The impact of replacement therapy on dental health in haemophilia

Kozma, Andrei; Clevet, O.; Traila, Adina; Ursu, Emilia; Jinca, C.; Oancea, Roxana; Boeriu, Estera; Boia, Eugen Sorin; Ritli, L.; Şerban, M.; Lackner, AK; Lăzărescu, Horia; Popovici, Cătălin-George; Diac, I; Stănescu, Ama; Enachescu, C.; Arghirescu, Smaranda

doi:10.4323/rjlm.2019.200

Cited by 1 publication

(11 citation statements)

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“…Pakistan [12], India [6,10,14,[32][33][34], Northern Ireland [9], Brazil [15,[35][36][37], Uruguay [18], Romania [13],…”

Section: Studies Characteristicsmentioning

confidence: 99%

“…Sixteen studies involved individuals with hemophilia from hospitals or centers specialized in hematological treatment [4,6,7,9,12,14,[18][19][20]30,31,[33][34][35][36]38]. Four studies with hemophiliacs from university clinics [10,15,17,32]; two studies that used national records of hemophiliacs [11,22]; two studies did not report such information [13,16,19,21,39]. Two studies showed results from the same sample [11,22].…”

Section: Studies Characteristicsmentioning

confidence: 99%

“…Two studies used national hemophiliac's registers [11,22]. No recruitment data have been reported in three studies [13,19,39].…”

Section: Studies Characteristicsmentioning

confidence: 99%

“…All studies included evaluated dental caries experience through clinical examination. Sixteen studies endorsed the condition of oral hygiene/dental plaque [4,6,7,10,[13][14][15][16][19][20][21][22]31,32,34,39]. Twelve studies have evaluated the gingival condition [4,6,7,15,[17][18][19][20]32,35,38,39].…”

Section: Studies Characteristicsmentioning

confidence: 99%

“…The literature presents conflicting data about oral health conditions in hemophiliac patients. For example, some studies indicate that hemophiliacs have a lower prevalence of dental caries [9][10][11] than individuals without hemophilia, while other authors found no association [4,[12][13][14][15][16] or found a positive association [6,7,17] between dental caries and hemophilia. Similar contradictions are found for other oral conditions, such as oral hygiene patterns or periodontal disease [4,6,7,10,[13][14][15][16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

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Can Hemophilia Impact on the Oral Health Conditions of Children and Adolescents? A Systematic Review and Metanalysis

Silva

Souza

Wambier

et al. 2022

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective:To analyze if the oral health conditions in children and adolescents are associated with hemophilia (PROSPERO-42020168192). Material and Methods: The search strategy was performed in PubMed, Scopus, Lilacs/BBO, Web of Science, Cochrane, and Grey literature databases. Two independent researchers assessed the risk of bias in these studies by the Newcastle-Ottawa Scale. For the meta-analysis, the clinical conditions data were extracted as numerical variables according to their indexes, such as dental caries experience (dmft/DMFT), gingival condition (Modified Gingival Index -IGM), and oral hygiene (Plaque Index -PI). The quality of the evidence of the meta-analysis was evaluated by the GRADE tool (GRADEproGDT). Results: From a total of 431 studies, 27 were included, and 10 were included in the meta-analysis. The studies presented a moderate risk of bias, ranging from 2 to 7 points. The dental caries experience in primary (-0.62; CI95%: -1.68-0.43) and permanent dentitions (-0.05; CI95%: -0.69-0.59), gingival condition (-0.12; CI95%: -0.27-0.03), and oral hygiene (0.36; CI95%: -0.06-0.77) did not differ between the groups. Conclusion: Based on studies with very weak evidence, there were no differences in the oral health conditions of children and adolescents with and without hemophilia.

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