The Impact of Postoperative Complications on Long-term Quality of Life After Curative Colorectal Cancer Surgery

Brown, Sarah; Mathew, Ronnie; Keding, Ada; Marshall, Helen; Brown, Julia; Jayne, David

doi:10.1097/sla.0000000000000407

Cited by 166 publications

(116 citation statements)

References 25 publications

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“…Anastomotic leak after colorectal surgery increases postoperative morbidity, mortality, length of hospital stay, and nosocomial infection rates, and decreases quality of life (18,25,26). Moreover, anastomotic leak after colorectal cancer surgery may result in poor functional and oncological outcomes (27).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

Aghayeva

Benlice

Bilgin

et al. 2017

Tumori

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Introduction Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model. Methods Sixty Wistar albino rats were employed in the study. Sigmoid resection and end-to-end colorectal anastomosis was performed in all rats. Group 1 rats underwent the surgical procedure alone, while group 2 rats were given hyperthermic intraperitoneal lavage with heated saline following surgery. Groups 3, 4, 5, and 6 had surgery with concomitant HIPEC treatment with mitomycin C, cisplatin, oxaliplatin, and doxorubicin, respectively. Anastomotic bursting pressures and hydroxyproline levels were evaluated. Results Regarding the hydroxyproline levels, groups 1 and 2 showed significantly higher values than other groups (p<0.001). However, there was no significant difference between the HIPEC treatment groups (groups 3, 4, 5, and 6) (p>0.05). When groups were compared regarding bursting pressure values, no significant differences were observed (p = 0.81). Conclusions This study demonstrated that the HIPEC procedure with mitomycin C, cisplatin, oxaliplatin and doxorubicin had negative effects on hydroxyproline levels, but had no detrimental effect on anastomotic bursting pressure in a rat model.

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Section: Discussionmentioning

confidence: 99%

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

Aghayeva

Benlice

Bilgin

et al. 2017

Tumori

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“…However, Brown et al have shown adverse effects in long-term quality of life in patients with postoperative complications. [14] From this aspect, it has come to our attention that short-term outcomes of laparoscopic colorectal surgery are probably better from open surgery, but the outcomes of patients with conversion are less favorable. Designed as a case-controlled study, same number of patients in both groups were included into the study.…”

Section: Discussionmentioning

confidence: 99%

The comparison of laparoscopic and conventional surgery for colorectal cancers: Evaluation of the initial experience

Çetinkünar¹

2017

Laparosc Endosc Surg Sci

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“…Thus disability has been assessed in several studies of cancer patients. 3,8 Recently, Khoei et al 32 proved that the Katz index is a reliable instrument for oncologic patients using the Physical Function subscale of SF 36 as criterion of validity (Cronbach's alpha 0.923).…”

Section: Discussionmentioning

confidence: 99%

“…3, 8 The present study has several shortcomings. First, ADL and HRQoL were not compared before and after surgery.…”

mentioning

confidence: 93%

Disability and Quality of Life after Surgery for Cancer

Benítez¹,

García²,

Noyola³

et al. 2017

HPMIJ

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Abbreviations: HRQoL, health related quality of life; ADL, activities of daily living; QoL, quality of life; IOR, institute of oncology and radiobiology; ACCI, adjusted charlson comorbidity index; ASA, american society of anaesthesiology; APCHE, acute physiology and chronic health evaluation; VAS, visual analogue scale; IQR, interquartile range; PS, performance status IntroductionCancer is one of first cause of death around the world and Cuba.1 Surgery is one of most important therapeutic tool for its control, either for curative or palliative purpose. Although surgical intervention can be a life-saviour strategy for these patients, several complications could be present in postoperative period, 2 as well as limitations for activities of daily living (ADL) and derangement in quality of life (QoL).3 Postoperative recovery is a dynamic process where biological, physiological, functional and psychological components play a pivotal role. A rise in physical independence and gradual return to ADL are global indicator of functional recovery after surgery. For most patients, the evaluation of ADL is only performed during their hospital stay. Traditionally, patients should probe their capacity to walking, eating, bathing and dressing without help. 4Elderly patients are a special increasing subgroup.5 Because of the ageing-related characteristics, this population has a decreased functional capacity even before hospital admission.6 According to literature reports, more than 10% of elderly patients develop a severe postoperative disability.7 Postoperative evaluations of functional capacity and health-related QoL (HRQoL) have been become as an important component of long-term surgical outcomes, particularly in the elderly population. 8-11The problem is more serious in the case of cancer patients because a higher prevalence of malignancies among the elderly subgroup. 12,13Frequently, surgical indication for elderly patients with comorbidities is based on subjective judgement according to the personal experience of surgeon. In addition, a negative attitude regarding elderly patients can be see among some physicians, which lead to patients with acceptable functional status could be not surgically treated as usually is indicated for younger patients. Furthermore, radical surgical interventions are neither performed in elderly population. This is significant because currently the primary tumour and regional lymphatic node can only be removed by radical intervention with surgical margin, which guarantees a higher probability of cure. 14,15This study was aimed to assess the prevalence of disability and healthrelated quality of life, as well as related risk factors among patients operated for gastrointestinal or thoracic cancer. Methods Design and settingThis retrospective study was conducted in the oncological ICU (OICU) of the Institute of Oncology and Radiobiology (IOR). This is a 220-bed, university-affiliated, tertiary care referral centre for cancer patients in Havana, Cuba. The OICU has 12 beds and provides care for about 400...

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The Impact of Postoperative Complications on Long-term Quality of Life After Curative Colorectal Cancer Surgery

Abstract: Postoperative complications have adverse effects on long-term QoL, particularly for Physical, Role and Social Functioning, and Body Image, as well as for Mobility, Self-care, and Pain/Discomfort. These findings should inform future preoperative counseling and health care planning.

Cited by 166 publications

References 25 publications

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

The comparison of laparoscopic and conventional surgery for colorectal cancers: Evaluation of the initial experience

Disability and Quality of Life after Surgery for Cancer

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