The impact of postoperative radiological surveillance intensity on disease free and overall survival from primary retroperitoneal, abdominal and pelvic soft-tissue sarcoma

Glasbey, James; Bundred, James; Tyler, Robert; Hunt, J.; Tattersall, Hannah L; Gourevitch, David; Almond, L. Max; Desai, Anant; Ford, Samuel J.

doi:10.1016/j.ejso.2021.01.021

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…Recurrence occurred in 60% of this cohort. There was no evidence of a positive association between survival benefit and more frequent follow-up in one UK single-centre retrospective analysis [ 7 ]. Indeed, for high-grade tumours, the disease-free survival was reduced, and no significant difference in reoperation rates following recurrence was seen [ 7 ].…”

Section: Optimal Surveillance Frequencymentioning

confidence: 99%

“…Through the centralisation of patient care at specialist centres, coupled with enhanced surgical techniques and multidisciplinary care, outcomes for patients with RPS have improved [ 2 , 3 , 4 ]. Nevertheless, overall 5-year survival across retroperitoneal sarcoma patients still sits around 60% [ 5 , 6 , 7 ]. The potential for disease recurrence, in the form of both loco-regional recurrence (LR) and distant metastasis (DM), underpins the rationale for post-operative surveillance across the spectrum of surgical oncology.…”

Section: Introductionmentioning

confidence: 99%

“…This is problematic due to the substantial differences in both methods of detecting recurrence and the consequences for patient outcomes [ 10 ]. Small observational retrospective data analyses of patients undergoing primary resection for RPS have failed to establish an overall survival benefit for high-intensity radiological surveillance for patients with high or low-grade disease [ 7 ]. The lack of a robust evidence base has given rise to variations in approaches to postoperative surveillance strategies adopted by specialist centres managing RPS across the world.…”

Section: Introductionmentioning

confidence: 99%

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Surveillance Post Surgery for Retroperitoneal Soft Tissue Sarcoma

et al. 2023

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Complete en bloc surgical resection offers the best opportunity for the cure of primary retroperitoneal sarcomas (RPS). The potential for disease recurrence, in the form of both loco-regional recurrence and distant metastases, underpins the rationale for postoperative surveillance. There is a paucity of high-quality evidence underpinning follow-up for RPS patients, and most practice guidelines draw from expert opinion and evidence from soft tissue sarcomas of the extremities. The available observational retrospective data analysis has failed to demonstrate that high-intensity radiological surveillance improves the overall survival in patients. The lack of a robust evidence base has given rise to variations in approaches to post-operative surveillance strategies adopted by specialist centres managing RPS across the world. More high-quality prospective research is needed and planned to more clearly support surveillance approaches that balance oncologic outcomes, patient-centric care, and health service value. Risk stratification tools exist and are available for use in routine practice. Their use will likely support more individualised post-operative surveillance moving forward. Surveillance will likely be underpinned by serial radiological imaging for the medium term. However, developments in genomics offer hope for biomarkers such as ctDNA to impact patient care positively in the future and further support individualised patient care pathways.

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Section: Optimal Surveillance Frequencymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Surveillance Post Surgery for Retroperitoneal Soft Tissue Sarcoma

et al. 2023

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“…In contrast to extremity STS, survival for patients with RPS is dictated by local or regional recurrences 11. Despite optimisation of surgical technique, local recurrence (LR) and distant metastatic disease (MD) remain common events,11–13 with a 5-year overall survival (OS) rate of 60% for RPS3 12–14 and long-term OS rates between 66%15 and 77%4—depending on tumour histology—for patients with extremity STS. Patterns and timings of recurrence are subject to histological subtype12 14 16–18 and tumour grade 18.…”

Section: Introductionmentioning

confidence: 99%

“…Postoperative surveillance is standard of care in all international high-volume sarcoma centres in the world and has rapidly evolved without an evidence base to become highly intensive and prolonged within most centres. The intensity of postoperative surveillance imaging is highly varied across centres throughout the world,1 9 13 18 reflecting a lack of evidence to guide decision-making. Current recommended follow-up protocols1 9 21–24 extrapolate from evidence in sarcoma of the limb25 26 and expert opinion 1 7 9 10…”

Section: Introductionmentioning

confidence: 99%

Experiences of patients and their relatives of postoperative radiological surveillance and surveillance intensity following primary resection of a soft tissue sarcoma and its impact on their quality of life: a systematic review protocol

et al. 2023

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IntroductionPostoperative radiological surveillance following primary resection of a soft tissue sarcoma (sarcoma of the retroperitoneum, abdomen, pelvis, trunk or extremities) is standard of care in all international high-volume sarcoma centres in the world. The intensity of postoperative surveillance imaging is highly varied and knowledge of the impact of surveillance and surveillance intensity on patients’ quality of life is limited. The aim of this systematic review is to summarise the experiences of patients and their relatives/caregivers of postoperative radiological surveillance following resection of a primary soft tissue sarcoma and its impact on their quality of life.Methods and analysisWe will systematically search MEDLINE, EMBASE, PsycINFO, CINAHL Plus and Epistemonikos. Hand searching of reference lists of included studies will be conducted. Further searches will be performed via Google Scholar, to reveal further studies within unpublished ‘grey’ literature. Two reviewers will independently screen the titles and abstracts following the eligibility criteria. After retrieval of the full text of the selected studies, the methodological quality will be appraised using the Joanna Briggs Institute Critical Appraisal Checklist for Qualitative Research and the Center for Evidence-Based Management checklist for Critical Appraisal of a Cross-Sectional Study. Data on the study population, relevant themes and conclusions will be extracted from the selected papers, and a narrative synthesis will be conducted.Ethics and disseminationThe systematic review does not require ethics approval. The findings of the proposed work will be published in a peer-reviewed journal and disseminated widely to patients, clinicians and allied health professionals through the Sarcoma UK website, the Sarcoma Patient Advocacy Global Network and the Trans-Atlantic Australasian Retroperitoneal Sarcoma Working Group. In addition, the outcomes of this research will be presented at national and international conferences.PROSPERO registration numberCRD42022375118.

The impact of postoperative radiological surveillance intensity on disease free and overall survival from primary retroperitoneal, abdominal and pelvic soft-tissue sarcoma

Cited by 7 publications

References 27 publications

Surveillance Post Surgery for Retroperitoneal Soft Tissue Sarcoma

Surveillance Post Surgery for Retroperitoneal Soft Tissue Sarcoma

Experiences of patients and their relatives of postoperative radiological surveillance and surveillance intensity following primary resection of a soft tissue sarcoma and its impact on their quality of life: a systematic review protocol

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