The impact of pre-operative serum creatinine on short-term outcomes after liver resection

Armstrong, Thomas; Welsh, Fenella; Wells, J. K.; Chandrakumaran, Kandiah; John, Timothy G.; Rees, Myrddin

doi:10.1111/j.1477-2574.2009.00094.x

Cited by 25 publications

(24 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite the differences in age and comorbidity, this study showed no difference in the rate of surgical complications between the two groups. Systemic complications accounted for the higher rates of postoperative morbidity in patients with elevated serum creatinine 27. In our study, creatinine was not significantly associated with posthemihepatectomy complications and also the grade of complication.…”

Section: Discussioncontrasting

confidence: 57%

Preoperative model for end-stage liver disease score as a predictor for posthemihepatectomy complications

Alghamdi¹,

Abdel-Fattah²,

Zautner³

et al. 2014

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

BackgroundAs diagnostic techniques advance and surgical outcomes improve, the rate of utilization of liver hemihepatectomy for various indications will continue to increase.ObjectivesTo explore the preoperative predictors of liver hemihepatectomy postoperative complications.Patients and methodsThis study included retrospective analysis of the clinical data of patients who underwent either liver hemihepatectomy or extended hemihepatectomy at Georg August University Hospital-Goettingen for the period 2002–2012. The outcomes were either postoperative complications or death of the patient (within 3 months from the end of the operation). Modified classification of surgical complications was adopted in the current study. The preoperative model for end-stage liver disease (MELD) score, aspartate aminotransferase, creatinine, international normalized ratio, and bilirubin in addition to the demographic characteristics of the patients and intraoperative blood loss were analyzed as predictive for postliver hemihepatectomy complications.ResultsThe study included 144 patients who underwent liver hemiheptectomy or extended hemihepatectomy through the study period (2002–2012). Postoperative complications were reported among patients out of 144 (52.1%). The most frequent complications were pleural effusion (26.7%), biliary leakage (21.3%), wound dehiscence (13.3%), ascites, and intra-abdominal abscess (6.7%). Death was reported among six patients of those who developed complications (8%). There were four cases of hepatic cirrhosis (one macroscopic and three microscopic). Two of the microscopic cases had no postoperative complications (grade 1), whereas one case had grade 3a and the macroscopic case had postoperative complication grade 1. Their MELD scores ranged between 6 and 10 preoperatively. The association between preoperative MELD score and development of posthemihepatetomy was statistically significant, P=0.002. Death was reported in six cases, yielding a mortality rate of 4.17%. MELD score preoperatively was the only significant predictor for postoperative complications.ConclusionThe rate of complications following hemihepatectomy remains high, with 52.1% of the patients in the current study having at least one complication as all of our patients underwent either hemihepatectomy or extended hemihepatectomy. A 4.17% mortality rate has been reported. A higher preoperative MELD score is the only significant predictor for the development of posthemihepatectomy complications.

show abstract

Section: Discussioncontrasting

confidence: 57%

Preoperative model for end-stage liver disease score as a predictor for posthemihepatectomy complications

Alghamdi¹,

Abdel-Fattah²,

Zautner³

et al. 2014

European Journal of Gastroenterology &Amp; Hepatology

View full text Add to dashboard Cite

show abstract

“…The effect of hepatic function on renal function is well known and of particular interest in patients with acute or chronic liver failure20. The impact of a raised preoperative serum creatinine level on postoperative renal function and non‐renal complications is well known21. The present evaluation of serum creatinine and urea levels in patients who had an uncomplicated hepatectomy revealed very constant levels of both parameters, with little fluctuation depending on the extent of resection.…”

Section: Discussionmentioning

confidence: 60%

Postoperative course and clinical significance of biochemical blood tests following hepatic resection

Reißfelder

Rahbari

Koch

et al. 2011

British Journal of Surgery

104

View full text Add to dashboard Cite

show abstract

“…Short-term outcomes of patients in this series are similar to those reported by other authors. [7][8][9][11][12][13][14][15][16]20 In one of the previous studies based on an unselected series of 1005 liver resections performed in the Department of General, Transplant and Liver Surgery at the Medical University of Warsaw, overall morbidity and mortality rates were 22.1% and 1.4%, respectively. 19 Although several studies have reported zero or near-zero mortality after a liver resection, most of these report only in-hospital or 30-day rates.…”

Section: Discussionmentioning

confidence: 99%

Early post‐operative prediction of morbidity and mortality after a major liver resection for colorectal metastases

Grąt

Hołówko

Lewandowski

et al. 2013

HPB

View full text Add to dashboard Cite

show abstract

The impact of pre-operative serum creatinine on short-term outcomes after liver resection

Abstract: After liver resection, renal failure is rare but patients with an elevated creatinine pre-operatively are at an increased risk of both renal and non-renal complications.

Cited by 25 publications

References 18 publications

Preoperative model for end-stage liver disease score as a predictor for posthemihepatectomy complications

Preoperative model for end-stage liver disease score as a predictor for posthemihepatectomy complications

Postoperative course and clinical significance of biochemical blood tests following hepatic resection

Early post‐operative prediction of morbidity and mortality after a major liver resection for colorectal metastases

Contact Info

Product

Resources

About