The impact of perioperative high-protein oral nutrition supplements on postoperative outcomes in primary lung cancer: the protocol of Russian prospective, randomised, multicenter study

Abstract

Abstract.
 Rationale. Nutritional support, including sips, is an integral part of anticancer treatment, including during surgical treatment of non-small cell lung cancer (NSCLC). Existing evidence for the effectiveness of nutritional support in this cohort of patients is limited. We suggest that the perioperative administration of a balanced polymeric hypercaloric high-protein enteral nutritional formula by sipping as an additional nutrition can have a positive effect on the results of surgical treatment.
 Material and methods. Russian multicenter comparative low-intervention study of the effect of perioperative high-protein nutritional support on postoperative outcomes in the treatment of primary lung cancer with parallel groups, 1:1 randomization. The study will include 114 patients with newly diagnosed NSCLC who are scheduled for surgery. It is expected to provide nutritional support in the perioperative period for 14 days before surgery and for 14 days after it.
 Discussion. The need for nutritional support in oncology is not in doubt, but its impact on the results of surgical treatment of NSCLC is not numerous. The present study may become one of the first evidence-based studies confirming the effectiveness of perioperative nutritional support with high-protein mixtures in patients with NSCLC and will allow further study of the strategy of nutritional support in this category of patients.
 Registration of the study. Protocol version and date: NUTRILUNC v.1.2 dated June 10, 2022. Study ID: РНИ.40.002. The study is registered in the register NARNIS (https://narnis.ru).