The impact of postoperative inflammation on recurrence in patients with colorectal cancer

Matsubara, Daiki; Arita, Tomohiro; Nakanishi, Masayoshi; Kuriu, Yoshiaki; Murayama, Yasutoshi; Kudou, Michihiro; Konishi, Hirotaka; Komatsu, Shuhei; Shiozaki, Atsushi; Otsuji, Eigo

doi:10.1007/s10147-019-01580-1

Cited by 46 publications

(38 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specifically, malnutrition may weaken the body's defense mechanisms, such as humoral and cellular immunity, leading to an increased likelihood of infection and poor response to anticancer treatment [46,47]. Excessive surgical stress and postoperative complications can also lead to a systemic inflammatory response, which promotes malnutrition and tumor progression, resulting in a poor prognosis of cancer patients [48][49][50]. As a response, advanced GC patients have been reported to benefit from nutritional improvement following nutritional support [51].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Albumin to D-Dimer Ratio in Advanced Gastric Cancer

Zhang

Wang²,

Xiao

et al. 2021

Journal of Oncology

View full text Add to dashboard Cite

Gastric cancer (GC) is one of the most common malignancies worldwide. Notably, patients with advanced GC have a poor prognosis and quality of life, prompting the need for further studies on its prognostic markers. Among these, albumin and D-dimer are often used as prognostic factors in the prediction of a variety of tumors. Moreover, the albumin to D-dimer ratio (ADR) may be an improved predictor of chemotherapy effect and survival compared to albumin and D-dimer alone, but few studies have investigated this issue. Thus, we explored the relationship between pretreatment ADR and prognosis in advanced GC treated with first-line chemotherapy. A total of 247 advanced unresectable GC patients treated with first-line chemotherapy were retrospectively included. The cut-off value for ADR was determined using the receiver operating characteristic (ROC) curve. The ADR had a cut-off value of 41.64. Compared to albumin and D-dimer alone, ADR had the highest area under curve (AUC) value (AUC = 0.730), followed by albumin (AUC = 0.659) and D-dimer (AUC = 0.719). Additionally, we found that patients with a low ADR (<41.64) had a lower disease control rate (77.9% vs. 92.5%, P < 0.01 ), shorter overall survival (OS) (271 vs. 389 days), and shorter progression-free survival (PFS) (118 vs. 192 days) than patients with a high ADR (≥41.64). Similar results were also found on subgroup analysis, and ADR was found to be an independent advanced GC prognostic factor on multivariate analysis (all P < 0.001 ). Low ADR was found to be correlated with poor therapeutic effects of chemotherapy and shortened OS and PFS. Therefore, pretreatment ADR may be a useful tool for predicting the effect of chemotherapy and prognosis in advanced GC patients treated with first-line chemotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Albumin to D-Dimer Ratio in Advanced Gastric Cancer

Zhang

Wang²,

Xiao

et al. 2021

Journal of Oncology

View full text Add to dashboard Cite

show abstract

“…However, chronic inflammation can interfere with normal homeostasis as it contributes to, among others, excessive cell proliferation and DNA damage [1,3]. Moreover, higher levels of inflammation markers, including C-reactive protein (CRP), Interleukin (IL)6, IL8, IL10 and tumor necrosis factor (TNF)a, have been associated with a worse progression free-, cancer specific-and overall survival [4e11] and a higher risk of CRC recurrence [12]. Diet has a marked effect on inflammation and subsequent health status [13].…”

Section: Introductionmentioning

confidence: 99%

The association between the adapted dietary inflammatory index and colorectal cancer recurrence and all-cause mortality

et al. 2021

View full text Add to dashboard Cite

“…Postoperative serum concentration of CRP is one of objective quantitative indices integrating the effects of preoperative comorbidities, surgical invasion, duration of surgery, anesthetic managements and analgesia [1,2]. Early increases in serum CRP concentrations after gastrointestinal surgery reportedly associate with postoperative complications [3][4][5][6][7][8][9][10] and cancer recurrence [11,12]. Therefore, perioperative managements aiming to prevent increases in CRP levels in the early postoperative period are relevant for better postoperative outcomes.…”

Section: Introductionmentioning

confidence: 99%

Modified model for predicting early C-reactive protein levels after gastrointestinal surgery: A prospective cohort study

et al. 2020

View full text Add to dashboard Cite

Background Postoperative serum concentration of C-reactive protein (CRP) is one of the objective quantitative indices integrating the effects of preoperative and intraoperative variables. Higher levels of CRP after gastrointestinal surgery are associated with major postoperative complications. To develop a model for predicting CRP levels on postoperative day (POD) 1 in surgical patients both with and without serious conditions and comorbidities, we modified the previous formula for prediction of CRP levels on POD1, and assessed the accuracy of our modified predictive formula for CRP levels. Material and methods Consecutive patients of all ages undergoing gastrointestinal surgery under general anesthesia were enrolled in this single-institution prospective cohort study. We developed a modified predictive formula in a calculation cohort. Next, associations between measured CRP levels on POD1, predicted CRP levels on POD1 using the previous and modified models, and major complications after surgery were examined in a validation cohort. Results We obtained the following model in the calculation cohort (n = 222): Modified model for predicting CRP levels on POD1 (mg•dL-1) =-10.13 + 0.0025 Duration of surgery (min) + 15.9 Mean Nociceptive Response (NR) + 0.66 Preoperative CRP level (mg•dL-1). In the validation cohort (n = 440), there was a significant association between measured and predicted CRP levels on POD1 (P < 0.001) No significant difference between the measured and predicted CRP levels using the modified model was observed (P = 0.847). There were also significant associations between the predicted CRP levels and major complications after surgery.

show abstract

The impact of postoperative inflammation on recurrence in patients with colorectal cancer

Cited by 46 publications

References 43 publications

Prognostic Value of Albumin to D-Dimer Ratio in Advanced Gastric Cancer

Prognostic Value of Albumin to D-Dimer Ratio in Advanced Gastric Cancer

The association between the adapted dietary inflammatory index and colorectal cancer recurrence and all-cause mortality

Modified model for predicting early C-reactive protein levels after gastrointestinal surgery: A prospective cohort study

Contact Info

Product

Resources

About