The Impact of Resolution of Inflammation on Tumor Microenvironment: Exploring New Ways to Control Cancer Progression

Liotti, Federica; Marotta, Maria; Melillo, Rosa Marina; Prevete, Nella

doi:10.3390/cancers14143333

Cited by 8 publications

(4 citation statements)

References 152 publications

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“…A high NLR reflects an increased neutrophil response and a decreased lymphocyte response to the tumor. Neutrophils play an important role in cancer progression, angiogenesis, epithelial–mesenchymal transition (EMT), and immunosuppression [ 38 , 39 ]. In GC cell line analysis, neutrophils at invasive lesions regulate tumor angiogenesis via matrix metalloproteinase-9 [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Effects of the Neutrophil-to-Lymphocyte Ratio/Serum Albumin Ratio in Patients with Gastric Cancer after Gastrectomy

Onuma

Hashimoto

Suematsu

et al. 2023

JPM

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Preoperative inflammatory and nutritional statuses have potential prognostic effects on patients with gastric cancer (GC) after curative gastrectomy. We investigated the prognostic usefulness of the preoperative neutrophil-to-lymphocyte ratio/albumin ratio (NLR/Alb) in patients with GC. Among 483 patients who underwent gastrectomy for GC, the preoperative prognostic nutritional index (PNI), NLR, and NLR/Alb were calculated using preoperative blood test data. The patients were divided into the high and low PNI, NLR, and NLR/Alb groups. The associations of preoperative PNI, NLR, and NLR/Alb with clinicopathological features, 3-year (3Y) overall survival (OS) rates, and relapse-free survival (RFS) rates after gastrectomy for GC were evaluated. The number of female individuals and the C-reactive protein levels were significantly higher in the high- compared to the low-NLR/Alb group (both p < 0.05). The 3Y OS and 3Y RFS rates following gastrectomy were significantly lower in the high- compared to the low-NLR/Alb group (88.2% vs. 97.8%, p = 0.003 and 84.2% vs. 95.6%, p = 0.002, respectively). In multivariate analysis, high NLR/Alb could independently predict prognosis and recurrence (hazard ratio [HR]: 4.13; 95% confidence interval [CI]: 1.26–13.55; p = 0.02 and HR: 3.16; 95% CI: 1.34–7.45, p = 0.009, respectively). Preoperative NLR/Alb might be a useful prognostic factor for patients with GC after curative gastrectomy.

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Section: Discussionmentioning

confidence: 99%

Clinical Effects of the Neutrophil-to-Lymphocyte Ratio/Serum Albumin Ratio in Patients with Gastric Cancer after Gastrectomy

Onuma

Hashimoto

Suematsu

et al. 2023

JPM

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“…In conclusion, although a limited number of studies were collected in the present Research Topic, it is clear that the Endocrine Cancer Microenvironment represents a major target for developing novel anti-cancer strategies. Currently available evidences have consistently supported the concept that cancer progression is promoted by the complex interplay between malignant cells and the surrounding environment (17)(18)(19). Tumor related inflammation represents the common denominator but genetic aspects, specific cellular types and soluble molecules within the TME may all represent potential reliable models for future research.…”

Section: Soluble Mediators In the Tmementioning

confidence: 98%

Editorial: Further advances in understanding the endocrine cancer microenvironment

2022

Self Cite

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Inflammation is a physiologic process occurring in response to tissue damage. Already in 1863, Virchow (1, 2), based on the observation that leukocytes infiltrate neoplastic tissues, hypothesized a relationship between inflammation and cancer. The demonstration that inflammation promotes tumor genome instability, cell growth, survival, invasion and angiogenesis has led to the current notion that inflammation is an essential component of malignancies (1) suggesting that it could represent a target for cancer therapy.More recently, the term tumor microenvironment (TME) was used to include both cellular and soluble components which surround and infiltrate the tumor mass (3). The TME is composed of extracellular matrix and stromal cells, including fibroblasts, vessel cells (endothelial cells, pericytes, and smooth muscle cells), and inflammatory leukocytes (lymphocytes, macrophages, dendritic cells, mast cells, and neutrophils), while soluble mediators include a wide spectrum of chemokines, cytokines, and growth factors, which are secreted by both resident tumor and surrounding normal cells as well as by infiltrating immune cells (4-6).It progressively became clear that both the phenotype and the number of infiltrating cells are strongly dependent upon specific chemokines secreted within the TME. Thus, chemokines rapidly became among the most extensively characterized molecules involved in the maintenance and progression of tumor-related inflammation (7).In the five articles included in this Research Topic, different aspects of the most recent lines of research on the field of TME and cancer biology were addressed. The findings are here briefly overviewed with the final aim to provide a stimulating summary of the present knowledge.

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“…В то же время при злокачественных новообразованиях наблюдается угнетение синтеза специализированных проразрешающих медиаторов, обладающих мощным противовоспалительным действием [33,35]. К ЗНО, при которых описана защитная роль СпРМ, относятся рак полости рта, желудка, толстой кишки, поджелудочной железы, печени, легких, меланома [36].…”

Section: участие медиаторов жировой ткани регулирующих течение воспал...unclassified

Association of adipose tissue mediators with the development of cancer in patients with metabolic syndrome

Sereda,

Chernyshova,

Mamonova

et al. 2024

Sib. onkol. ž.

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The aim of the study was to summarize the available data on the relationship between adipose tissue mediators and cancer in patients with metabolic syndrome. Material and methods. A literature search was conducted using the PubMed and eliBRARY databases. Of the 400 articles published over the past 20 years, 58 studies were included in the review. Results. There is evidence of an unfavorable course of cancer in patients with metabolic syndrome that is explained by the presence of common pathogenetic pathways. In this review, special attention is paid to adipose tissue mediators that regulate the course of inflammation. The involvement of adipose tissue mediators in the pathogenesis of cancer is discussed. The relationship between adipokines of adipose tissue and the effects of specialized pro-resolving mediators (SpRM), which are metabolites of polyunsaturated fatty acids (resolvins, protectins and maresins), are considered. the associations of mediators that regulate the intensity of inflammation with the metabolic syndrome and cancer are discussed. Conclusion. Further studies will contribute to a better understanding of the relationship between metabolic syndrome and cancer and the search for adequate predictive markers to select the most effective drug strategy for correcting metabolic syndrome.

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The Impact of Resolution of Inflammation on Tumor Microenvironment: Exploring New Ways to Control Cancer Progression

Cited by 8 publications

References 152 publications

Clinical Effects of the Neutrophil-to-Lymphocyte Ratio/Serum Albumin Ratio in Patients with Gastric Cancer after Gastrectomy

Clinical Effects of the Neutrophil-to-Lymphocyte Ratio/Serum Albumin Ratio in Patients with Gastric Cancer after Gastrectomy

Editorial: Further advances in understanding the endocrine cancer microenvironment

Association of adipose tissue mediators with the development of cancer in patients with metabolic syndrome

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