The impact of preoperative micronutrient supplementation in lung surgery. A prospective randomized trial of oral supplementation of combined α-ketoglutaric acid and 5-hydroxymethylfurfural

Abstract

Simple oral supplementation using a combination of alpha-KG and 5-HMF of preoperative micronutrition may therefore be one further step in a multimodality approach of fast-track surgery programs also in lung surgery.

Elevated CO2 Levels Cause Mitochondrial Dysfunction and Impair Cell Proliferation

“…We found that the addition of ␣KG rescued the negative effect of high levels of CO 2 on cell proliferation. This is in agreement with the suggestion of ␣KG as a potential pharmacological agent to improve some mitochondrial pathological disorders such as those with ATP synthase deficiency (45) and in patients undergoing lung resection to decrease oxidative stress (46).…”

Efficient production of α-ketoglutarate in the gdh deleted Corynebacterium glutamicum by novel double-phase pH and biotin control strategy

“…As the precursor of various amino acids and heterocyclic compounds [1,2], a-KG is used as a building block for synthesizing numerous important products, e.g. pharmaceutical agents, food additives and biomaterials.…”

Effects of Antioxidant Supplementation on Exercise Performance in Acute Normobaric Hypoxia

“…When such effects could be confirmed after prolonged antioxidants supplementation, athletes or mountaineers would greatly benefit during acute altitude exposure. Matzi et al (2007) for instance demonstrated that the combined oral intake of α-KG compounded with 5-hydroxymethylfurfural (5-HMF) improved exercise capacity and reduced oxidative stress after lung surgery. In addition, 5-HMF has been shown to elicit protective properties against hypoxic injury (Li et al, 2011a and b) and on the vascular endothelium as demonstrated in human umbilical vein endothelial cells (HUVECs; Cao et al, 2013;Kim et al, 2011).…”