The impact of phytochemicals present in the diet on microbial signalling in the human gut

McCarthy, Ronan R.; O’Gara, Fergal

doi:10.1016/j.jff.2015.02.032

Cited by 17 publications

(13 citation statements)

References 58 publications

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“…Therefore, disrupting the AHLs would be a useful target for anti-pathogenic therapy in preventing QS-dependent bacterial infections (Hentzer and Givskov, 2003). Numerous AHLs were found in food and are able to modulate the immune system exacerbating the proinflammatory response (McCarthy and O’Gara, 2015).…”

Section: Resultsmentioning

confidence: 99%

“…This mechanism is mediated by N -acyl homoserine lactones (AHLs), which are small diffusible molecules, termed as autoinducers, produced and secreted by the bacteria. AHL can be found in a wide range of foods (Blana and Nychas, 2014; McCarthy and O’Gara, 2015), with no possibility of inactivation at 100 ℃, suggesting the risk of the presence of these molecules in food (Wang et al., 2013). On the other hand, Pseudomonas spp.…”

Section: Introductionmentioning

confidence: 99%

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Grapefruit essential oils inhibit quorum sensing of Pseudomonas aeruginosa

Luciardi

Blázquez

Cartagena

et al. 2019

Food sci. technol. int.

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Citrus essential oils are used in food to confer flavor and aromas. The citrus essential oils have been granted as GRAS and could be used as antimicrobial additives to control bacterial quorum sensing from potential food bacterial pathogens. The chemical composition and inhibitory activity of Citrus paradisi (grapefruit) essential oils obtained by cold-pressed method (EOP) and cold-pressed method followed by steam distillation, against Pseudomonas aeruginosa were determined . The GC-MS analyses of the oil indicated the amount of the essential oil components was highest with D-limonene in both cases. However, the extraction method modified the chemical composition. EOP had higher amount of coumarins and flavonoid as well as less oxygenated terpenoids. At 0.1 mg/mL essential oils were not able to modify the bacterial development but inhibited the P. aeruginosa biofilm production between 52% and 55%, sessile viability between 45% and 48%, autoinducer production and elastase activity between 30% and 56%. Limonene was less effective at inhibiting P. aeruginosa than the essential oils, suggesting a synergistic effect of the minor components. According to our results, grapefruit essential oils could be used as a food preservative to control P. aeruginosa virulence.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Grapefruit essential oils inhibit quorum sensing of Pseudomonas aeruginosa

Luciardi

Blázquez

Cartagena

et al. 2019

Food sci. technol. int.

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“…The authors reported a reduction in the MICs of azithromycin and gentamycin when they were combined with curcumin. Similarly, McCarthy and Ogara (2015) found that garlic ( Allium sativum ) extract synergized with tobramycin to kill P. aeruginosa . They concluded that garlic extract not only decrease the pathogenicity of bacteria but also increased microbial susceptibility to antibiotics.…”

Section: Discussionmentioning

confidence: 97%

Anti-biofilm Potential of Elletaria cardamomum Essential Oil Against Escherichia coli O157:H7 and Salmonella Typhimurium JSG 1748

et al. 2021

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Foodborne pathogens, microbial recurrent infections, and antibiotic resistance have driven researchers to explore natural compounds as safe alternative antimicrobials. In this study, the chemical profile, antimicrobial, and mutagenic activities of the Elletaria cardamomum essential oil were investigated. GC-MS analysis identified the major bioactive components as α-terpinyl acetate, 1,8-cineole, linalool acetate, and sabinene, at concentrations of 34.95, 25.30, 8.13, and 5.48% respectively, of the essential oil’s content. Regarding antimicrobial activity, the minimum inhibitory concentration of green cardamom essential oil was 1% against Escherichia coli O157:H7 and Pseudomonas aeruginosa ATCC 14213. Green cardamom essential oil, when used at concentrations of 0.015, 0.031, 0.062, and 0.125% (v/v) prevented biofilm formation of Escherichia coli O157:H7 by 64.29, 65.98, 70.41, and 85.59%, respectively. Furthermore, these concentrations inhibited 6.13, 45.50, 49.45, and 100%, respectively, of the Salmonella Typhimurium JSG 1748 biofilm. A mutagenicity assay confirmed that green cardamom essential oil has no demonstrable mutagenic activity against the tested strains. The study’s findings suggest that green cardamom derived bioactive compounds are safe organic antimicrobials, effective in controlling biofilm formation by Gram-negative pathogens. Moreover, such compounds could possibly be used in the food industry (e.g., bakery, dairy, meat, and other food products) as a safe alternative to chemical preservatives (antimicrobials) to enhance shelf life by improving the antimicrobial status while at the same time imparting a pleasant and appealing aroma for consumers.

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“…The first is in Cinnamomum and grapes, and the second is a whiskey scent and wine, among others. It has been proposed that the inhibitory molecules of quorum sensing present in food could contribute to avoidance of the formation of biofilm, thus reducing the risk of recurrent hospital infections and at the same time increasing the sensitivity to antibiotics [22,23]. Thus, it has been reported that garlic extract (rich in ajoene content, with anti- QS activity), supplied with the antibiotic tobramycin in vitro and in vivo, significantly reduced the formation of biofilm in Pseudomonas aeruginosa [24,25].…”

Section: Discussionmentioning

confidence: 99%

The Search for Natural Inhibitors of Biofilm Formation and the Activity of the Autoinductor C6-AHL in Klebsiella pneumoniae ATCC 13884

Cadavid

Echeverri

2019

Biomolecules

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Human nosocomial infections are common around the world. One of the main causes is the bacteria Klebsiella pneumoniae, which shows high rates of resistance to antibiotics. Thus, drugs with novel mechanisms of action are needed. In this work, we report the effects of various natural substances on the formation of biofilm in Klebsiella pneumoniae, as well as its stability. The effect of the molecules on the growth of K. pneumoniae was initially determined by measuring the optical density. The modification of the biofilm, the changes relating to its resistance, the effects on the bacterial adhesion to the urethral catheter and its antagonist role the hexanoyl-homoserinelactone were assessed by crystal violet, as well as by microscopy. The best effects were obtained with 3-methyl-2(5H)-furanone and 2´-hydroxycinnamic acid, which inhibited the formation of biofilm by 67.38% and 65.06%, respectively. Additionally, the remaining biofilm formed was more susceptible to gentamicin. Through microscopy examination, there were evident changes in the biofilm and adherence on the polyvinyl chloride (PVC) urethral catheter. Besides, 3-methyl-2(5H)-furanone inhibited the biofilm-forming effect of the autoinducer hexanoyl-homoserinelactone. Thus, these molecules could be developed as supplemental of antibiotics.

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The impact of phytochemicals present in the diet on microbial signalling in the human gut

Cited by 17 publications

References 58 publications

Grapefruit essential oils inhibit quorum sensing of Pseudomonas aeruginosa

Grapefruit essential oils inhibit quorum sensing of Pseudomonas aeruginosa

Anti-biofilm Potential of Elletaria cardamomum Essential Oil Against Escherichia coli O157:H7 and Salmonella Typhimurium JSG 1748

The Search for Natural Inhibitors of Biofilm Formation and the Activity of the Autoinductor C6-AHL in Klebsiella pneumoniae ATCC 13884

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