The impact of Ramadan fasting on glucose variability in type 2 diabetes mellitus patients on oral anti diabetic agents

Harbuwono, Dante Saksono; Kurniawan, Farid; Sudarsono, Nani Cahyani; Tahapary, Dicky L.

doi:10.1371/journal.pone.0234443

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…In our study, in concordance with previous studies [8,15], we did not find an increased incidence of hypoglycemia or hyperglycemia event during Ramadan fasting (data not shown). The inclusion of only low to moderate risk diabetic patients in our and previous studies might be the reason for this finding.…”

Section: Discussionsupporting

confidence: 94%

“…This study was part of The Diabetes and Ramadan Study Project 2019 held by the Division of Endocrinology and Metabolism, Internal Medicine Department, FMUI, Jakarta, Indonesia. Detailed methods of the Ramadan study projects have been published elsewhere [ 15 ]. Ethics approval was obtained from the Health Research Ethics Committee of Faculty of Medicine, Universitas Indonesia as stated in letter no.…”

Section: Methodsmentioning

confidence: 99%

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The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus

Harbuwono

Sazli

Kurniawan

et al. 2021

Heliyon

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Background/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters. Results: Ramadan fasting reduced Fetuin-A levels [median (minimum-maximum), 5.35 (2.91-7.81) vs. 3.22 (2.35-5.60) mg/dl; p ¼ 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan. Conclusion: Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan.

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Section: Discussionsupporting

confidence: 94%

Section: Methodsmentioning

confidence: 99%

The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus

Harbuwono

Sazli

Kurniawan

et al. 2021

Heliyon

Self Cite

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“…Pharmacological therapies during Ramadan generated the most interest over the last year, with several new studies evaluating both oral and injectable diabetes therapies. [23][24][25][26][27][28][29][30][31] The studies included evaluations of individual drugs, targets, and professionals' perceptions [Table 2].…”

Section: Pharmacological Management Of Diabetes During Ramadanmentioning

confidence: 99%

Ramadan fasting and diabetes (2020): The year in review

Hafidh

Ali

Abbas

et al. 2021

Journal of Diabetes and Endocrine Practice

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Review Article introduCtionRamadan fasting (RF) observed by adult Muslims entails abstinence from food, water, all oral substances, intravenous fluid therapy, and smoking between dawn and sunset during the 9 th month of the Muslims' lunar calendar. [1] Ramadan's impact on health and disease stems from the biological effects of prolonged fasting during the daytime and possible overfeeding at night and its various social changes. The last three decades witnessed a rising interest in the research on RF in health and disease. [2] Diabetes has been the most extensively studied single medical condition in connection with RF. [3] Despite the increase in volume of the literature, concern has been voiced regarding the quality of publications on the subject. [4,5] The literature on health aspects of Ramadan fasting (RF) is widely spread in many journals, making it not readily accessible to those interested in the subject. We therefore aimed to provide a thematic overview of the global research work conducted in the realm of RF during 2020 on the impact of RF in people with diabetes. We aimed to provide a concise bird's eye view of the literature published in a year and to identify the basis of evidence that may guide clinical practices for the years to come. matErials and mEthodsThis is a narrative, nonsystematic review of the literature retrieved from one online database over a full calendar year (2020). The PubMed search engine of the National Center for Biotechnology Information at the U.S. National Library of Medicine was used. The search term ("Ramadan Fasting" OR "Fast of Ramadan") AND diabetes, with time filters from January 1, 2020, to December 31, 2020, was used to identify the relevant records. Retrieved articles were examined forThe literature on health aspects of Ramadan fasting (RF) is widely spread in many journals, making it not readily accessible to those interested in the subject. We aimed to provide a narrative overview of the global literature production in 1 year (2020) on diabetes and RF. This was a narrative, nonsystematic review of the international literature from a single major medical online database (i.e., PubMed) during the year 2020. The search term "Ramadan fasting AND Diabetes" was used, and the relevant literature was narrated in a concise thematic account. The publications spanned a vast array of topics related to RF, including assessments of safety and efficacy profiles of older and newer diabetes therapies, modes of insulin delivery, evaluating the role of utilizing advanced technology for the treatment, and monitoring of blood glucose during RF. Increased interest was evident in capturing patients' perspectives and healthcare professionals' perceptions, attitudes, and practices during Ramadan. Fasting by high-risk groups was studied. Not surprisingly, some reports covered COVID-19 and Ramadan and the role of telemedicine in ramadan. The current literature review presents this year's research data on the safety of fasting practices, care models, and patients' experiences and perspectives....

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“… 8 Recently, Harbuwono et al, evaluated glucose variability in subjects with type 2 diabetes on oral antidiabetic agents using continuous glucose monitoring system (CGMS) during and after ramadan fasting. 19 In our study, it is noted that glucose monitoring and home readings were lower and were under normal range during ramadan when compared to the readings before ramadan in all pregnant women with diabetes. This may be due to the short-term improvement in the glycemic control.…”

Section: Discussionmentioning

confidence: 45%

Fructosamine as an Index of Short-Term Glycemic Control in Pregnant Women with Diabetes: Before, During and After Ramadan

Ekhzaimy¹,

Alkatari²,

Al-Maatouq³

et al. 2022

IJWH

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Purpose Impact of ramadan fasting on healthy and women with diabetes is already known. However, there is a scarcity of data on impact of fasting on pregnant women with diabetes. Moreover, religious and medical recommendations advise pregnant women against fasting as it is unsafe. Despite being exempted, many pregnant Muslim women with diabetes still choose to fast during ramadan. This study investigated different glycemic marker as an indicator for diabetes control in fasting pregnant women. Patients and Methods This is a prospective observational study. A total of 89 pregnant diabetes women were recruited. Blood glucose was self-monitored in all the pregnant women using glucose monitoring device at home. We measure the fructosamine, HbA1c levels before, during and after ramadan. Results Pregnant women with type 1 diabetes were 14 (25%), type 2 diabetes were 21 (37.5%), and gestational diabetes were 21 (37.5%). The mean fructosamine level decreased during and after ramadan in gestation diabetes pregnant women compared to type 2 diabetes and type 1 diabetes pregnant women subjects (p = 0.009). Conclusion The present study indicates that pregnant women with diabetes were able to fast during ramadan and there fructosamine level reduced during fasting. Utilization of fructosamine for short-term monitoring of glycemic control in addition to home glucose monitoring in pregnant women with diabetes will provide a good index of glycemic control. Recommendation Religious and medical recommendations advise pregnant women against fasting as it is unsafe, and they are under high risk. However, if they insist to do fast, they must do under strict medical supervision and fructosamine can be used as a glycemic control marker.

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The impact of Ramadan fasting on glucose variability in type 2 diabetes mellitus patients on oral anti diabetic agents

Cited by 7 publications

References 30 publications

The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus

The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus

Ramadan fasting and diabetes (2020): The year in review

Fructosamine as an Index of Short-Term Glycemic Control in Pregnant Women with Diabetes: Before, During and After Ramadan

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