The impact of “Ramadan fasting period” on total and differential white blood cells, haematological indices, inflammatory biomarker, respiratory symptoms and pulmonary function tests of healthy and asthmatic patients

Askari, Vahid Reza; Alavinezhad, Azam; Boskabady, Mohammad Hossein

doi:10.1016/j.aller.2015.10.002

Cited by 24 publications

(70 citation statements)

References 18 publications

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“…Thus far, to the best of our knowledge, there has been only 1 study related to this subject: the effects of Ramadan fasting on different features in asthmatic patients in a Muslim population. 78 The study shows that a 1-month Ramadan fasting period has no negative effect on asthma and might have some positive effect on asthma severity with regard to reduction of serum C-reactive protein concentrations and chest wheeze. The findings might be related to a recent study showing that serum IL-5 levels and blood eosinophil counts show circadian rhythms in mice and that mice fasted for 16 hours exhibit suppressed serum IL-5 and blood eosinophils.…”

Section: Future Directionsmentioning

confidence: 79%

Clockwork allergy: How the circadian clock underpins allergic reactions

Nakao

2018

Journal of Allergy and Clinical Immunology

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Allergic disease is characterized by marked day-night changes in the clinical symptoms and laboratory parameters of allergy. Recent reports suggest that the circadian clock, which drives a biological rhythm with a periodicity of approximately 24 hours in behavior and physiology, underpins a time of day-dependent variation in allergic reactions. New studies also suggest that disruption of clock activity not only influences temporal variation but can also enhance the severity of allergic reactions and even increase susceptibility to allergic disease. These findings suggest that the circadian clock is a potent regulator of allergic reactions that plays more than a simple circadian timekeeping role in allergy. A better understanding of these processes will provide new insight into previously unknown aspects of the biology of allergies and can lead to the application of clock modifiers to treat allergic disease. Finally, this area of research provides a novel opportunity to consider how modern lifestyles in the developed world are changing the clinical manifestations of allergy as our society quickly transforms into a circadian rhythm-disrupted society in which sleeping, working, and eating habits are out of sync with endogenous circadian rhythmicity. Such findings might reveal lifestyle interventions that enable us to better control allergic disease.

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Section: Future Directionsmentioning

confidence: 79%

Clockwork allergy: How the circadian clock underpins allergic reactions

Nakao

2018

Journal of Allergy and Clinical Immunology

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“…Based on the Global Initiative for Asthma (GINA) report, the number of people who are suffering from asthma is increasing yearly and more than 300 million. Given the nature of this disease, the patients experience complex respiratory inflammation, tracheal hyper‐responsiveness, obstruction and remodeling of the airways (Askari, Alavinezhad, & Boskabady, ; Boskabady, Hashemzehi, Khazdair, & Askari, ; Hashemzehi, Khazdair, Kiyanmehr, Askari, & Boskabady, ; Mashhadi, Askari, Ghorani, Jelodar, & Boskabady, ).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, pomegranate and EA may provide anticancer activity via enhancing the apoptotic protein related pathways including Bax, p53, cyt-c, caspase 3, caspase 9, caspase 8, Nrf2, GSK-3β, PARP cleavage, and Bax/Bcl-2 ratio, which induce cell cytotoxicity, and G1 and S-phases cell cycle arrest. There are many studies shown that pomegranate and EA are able to exert their anti-cancer effects by decreasing the levels of cell proliferation, β-catenin, JAK2, STAT3, MAPK, PKB, PI 3 K, Cyclin D1, MMP (Abbasi et al, 2017;Askari, Alavinezhad, & Boskabady, 2016;Askari, Baradaran Rahimi, et al, 2018a), NF-κB, COX-2, Bcl-2, and mTOR signaling pathways. All together, we wish to this review benefits the researchers for designing and evaluating the potential protective effects and utilization in the future further studies.…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation is commonly characterized as a defensive and protective reaction of the body against various exogenous or endogenous stimuli, which aims to maintain the body health. On the other hand, chronic inflammation may cause inflammatory disorders and pain through the secretion of inflammatory mediators including prostaglandins, nitric oxide (NO), interferon gamma (IFN‐γ) and histamine (Askari et al, ; Askari, Alavinezhad, & Boskabady, ; Askari, Baradaran Rahimi, Rezaee, & Boskabady, ; Askari, Rezaee, Abnous, Iranshahi, & Boskabady, ; Askari & Shafiee‐Nick, ; Rahimi et al, ; Rahimi et al, ; Rahimi, Askari, & Mousavi, ).…”

