2011
DOI: 10.1371/journal.pone.0023129
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The Impact of Preoperative Hip Heterotopic Ossification Extent on Recurrence in Patients with Head and Spinal Cord Injury: A Case Control Study

Abstract: BackgroundThe preoperative Heterotopic Ossification (HO) extent is usually one of the main used criteria to predict the recurrence before excision. Brooker et al built a radiologic scale to assess this pre operative extent around the hip. The aim of this study is to investigate the relationship between the recurrence risk after hip HO excision in Traumatic Brain Injury (TBI) and Spinal Cord Injury (SCI) patients and the preoperative extent of HO.Methodology/Principal FindingsA case control study including TBI … Show more

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Cited by 33 publications
(21 citation statements)
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“…Both hereditary and acquired HO are debilitating conditions that can lead to the atrophy of skin and soft tissue breakdown throughout the residual limb, severe pain, nerve entrapment and impaired joint movement. Current treatments are invasive (surgical removal) or non-specific (radiation therapy or non-steroidal anti-inflammatory drugs), with the likelihood of HO recurrence potentially reaching levels of 25% [6,8]. Therefore, the need to understand the complex pathological mechanisms underlying HO is of great importance if effective therapies are to be devised.…”
Section: Heterotopic Ossificationmentioning
confidence: 99%
“…Both hereditary and acquired HO are debilitating conditions that can lead to the atrophy of skin and soft tissue breakdown throughout the residual limb, severe pain, nerve entrapment and impaired joint movement. Current treatments are invasive (surgical removal) or non-specific (radiation therapy or non-steroidal anti-inflammatory drugs), with the likelihood of HO recurrence potentially reaching levels of 25% [6,8]. Therefore, the need to understand the complex pathological mechanisms underlying HO is of great importance if effective therapies are to be devised.…”
Section: Heterotopic Ossificationmentioning
confidence: 99%
“…Unfortunately, these treatment options have been unsuccessful in preventing or curing HO. Surgical excision has recurrence rates as high as 25 percent, requiring further surgery [3,[13][14]. Likewise, these treatments may cause additional morbidity and mortality to patients.…”
Section: Introductionmentioning
confidence: 99%
“…We carried out a case-control study using the BANKHO database. 28 No significant relationship was found between recurrence and the location around the joint or the Brooker status, even when all the matching factors were included in the analysis.…”
Section: Included Studiesmentioning
confidence: 87%
“…Recurrence was evaluated in the total sample (539 surgeries), 5 as well as in sub-groups comprising traumatic brain injury and SCI patients (95 interventions). 28 Does the extent of the HO affect the risk of recurrence of troublesome HO after CNS lesion? Historical approach.…”
Section: Included Studiesmentioning
confidence: 99%