading of treatment options in terms of efficacy and tolerability/safety.Material and Methods:The PRISMA method was used in the literature search with the combination of the words ‘bipolar,’ ‘manic,’ ‘mania,’ ‘manic depression,’ and ‘manic depressive’ with ‘randomized,’ and ‘algorithms’ with ‘mania,’ ‘manic,’ ‘bipolar,’ ‘manic-depressive,’ or ‘manic depression.’ Relevant web pages and review articles were also reviewed.Results:The current report is based on the analysis of 57 guideline papers and 531 published papers related to RCTs, reviews, posthoc, or meta-analysis papers to March 25, 2016. The specific treatment options for acute mania, mixed episodes, acute bipolar depression, maintenance phase, psychotic and mixed features, anxiety, and rapid cycling were evaluated with regards to efficacy. Existing treatment guidelines were also reviewed. Finally, Tables reflecting efficacy and recommendation levels were created that led to the development of a precise algorithm that still has to prove its feasibility in everyday clinical practice.Conclusions:A systematic literature search was conducted on the pharmacological treatment of bipolar disorder to identify all relevant random controlled trials pertaining to all aspects of bipolar disorder and graded the data according to a predetermined method to develop a precise treatment algorithm for management of various phases of bipolar disorder. It is important to note that the some of the recommendations in the treatment algorithm were based on the secondary outcome data from posthoc analyses.

show abstract

“…Meta-analytical studies suggest that olanzapine is effective against dysphoric mania concerning both manic and depressive symptoms and irrespective of factors like sex, age at onset, rapid cycling or psychotic features (Baldessarini et al, 2003a) or prior history of good or poor response to lithium or anticonvulsants (Baker et al, 2002). The overall response rate is superior to placebo (55 % vs. 29.5 %) (Chengappa et al, 2003).…”

Section: Acute Maniamentioning

confidence: 99%

Treatment of bipolar disorder: a systematic review of available data and clinical perspectives

Fountoulakis¹,

Vieta²

2008

Int. J. Neuropsychopharm.

151

105

View full text Add to dashboard Cite

This paper is a systematic review of the available data concerning the treatment of bipolar disorder: a systematic Medline search concerning treatment guidelines and clinical trials. The search for treatment guidelines returned 583 articles and 913 papers for RCTs. The search was last performed on 1 March 2008. An additional search included repositories of clinical trials and previous systematic reviews in order to trace especially older trials. The literature suggests that lithium is useful during the acute manic and the maintenance phase. Both first- and second-generation antipsychotics are efficacious in the treatment of acute mania. Quetiapine and the olanzapine-fluoxetine combination are also effective for treating bipolar depression, while olanzapine, quetiapine and aripiprazole are effective during the maintenance phase. Anticonvulsants, particularly valproate and carbamazepine have antimanic properties, whereas lamotrigine may be preferably effective in the treatment of depression but not mania. Antidepressants should always be used in combination with an antimanic agent because they were reported to induce switching to mania or hypomania, mixed episodes, and rapid cycling when given as monotherapy. The best evidence-based psychosocial interventions for bipolar disorder are group- and family-focused psychoeducation. Electroconvulsive therapy is an option for refractory patients. Although a variety of treatment options for bipolar disorder is currently available, their effectiveness is far from satisfactory, especially against bipolar depression and maintenance. Combination therapy may improve treatment outcome but it also carries the burden of more side-effects. Further research as well as the development of better guidelines and algorithms for step-by-step rational treatment are necessary.

show abstract

The impact of response to previous mood stabilizer therapy on response to olanzapine versus placebo for acute mania

Cited by 13 publications

References 16 publications

Lack of Pharmacokinetic Interaction Between Lamotrigine and Olanzapine in Healthy Volunteers

Lack of Pharmacokinetic Interaction Between Lamotrigine and Olanzapine in Healthy Volunteers

The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm

Treatment of bipolar disorder: a systematic review of available data and clinical perspectives

Contact Info

Product

Resources

About