The impact of probiotics, prebiotics, and synbiotics on the biochemical, clinical, and immunological markers, as well as on the gut microbiota of obese hosts

Silva, Tatiane Ferreira da; Casarotti, Sabrina Neves; Oliveira, Gislane Lelis Vilela de; Penna, Ana Lúcia Barretto

doi:10.1080/10408398.2020.1733483

Cited by 73 publications

(55 citation statements)

References 105 publications

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“…Studies tend to argue for the superior ability to stimulate IgA immunoglobulin synthesis of probiotic supplement formulas, especially when they are combined with prebiotics. In addition to supporting the synthesis of type A immunoglobulins, probiotics have also been shown to modulate the inflammatory processes and activity of natural killer NK cells, which fight virally infected and cancerous cells [ 164 ]. Moreover, probiotics increase the efficiency of the barrier function represented by the intestinal mucosa, therefore reducing the permeability induced by pathogenic microorganisms, but also that associated with inflammation [ 165 ].…”

Section: Discussionmentioning

confidence: 99%

Probiotics: Versatile Bioactive Components in Promoting Human Health

et al. 2020

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The positive impact of probiotic strains on human health has become more evident than ever before. Often delivered through food, dietary products, supplements, and drugs, different legislations for safety and efficacy issues have been prepared. Furthermore, regulatory agencies have addressed various approaches toward these products, whether they authorize claims mentioning a disease’s diagnosis, prevention, or treatment. Due to the diversity of bacteria and yeast strains, strict approaches have been designed to assess for side effects and post-market surveillance. One of the most essential delivery systems of probiotics is within food, due to the great beneficial health effects of this system compared to pharmaceutical products and also due to the increasing importance of food and nutrition. Modern lifestyle or various diseases lead to an imbalance of the intestinal flora. Nonetheless, as the amount of probiotic use needs accurate calculations, different factors should also be taken into consideration. One of the novelties of this review is the presentation of the beneficial effects of the administration of probiotics as a potential adjuvant therapy in COVID-19. Thus, this paper provides an integrative overview of different aspects of probiotics, from human health care applications to safety, quality, and control.

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Section: Discussionmentioning

confidence: 99%

Probiotics: Versatile Bioactive Components in Promoting Human Health

et al. 2020

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“…In addition, increasing attention is now given to prebiotics, probiotics, and symbiotics [ 166 ]. Prebiotics are nondigestible substances contained in aliments, as well as water-soluble fibers, including beta-glucans, oligosaccharides, and soy oligosaccharides.…”

Section: Mediterranean Diet Inflammaging and Ckd/rrt Patientsmentioning

confidence: 99%

Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies

et al. 2021

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Access to renal transplantation guarantees a substantial improvement in the clinical condition and quality of life (QoL) for end-stage renal disease (ESRD) patients. In recent years, a greater number of older patients starting renal replacement therapies (RRT) have shown the long-term impact of conservative therapies for advanced CKD and the consequences of the uremic milieu, with a frail clinical condition that impacts not only their survival but also limits their access to transplantation. This process, referred to as “inflammaging,” might be reversible with a tailored approach, such as RRT accompanied by specific nutritional support. In this review, we summarize the evidence demonstrating the presence of several proinflammatory substances in the Western diet (WD) and the positive effect of unprocessed food consumption and increased fruit and vegetable intake, suggesting a new approach to reduce inflammaging with the improvement of ESRD clinical status. We conclude that the Mediterranean diet (MD), because of its modulative effects on microbiota and its anti-inflammaging properties, may be a cornerstone in a more precise nutritional support for patients on the waiting list for kidney transplantation.

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“…These changes are closely connected with the composition of gut microbiome. Table 4 summarizes the effects of different metabolic changes during pregnancy on gut microbiome (Collado et al, 2008;Santacruz et al, 2010;Gohir et al, 2015;Kuang et al, 2017;Crusell et al, 2018).…”

Section: Factors Affecting Gut Microbiome During Pregnancymentioning

confidence: 99%

“…In addition to lactation, there are also significant differences in the composition of gut microbiome in postpartum women. Operational taxonomic units richness and Shannon index decreased from late pregnancy to postpartum regardless of metabolic status (Crusell et al, 2018;Hasan et al, 2018). However, it lack of evidence to demonstrate the difference between breastfeeding and non-breastfeeding women, and further researches are needed.…”

Section: Alterations Of Gut Microbiome During Lactationmentioning

confidence: 99%

“…Prebiotics is an indigestible food ingredient that selectively stimulates the growth and activity of probiotics in the intestine, thereby improving host health (Naseer et al, 2020;Ricke et al, 2020). It is currently defined as "a substrate that is selectively utilized by host microorganisms endowed with health benefits," and its "selectivity" mainly refers to Lactobacillus and Bifidobacterium (da Silva et al, 2020). Oral prebiotics supplements, especially those added with plant polysaccharides, are effective to improve gut microbiome (Roberfroid et al, 2010).…”

Section: Prebiotics or Probiotics Supplementationmentioning

confidence: 99%

See 1 more Smart Citation

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation

Yao¹,

Cai²,

Fei³

et al. 2020

Front. Pharmacol.

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial inflammation and bone destruction. Microbial infection is considered to be the most important inducement of RA. The pregnancy planning of women in childbearing age is seriously affected by the disease activity of RA. Gut microbiome, related to immunity and inflammatory response of the host. At present, emerging evidence suggested there are significant differences in the diversity and abundance of gut microbiome during pregnancy and lactation, which may be associated with the fluctuation of RA disease activity. Based on these research foundations, we pioneer the idea of regulating gut microbiome for the treatment of RA during pregnancy and lactation. In this review, we mainly introduce the potential treatment strategies for controlling the disease activity of RA based on gut microbiome during pregnancy and lactation. Besides, we also briefly generalize the effects of conventional anti-rheumatic drugs on gut microbiome, the effects of metabolic changes during pregnancy on gut microbiome, alteration of gut microbiome during pregnancy and lactation, and the effects of anti-rheumatic drugs commonly used during pregnancy and lactation on gut microbiome. These will provide a clear knowledge framework for researchers in immune-related diseases during pregnancy. Regulating gut microbiome may be a potential and effective treatment to control the disease activity of RA during pregnancy and lactation.

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The impact of probiotics, prebiotics, and synbiotics on the biochemical, clinical, and immunological markers, as well as on the gut microbiota of obese hosts

Cited by 73 publications

References 105 publications

Probiotics: Versatile Bioactive Components in Promoting Human Health

Probiotics: Versatile Bioactive Components in Promoting Human Health

Nutrition-Based Management of Inflammaging in CKD and Renal Replacement Therapies

Regulating Gut Microbiome: Therapeutic Strategy for Rheumatoid Arthritis During Pregnancy and Lactation

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