The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast

Mann, Ritse M.; Loo, Claudette E.; Wobbes, Theo; Bult, Peter; Barentsz, Jelle O.; Gilhuijs, Kenneth G. A.; Boetes, C.

doi:10.1007/s10549-009-0616-6

Cited by 183 publications

(113 citation statements)

References 46 publications

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“…All ILC sites were detected on MRI, which is rarely the case of conventional mammograms or sonograms (3,25). Moreover, some studies (29,30) have suggested that the rate of local recurrences is higher in patients who undergo re-excision than in patients who are initially successfully treated, and our findings therefore imply that preoperative MRI could improve local control (12).…”

Section: Mri-pathological Correlationmentioning

confidence: 58%

“…Positive pathological margins after conservative surgery are more frequent in ILC than in IDC (8), leading to more frequent re-excision and local recurrence risk (12).…”

mentioning

confidence: 99%

“…Some authors have suggested that optimal pre-operative staging of ILC, including breast MRI, could improve patient outcome (12). MRI has been described as one of the most appropriate tools for ILC staging (3), because of its high sensitivity for ILC detection and staging (ranging from 95% (13) to 100% (14)) and its high negative predictive value (NPV) (ranging from 95% (13) to 100% (2,5,6,14)).…”

mentioning

confidence: 99%

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Invasive lobular carcinoma of the breast: MRI pathological correlation following bilateral total mastectomy

et al. 2012

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Section: Mri-pathological Correlationmentioning

confidence: 58%

“…Positive pathological margins after conservative surgery are more frequent in ILC than in IDC (8), leading to more frequent re-excision and local recurrence risk (12).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Invasive lobular carcinoma of the breast: MRI pathological correlation following bilateral total mastectomy

et al. 2012

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“…This preoperative tool reduces the need for re-excision after BCS 22,23 . However, a recent meta-analysis has demonstrated that preoperative MRI potentially increases the mastectomy ratio 24 .…”

Section: Discussionmentioning

confidence: 99%

Volume of breast tissue excised during breast-conserving surgery in patients undergoing preoperative systemic therapy

Valejo¹,

Tiezzi²,

Mandarano³

et al. 2013

Rev. Bras. Ginecol. Obstet.

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“…Given the theoretical benefit of MRI in preoperative planning, previous papers identified two main study end-points; the first was a shortterm benefit via reducing the re-excision rate [19][20][21][22][23][24][25][26] ; the second was long-term benefit resulting in improved disease recurrence rate and survival. 27 In view of disease recurrence and mortality being so rare in the modern era, most studies were unable to provide data on the second end-point.…”

Section: Discussionmentioning

confidence: 99%

Impact of magnetic resonance imaging on preoperative planning for breast cancer surgery

Law

Cheung²,

Lau³

et al. 2013

Hong Kong Med J

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ResultsThe most common indication for breast magnetic resonance imaging was the presence of multiple indeterminate shadows on ultrasound scans (53%), followed by ill-defined border of the main tumour on ultrasound scans (19%). In 66% (97 out of 147) of the patients, the extent of the operation was upgraded. Upgrading entailed: lumpectomy to wider lumpectomy (23 out of 97), lumpectomy to mastectomy (47 out of 97), lumpectomy to bilateral lumpectomy (15 out of 97), and other (12 out of 97). Mostly, these management changes were because magnetic resonance imaging showed more extensive disease (n=29), additional cancer foci (n=39), or contralateral disease (n=24). In five instances, upgrading was due to patient preference. In 34% (50 out of 147) of the patients, there was no change in the planned operation. Regarding 97 of the patients having altered management, in 12 the changes were considered inappropriately extensive (due to false-positive magnetic resonance imaging findings). In terms of magnetic resonance imaging detection of more extensive, multifocal, multicentric, or contralateral disease, the false-positive rate was 13% and false-negative rate 7%. Corresponding rates for sensitivity and specificity were 95% and 81%, using the final pathology as the gold standard.Conclusions Preoperative magnetic resonance imaging had a clinically significant and mostly correct impact on management plans. Magnetic resonance imaging should be included as part of the preoperative investigation in patients planned for breastconserving surgery, in whom there are doubts about the extent of the tumours based on conventional assessment. • MRI demonstrated high sensitivity and moderate specificity in detecting additional cancer foci. Impact of magnetic resonance imaging on preoperative planning for breast cancer surgery O R I G I N A L A R T I C L E Implications for clinical practice or policy• Preoperative MRI should be considered in patients with suspected additional disease foci or indeterminate tumour margins, in addition to conventional imaging by mammography and ultrasonography. CME # Preoperative planning for breast cancer surgery #

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The impact of preoperative breast MRI on the re-excision rate in invasive lobular carcinoma of the breast

Cited by 183 publications

References 46 publications

Invasive lobular carcinoma of the breast: MRI pathological correlation following bilateral total mastectomy

Invasive lobular carcinoma of the breast: MRI pathological correlation following bilateral total mastectomy

Volume of breast tissue excised during breast-conserving surgery in patients undergoing preoperative systemic therapy

Impact of magnetic resonance imaging on preoperative planning for breast cancer surgery

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