Section: Introductionmentioning

confidence: 99%

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Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

Rahimi

Ghadiri

Ramezani

et al. 2020

Phytotherapy Research

106

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Inflammation is commonly characterized as a defensive and protective reaction of the body to various exogenous or endogenous stimuli, which aims to maintain the body health. Punica granatum (pomegranate) and its constituent ellagic acid (EA) are recently more taken into accounts since their promising pharmacological effects. Therefore, we aimed to obtain a comprehensive review regarding antiinflammatory, anticancer, and antioxidant activities of both pomegranate and EA and their possible involved mechanisms. In the procedure, scientific databases, including Web of Science, PubMed, Scopus, and Google Scholar, were searched in the English language, until the end of January 2019. Pomegranate belonging to the Punicaceae has been used for medical purposes from ancient and in different cultures. Several studies have also supported that EA is the major active compound of pomegranate and possesses antimutagenic, antiinflammatory, antifibrosis, anticancer, and antiaging properties. It has been suggested that pomegranate and EA possess promising immunomodulatory effects in preclinical models as well as human studies through regulation of the T‐cell function and suppressing humoral immunity. Hopefully, we wish that this review and information could be helpful for designing further experiments to investigate the potential protective effects of pomegranate and EA.

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“…To the best of our knowledge, no study was previously conducted on the effect of Ramadan fasting on SIRT1 gene expression or protein function, although a few studies are reported investigating the effect of Ramadan fasting on inflammation and immune responses. For instance, Askari et al showed that serum high-sensitive CRP level significantly reduced after Ramadan fasting in control and asthmatic patients (11). However, many studies highlighted the correlation between caloric restriction, SIRT1 expression, and immune responses (6,7).…”

Section: Discussionmentioning

confidence: 99%

The Impact of Ramadan Fasting on SIRT1 mRNA Expression in Peripheral Blood Mononuclear Cells

2016

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Background: The aim of this study was to evaluate the effect of Ramadan fasting on SIRT1 mRNA expression in healthy men. Islamic Ramadan fasting is a holy religious ceremony that has many spiritual benefits. Additionally, it can be considered as the equivalent of calorie restriction that may affect physical health. The results of previous studies revealed that calorie restriction increases the lifespan in laboratory rodents via increasing the expression of a histone deacetylase named SIRT1. Additionally, SIRT1 is known for its anti-inflammatory properties. Materials and Methods: Overall, 43 men volunteered for participating in this one-group before and after (self-controlled) study. Two mL blood samples were taken prior to fasting and at the end of the 30 th day of fasting. Routine biochemical tests and SIRT1 mRNA expression analysis were performed. Results: Cholesterol and low-density lipoproteins increase, however, high-density lipoproteins level decreased after Ramadan fasting. The analysis of real-time PCR results revealed that SIRT1 mRNA expression in human peripheral blood mononuclear cells increased 4.63 fold in fasting state in comparison with nonfasting state. Conclusion: Ramadan fasting has a significant effect on SIRT1 gene expression. Considering the immunosuppressive and anti-inflammatory properties of SIRT1, further studies are needed to evaluate the effects of SIRT1 up-regulation on the autoimmune and inflammatory diseases during Ramadan fasting.

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The impact of “Ramadan fasting period” on total and differential white blood cells, haematological indices, inflammatory biomarker, respiratory symptoms and pulmonary function tests of healthy and asthmatic patients

Abstract: These results show that Ramadan fasting period has no negative impact on asthma and may have some positive effect on asthma severity with regard to reduction of hs-CRP concentration and chest wheeze.

Cited by 24 publications

References 18 publications

Clockwork allergy: How the circadian clock underpins allergic reactions

Clockwork allergy: How the circadian clock underpins allergic reactions

Antiinflammatory and anti‐cancer activities of pomegranate and its constituent, ellagic acid: Evidence from cellular, animal, and clinical studies

The Impact of Ramadan Fasting on SIRT1 mRNA Expression in Peripheral Blood Mononuclear Cells

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