The impact of personality disorder pathology on the effectiveness of Cognitive Therapy and Interpersonal Psychotherapy for Major Depressive Disorder

Abstract

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Interpersonal Psychotherapy Versus Cognitive Therapy for Depression: How They Work, How Long, and for Whom—Key Findings From an RCT

“…Because depression is a disorder with high comorbidity, especially anxiety and personality pathology, we also examined the (differential) effect of baseline comorbid anxiety and personality pathology on outcome (11,12). We looked at both full disorder diagnoses as well as symptoms and/or traits of disorders.…”

“…The fact that there were differences in the occurrence of sudden gains in two treatments that overall showed similar outcomes must reflect different mechanisms of change. Furthermore, the identification of various moderators (8,11,12) also suggests differential pathways of change (20).…”

“…In this overview, the methods, key findings, and conclusions of this trial are summarized. Our earlier publications (6)(7)(8)(9)(10)(11)(12)(13)(14) contain extensive discussion of the extant literature and details about the study design, participants, procedures, assessment instruments, quality of the interventions, analytical procedures, and outcomes.…”

Influence of apparently negative personality characteristics on the long‐term outcome of health anxiety: Secondary analysis of a randomized controlled trial

“…There are also conflicting data of the influence of personality disorder on specific treatments for mood disorders, ranging from no differences to better results with drug or psychological treatment depending on the population chosen 8–10 . There is one small study hinting that Cluster A personality disorder improves outcome in cognitive behaviour therapy for depression 11 …”

The importance of assessing personality traits and disorders in clinical trials of major depressive disorder

“…6 Similarly, in a recent trial of cognitive behavior therapy and interpersonal therapy in patients with MDD and comorbid PD, the presence of a PD had no meaningful impact on treatment response or treatment retention in either modality. 7 Given the high prevalence of comorbid PD and MDD and the conflicting evidence on whether this contributes to treatment resistance, we propose that a structured assessment of personality traits and disorders could be incorporated in RCTs of interventions for MDD. The study by Kavanagh et al 8 in the current issue was designed to provide such information.…”