The impact of psychosocial stress and stress management on immune responses in patients with cancer

Antoni, Mike; Dhabhar, Firdaus S.

doi:10.1002/cncr.31943

Cited by 202 publications

(199 citation statements)

References 147 publications

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“…In the present study, about 92% of the WHCs were afraid of being infected with the disease and transmitting it to the family. Stress, as a hidden variable, indirectly weakens the immune system and increases the risk of disease [16]. Due to the novelty of the virus and its rapid epidemic, health care workers did not receive adequate training and awareness regarding the prevention and control of COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Knowledge, Attitude and Behavior of Health Care Workers in the Prevention of COVID-19

Maleki

Najafi

Farhadi

et al. 2020

Preprint

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Background Preserving the health of health care workers (HCWs) has now become one of the main concerns of all countries affected by the coronavirus. Maintaining the health of the hospital workers, especially the medical staff, requires knowledge and awareness, followed by proper behavior for disease prevention and transmission. The purpose of this study was to evaluate the knowledge, attitude and behavior of HCWs to ward patients with suspected or confirmed COVID-19.Methods A cross-sectional study was designed to assess the level of knowledge, attitude and behavior of 191 HCWs of Taleghani Hospital in Kermanshah toward patients with suspected or confirmed COVID-19. Responses to the checklists of demographic characteristics, knowledge, attitude, and behavior toward patients with COVID-19 were analyzed by SPSS 22.Results 191 subjects (118 females and 73 males) with a mean age of 34.7 ± 8.6 years participated in this study. The level of knowledge of HCWs in this study was excellent regarding the ways of transmitting the disease such as close contact with the patient with suspected Coronavirus (99%). According to their positions, participants had a significant difference in their knowledge of asymptomatic patients (P < 0.001). The study found that 14% of the HCWs did not have the necessary knowledge about the symptoms of COVID-19, indicating poor knowledge of the HCWs at the beginning of the disease epidemic. The results obtained from the evaluation of HCWs attitudes showed that some workers believed that protective and preventive measures should only be applied when managing people with severe symptoms (P < 0.001). Finally, there was a significant difference in behavior and adherence to protective and preventive measures between the participants when facing patients with severe symptoms and without symptoms of COVID-19 (P = 0.05).Conclusion Knowledge, attitude, and behavior toward COVID-19 infection and facing patients with severe and overt symptoms among health care workers in the hospital were Excellent, but these were insufficient for patients without obvious symptoms. These results suggest that additional training regarding subclinical cases of Coronavirus is needed for HCWs to protect them from contamination and prevent disease transmission to their colleagues and other patients as well.

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Section: Discussionmentioning

confidence: 99%

Knowledge, Attitude and Behavior of Health Care Workers in the Prevention of COVID-19

Maleki

Najafi

Farhadi

et al. 2020

Preprint

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“…Another important psychological variable that affects the health status of patients with cancer is stress, anxiety, and depression (Antoni & Dhabhar, 2019; Shohani, Mozafari, Sayehmiria, & Amoozadeh, 2018; Tabriz, Mohammadi, Roshandel, & Talebi, 2019). Although caregivers have a great deal of involvement in helping and caring for the patient, their training in psychological support/stress management is often very limited as is their access to resources (Rha, Park, Song, Lee, & Lee, 2015; Salmani, Ashketorab, & Hasanvand, 2014).…”

Section: Introductionmentioning

confidence: 99%

Investigating psychological problems in caregiver of pediatrics with cancer: A systematic review

Shokri

Tarjoman

Borji

et al. 2020

Child Adoles Psych Nursing

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Purpose Cancer is a type of chronic illness that causes many issues for patients and their caregivers, including a wide range of psychological problems. This study was conducted to determine the status and psychological problems of caregivers of pediatric patients with cancer who live in Iran. Methods All articles from 2000 to March 2019 related to the psychological of caregivers and their child's cancer were included in the search. Domestic websites in Iran and international databases were searched. Keywords of the search included child, cancer, malignancy, care burden, stress, anxiety, depression, coping strategies, psychological hardiness, posttraumatic stress, parents, father, mother, and pediatric. The search, data extraction, quality assessment and screening were conducted independently by two researchers. Results In the initial search, 345 articles were extracted regarding the psychological problems of caregivers. After final screening 15 articles were selected; from these four referred to care burden, four articles for coping skills, three articles for posttraumatic stress disorder (PTSD) and four articles for stress, anxiety, and depression among carers of children with cancer. Conclusion Considering the existence of psychological problems such as caregiver burden, PTSD, stress, anxiety, and depression in caregivers of children with cancer, it is necessary to provide nursing interventions for this group of parents; particularly interventions that provide the necessary ground for reducing psychological problems and improving caregivers' mental health.

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“…In the current study, we examined brain metabolic activity in patients who had mBCa using 18 F‐FDG PET/CT imaging in several ROIs that had previously been associated with NA in healthy populations and in patients with nonmetastatic cancer. Patients with mBCa endure multiple stressors during treatment, 44 and individual differences in adaptation to these challenges are associated with distress and NA states, 45,46 adrenal stress hormone dysregulation, 47 inflammatory processes, 48,49 and poorer long‐term health outcomes 50,51 (for a review, see Antoni and Dhabhar 52 ). It is important to note that previous work relating brain activity to distress in patients who have cancer has been conducted in patients with early stage BCa.…”

Section: Discussionmentioning

confidence: 99%

Negative affect and stress‐related brain metabolism in patients with metastatic breast cancer

Reis

Travado

Antoni

et al. 2020

Cancer

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Background Cancer and its treatment represent major stressors requiring that patients make multiple adaptations. Despite evidence that poor adaptation to stressors is associated with more distress and negative affect (NA), neuroimmune dysregulation and poorer health outcomes, current understanding is very limited of how NA covaries with central nervous system changes to account for these associations. Methods NA was correlated with brain metabolic activity using 18F‐fluorodeoxyglucose positron emission tomography/computed tomography (18F‐FDG PET/CT) in several regions of interest in 61 women with metastatic breast cancer. Patients underwent 18F‐FDG PET/CT and completed an assessment of NA using the Brief Symptom Inventory. Results Regression analyses revealed that NA was significantly negatively correlated with the standardized uptake value ratio of the insula, thalamus, hypothalamus, ventromedial prefrontal cortex, and lateral prefrontal cortex. Voxel‐wise correlation analyses within these 5 regions of interest demonstrated high left‐right symmetry and the highest NA correlations with the anterior insula, thalamus (medial and ventral portion), lateral prefrontal cortex (right Brodmann area 9 [BA9], left BA45, and right and left BA10 and BA8), and ventromedial prefrontal cortex (bilateral BA11). Conclusions The regions of interest most strongly negatively associated with NA represent key areas for successful adaptation to stressors and may be particularly relevant in patients with metastatic breast cancer who are dealing with multiple challenges of cancer and its treatment.

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The impact of psychosocial stress and stress management on immune responses in patients with cancer

Cited by 202 publications

References 147 publications

Knowledge, Attitude and Behavior of Health Care Workers in the Prevention of COVID-19

Knowledge, Attitude and Behavior of Health Care Workers in the Prevention of COVID-19

Investigating psychological problems in caregiver of pediatrics with cancer: A systematic review

Negative affect and stress‐related brain metabolism in patients with metastatic breast cancer

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