The Impact of Psychological Distress on Cervical Cancer

Wu, Chen‐Ta; Chiu, Lu-Ting

doi:10.3390/cancers15041100

Cited by 6 publications

(5 citation statements)

References 40 publications

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“…The observed causal relationship between mood swing and endometrial cancer is consistent with existing evidence highlighting the potential role of psychological factors in the development of gynecological disorders [14]. Psychological distress and mood disturbances have been associated with hormonal imbalances and alterations in immune function, which might in uence cancer risk [24][25][26].…”

Section: Discussionsupporting

confidence: 82%

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Causal relationship between mood swing and gynecological disorders: a Mendelian randomization study

Bian,

Li,

Shang

et al. 2023

Preprint

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Background Increasing number of observational studies have associated mood instability to common female diseases, but the underlying causal relationship remains unclear. In this work, Mendelian randomization (MR) analysis was applied to explore the genetically predicted causal relationship of mood swings and several prevalent gynecological disorders. Methods Instrumental variables (IVs) of mood swings were selected from UK Biobank (UKB), with 204,412 cases and 247,207 controls being incorporated. The genetic variants for female disorders were obtained from genome-wide association studies (GWASs) and FinnGen consortium. To avoid biases caused by racial difference, only European population was included here. Five strong analytical methodologies were used to increase the validity of the results, the most substantial of which was the inverse variance weighting (IVW) method. Pleiotropy, sensitivity, and heterogeneity were assessed to strengthen the findings. Results We found mood swings was significantly positively associated with risk of endometrial cancer (OR = 2.60 [95%CI = 1.36, 4.95], P = 0.0037), cervical cancer (OR = 1.01[95%CI = 1.00,1.02], P = 0.0213) and endometriosis (OR = 2.58 [95%CI = 1.18, 5.60], P = 0.0170) by IVW method. However, there was no causal relationship between mood swing and ovarian cancer. No pleiotropy and heterogeneity existed and sensitivity tests were passed. Conclusion This study reveals genetically predicted causal relationships between mood swing and the risk of endometrial cancer, cervical cancer and endometriosis in European populations through MR analysis, which makes up for observational research's inherent limitations.

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Section: Discussionsupporting

confidence: 82%

“…Evidence suggests that mood swings may in uence the risk of certain gynecological disorders [14]. Endometrial cancer, cervical cancer, ovarian cancer, and endometriosis are among the conditions that have been investigated in this context.…”

Section: Introductionmentioning

confidence: 99%

Causal relationship between mood swing and gynecological disorders: a Mendelian randomization study

Bian,

Li,

Shang

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…At the same time, researchers consider that the suppressive effects of chronic stress and increased levels of cortisol on cell‐mediated immune responses may result in promoting high risk HPV persistence and progression, which consequently can cause cervical dysplasia 12 and cancer 13 . From this perspective, the finding of our study highlights the need for future cervical health control for preventing the possible long‐term consequences of war‐related stress on cervical pathology.…”

Section: Discussionmentioning

confidence: 62%

The detrimental consequences of two consecutive disasters impacting cytopathology in Ukraine: COVID followed by the war

et al. 2023

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The Covid‐19 pandemic and ongoing war in Ukraine caused unprecedented disruption in healthcare, including cytopathology activities. This paper elucidates the effect of two consecutive disasters—the COVID‐19 pandemic followed by the war—on cytopathology practice in Ukraine through a single‐centre retrospective study. Total testing volumes, geographic distribution, and indicators of laboratory operations were assessed during three periods of 3 months each: the first 3 months of the acute phase of the war (March‐May 2022, period 1); summer (June‐August 2022, period 2); and the fall (September‐November 2022, period 3, associated with massive attacks on the energy infrastructure in Ukraine). These data were compared with the corresponding periods in 2020, during the COVID‐19 pandemic, and in 2021, the post‐lockdown period. The ongoing war in Ukraine has caused a dramatic disruption in routine health maintenance and cytological practice. A net decline in both PAP testing and non‐gynaecological pathology was associated with a geographic redistribution of cytopathological testing, and an increase in the rate of abnormal sample reporting. Despite these challenges, cytopathology practice in Ukraine demonstrates resilience, allowing for maintaining the healthcare system and addressing the needs of the civil population during the war. The ongoing war in Ukraine heavily affected cytological practice. The decline in PAP testing during the early period of the war was associated with an increase in the abnormal sample rate. Further study of the war's impact on the cervical pathology rate and the health of the population in the next decades is needed.

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“…Mood disorders, such as depression and bipolar disorder, are found to be linked to a higher likelihood of developing cervical cancer. This association is particularly evident among individuals aged 30-50 years and those with white-collar jobs [9,10].…”

Section: Introductionmentioning

confidence: 99%

Experiences of Women Living with Cervical Cancer: A Study in the Tamale Metropolis

Musa,

Boateng

2024

AJMAH

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Background: Cervical cancer cases are increasing globally, including in Ghana. Nevertheless, despite the increasing prevalence of this ailment among women, there has been a dearth of extensive research conducted on the subject. Research conducted in several countries has shown that individuals who have survived cervical cancer face numerous difficulties, including socioeconomic, medical, and psychological issues. This study aims to investigate the experiences of women in this particular group, with a focus on the psychological, socio-economic, and hurdles encountered when seeking care. Methodology: The study employed an exploratory descriptive qualitative design. The research was carried out in the Tamale Metropolis, with a specific focus on women who have received a diagnosis of the condition and are now receiving treatment at the Tamale Teaching Hospital. Participants for the study were recruited using purposive sampling. Participants were interviewed face-to-face using a semi-structured interview guide. The interviews recorded on tape were transcribed exactly as spoken and subsequently evaluated manually using the content analysis method. Thematic analysis was employed to analyse the results. Findings: The results indicate that women residing in the Tamale Metropolis who have cervical cancer encounter a disturbance in their social lives, as shown by their unsatisfactory interactions with others. While certain close relatives, acquaintances, and colleagues offer support, others are left behind at times of necessity. Recommendations: Policymakers and the government should implement measures to cover the expenses associated with cervical cancer treatment, similar to how it is done for other diseases through the NHIS. Women diagnosed with cervical cancer should undergo counseling to alleviate the psychological distress they experience.

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The Impact of Psychological Distress on Cervical Cancer

Cited by 6 publications

References 40 publications

Causal relationship between mood swing and gynecological disorders: a Mendelian randomization study

Causal relationship between mood swing and gynecological disorders: a Mendelian randomization study

The detrimental consequences of two consecutive disasters impacting cytopathology in Ukraine: COVID followed by the war

Experiences of Women Living with Cervical Cancer: A Study in the Tamale Metropolis

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