The impact of resistant strains of mycobacterium tuberculosis on relapse of tuberculosis

Videnović-Ivanov, Jelica; Vučinić-Mihailović, Violeta; Mandaric, D.

doi:10.2298/mpns0612522v

Cited by 1 publication

(7 citation statements)

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“…A special problem in the 21st century is the outbreak of extremely drug-resistant tuberculosis (XDR TB), recorded in 23 countries; however, it is believed to be present to a much greater extent [9][10][11][12][13].…”

Section: The Magnitude Of Tuberculosis Problem Worldwidementioning

confidence: 99%

“…MDR represents the most severe form of bacterial resistance. MDR tuberculosis is, therefore, a significant problem for tuberculosis control in many countries [2,8,10,11,15].…”

Section: Defining the Antituberculotic Resistant Casesmentioning

confidence: 99%

“…The WHO has clearly defined not only the categories of resistant tuberculosis but also the categories of TB patients, regimes and outcomes of their treatment, which should always be respected within the successful national program of tuberculosis control [8][9][10].…”

Section: Defining the Antituberculotic Resistant Casesmentioning

confidence: 99%

“…During the initial phase of tuberculosis control national program implementation, the old cases (previously inadequately treated or treated by non-standardized chemotherapy regimes) can represent up to a half of the recorded cases. Thus, acquired resistance emerges as the priority problem, and its degree is 50% to 80% in previously treated patients [2,4,7,10,12,15].…”

Section: Defining the Antituberculotic Resistant Casesmentioning

confidence: 99%

“…Therefore, the successful therapy always means the administration of several drugs, mono-therapy is never used, the drugs are always used in full therapeutic dose and long enough in order to affect all the metabolically more or less active bacilli, inside or outside the cells. Administration of one drug or of inadequate drug combination results in the development of resistance in two or three weeks [2, [8][9][10]14,17].…”

Section: How Does Mdr Tuberculosis Originatementioning

confidence: 99%

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Tuberculosis in the 21st century: Challenges, endeavors and recommendations to doctors

Ristic¹,

Rančić²,

Radović³

2010

Med pregl

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The magnitude of problem with tuberculosis lies in the fact that one third of the world population is infected by Mycobacterium tuberculosis. Even in the 21st century, tuberculosis kills more people than any other infective agent. Definition of case of resistance--the case of resistant tuberculosis is precisely defined by the recommendations of the World Health Organization as primary, initial, acquired multidrug resistant and extensively drug resistant tuberculosis. The development of resistance tuberculosis may result from the administration of mono-therapy or inadequate combinations of anti-tuberculosis drugs. A possible role of doctors in the development of multi drug-resistant tuberculosis is very important. Actually, multi drug-resistant tuberculosis is a direct consequence of mistakes in prescribing chemotherapy, provision of anti-tuberculosis drugs, surveillance of the patient and decision-making regarding further treatment as well as in a wrong way of administration of anti-tuberculosis drugs. The problem of extensively drug-resistant tuberculosis in the world has become very alarming. In South Africa, extensively drug resistant tuberculosis accounts for 24% of all tuberculosis case. It can be concluded that only adequate treatment according to directly supervised short regiment for correctly categorized cases of tuberculosis can stop the escalation of multidrug or extensively drug resistant tuberculosis, which is actually an incurable illness in the 21st century.

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Section: The Magnitude Of Tuberculosis Problem Worldwidementioning

confidence: 99%

“…MDR represents the most severe form of bacterial resistance. MDR tuberculosis is, therefore, a significant problem for tuberculosis control in many countries [2,8,10,11,15].…”

Section: Defining the Antituberculotic Resistant Casesmentioning

confidence: 99%