The Impact of Preexisting Myocardial Remodeling on Ventricular Function Early after Tetralogy of Fallot Repair

Farah, Maria Cecília Knoll; Castro, Claudia R. P.; Moreira, Valéria de Melo; Binotto, Maria Angélica; Guerra, Vitor; Riso, Arlindo de Almeida; Marcial, Miguel Barbero; Lopes, Antônio Augusto; Mathias, Wilson; Aiello, Vera Demarchi

doi:10.1016/j.echo.2010.06.008

Cited by 23 publications

(24 citation statements)

References 30 publications

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“…Two studies describing age-capacitance correlation were based on the biological material derived from young individuals [18, 19]. Both of them describe non-healthy children diagnosed with the tetralogy of Fallot, which is connected with right ventricular hypertrophy [20, 21]. As we were not able to find separate reports describing healthy young individuals, they were intentionally included in the healthy population.…”

Section: Methodsmentioning

confidence: 99%

Inter-individual Variability in the Pre-clinical Drug Cardiotoxic Safety Assessment—Analysis of the Age–Cardiomyocytes Electric Capacitance Dependence

Polak

Fijorek

2012

J. of Cardiovasc. Trans. Res.

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Electrical phenomena located within the plasma membrane of the mammalian cardiac cells are connected with the cells’ main physiological functions—signals processing and contractility. They were extensively studied and described mathematically in so-called Hodgkin–Huxley paradigm. One of the physiological parameters, namely cell electric capacitance, has not been analyzed in-depth. The aim of the study was to validate the mechanistic model describing the capacitive properties of cells, based on a collected experimental dataset which describes the electric capacitance of human ventricular myocytes. The gathered data was further utilized for developing an empirical correlation between a healthy individual’s age and cardiomyocyte electric capacitance.

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Section: Methodsmentioning

confidence: 99%

Inter-individual Variability in the Pre-clinical Drug Cardiotoxic Safety Assessment—Analysis of the Age–Cardiomyocytes Electric Capacitance Dependence

Polak

Fijorek

2012

J. of Cardiovasc. Trans. Res.

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“…Myocardial fibrosis presents one of the major challenges clinically not just to improve the survival rate and also the quality of life. Cardiac magnetic resonance (CMR) has been useful in measuring the extent of diffuse myocardial fibrosis, which is considered as a common pathological pathway that leads to the loss of myocardial function (4,5). Inasmuch as fibrosis can be reversible (6), its quantification using CMR can be useful in changing the way the cardiac fibrosis patients are monitored and treated (7).…”

Section: Introductionmentioning

confidence: 99%

“…Alterations in myocardial architecture associated with fibrotic remodeling lead to deranged heart function in different ways. Thus, in patients after tetralogy of Fallot repair, fibrous endocardial thickening of the right ventricular infundibulum is a predictor of poor right ventricular function (5). On the other hand, myocardial fibrosis is associated with systolic ventricular dysfunction early in life in patients with tricuspid atresia (11).…”

Section: Introductionmentioning

confidence: 99%

Myocardial fibrosis in congenital and pediatric heart disease

Tian

Niu

2017

Experimental and Therapeutic Medicine

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Cardiac fibrosis is a common phenomenon in different types of heart diseases, such as ischemic heart disease, inherited cardiomyopathy mutations, diabetes, and ageing and is associated with morbidity and mortality. Increased accumulation of extracellular matrix (ECM) that impacts cardiac function, is the underlying cause of fibrotic heart disease. There are four different types of cardiac fibrosis, including, reactive interstitial fibrosis, replacement fibrosis, infiltrative interstitial fibrosis and endomyocardial fibrosis. They are involved in the activation and transformation of cardiac fibroblasts to myofibroblasts, which participate in ECM production and fibrotic process and several inflammatory pathways. Besides the ECM proteins, myofibroblasts also express smooth muscle α-actin, SM22 and caldesmon and other markers related to fibrotic process. Most commonly employed techniques to assess myocardial fibrosis include stress echocardiography, cardiac magnetic resonance imaging and positron emission tomography. Because of the involvement of renin-angiotensin-II-aldosterone system, transforming growth factor-β signaling and activin-linked kinase 5 in the mechanisms of cardiac fibrosis, these pathways and the involved proteins are useful as therapeutic targets. However, because of the importance of these pathways in many other physiological functions, their therapeutic targeting needs to be approached with caution.

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“…12 The changes in myocardial architecture observed with fibrotic remodeling can be detrimental to heart function: Fibrous endocardial thickening of the right ventricular infundibulum is a predictor of poor right ventricular function in patients after tetralogy of Fallot repair. 3 In patients with tricuspid atresia myocardial fibrosis is associated with systolic ventricular dysfunction early in life. 4,13 In addition to being a mediator of cardiac dysfunction, diffuse fibrosis is the substrate for electric instability and a risk factor for life-threatening ventricular arrhythmia.…”

Section: Pathogenesis and Clinical Relevance Of Diffuse Myocardial Fimentioning

confidence: 99%

“…Diffuse fibrosis is regarded to be the common pathological pathway toward loss of myocardial function in many cardiac conditions, including congenital heart disease. [1][2][3][4] As fibrosis seems to have a major role in myocardial failure and may be reversible, [5][6][7][8] its assessment by CMR has the potential to transform the way we monitor and treat our patients. 9 In this review, we describe the technical aspects of fibrosis quantification with CMR and outline past and potential applications in congenital and pediatric heart disease.…”

mentioning

confidence: 99%