The impact of periodontitis in the course of chronic obstructive pulmonary disease: Pulmonary and systemic effects

Rosa, Ellen Perim; Murakami-Malaquias-da-Silva, Felipe; Palma-Cruz, Marlon; Garcia, Geovana de Carvalho; Brito, Auriléia Aparecida de; Andreo, Lucas; Kamei, Sergio Koiti; Negreiros, Renata Matalon; Rodrigues, Maria Fernanda De Souza Setubal Destro; Mesquita‐Ferrari, Raquel Agnelli; Bussadori, Sandra Kalil; Fernandes, Kristianne Porta Santos; Oliveira, Ana Paula Ligeiro de; Lino-dos-Santos-Franco, Adriana; Horliana, Anna Carolina Ratto Tempestini

doi:10.1016/j.lfs.2020.118257

Cited by 11 publications

(9 citation statements)

References 77 publications

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“…In fact, diverse authors have also found values higher than 50 pg/ml in BALF of mice from the Basal group (33)(34)(35)(36). Our results are in accordance with findings in which IL-10 level in BALF of the Basal group reached 1,500 pg/ml (37). Although our results are in agreement with studies, the values of IL-10 found in BALF of Basal groups is truly elevated; however, it does not seem to be a discrepant result since, regardless of IL-10 values in the Basal group, it is important to highlight that the BALF IL-10 level in the Basal group is higher than values of pro-inflammatory mediators found also in the Basal group.…”

Section: Discussionsupporting

confidence: 92%

Photobiomodulation Therapy Restores IL-10 Secretion in a Murine Model of Chronic Asthma: Relevance to the Population of CD4+CD25+Foxp3+ Cells in Lung

Brito¹,

Herculano²,

Estefano-Alves³

et al. 2022

Front. Immunol.

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It is largely known that photobiomodulation (PBM) has beneficial effects on allergic pulmonary inflammation. Our previous study showed an anti-inflammatory effect of the PBM in an acute experimental model of asthma, and we see that this mechanism is partly dependent on IL-10. However, it remains unclear whether the activation of regulatory T cells is mediated by PBM in a chronic experimental model of asthma. In this sense, the objective of this study was to verify the anti-inflammatory role of the PBM in the pulmonary inflammatory response in a chronic experimental asthma model. The protocol used for asthma induction was the administration of OVA subcutaneously (days 0 and 14) and intranasally (3 times/week, for 5 weeks). On day 50, the animals were sacrificed for the evaluation of the different parameters. The PBM used was the diode, with a wavelength of 660 nm, a power of 100 mW, and 5 J for 50 s/point, in three different application points. Our results showed that PBM decreases macrophages, neutrophils, and lymphocytes in the bronchoalveolar lavage fluid (BALF). Moreover, PBM decreased the release of cytokines by the lung, mucus, and collagen in the airways and pulmonary mechanics. When we analyzed the percentage of Treg cells in the group irradiated with laser, we verified an increase in these cells, as well as the release of IL-10 in the BALF. Therefore, we conclude that the use of PBM therapy in chronic airway inflammation attenuated the inflammatory process, as well as the pulmonary functional and structural parameters, probably due to an increase in Treg cells.

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Section: Discussionsupporting

confidence: 92%

Photobiomodulation Therapy Restores IL-10 Secretion in a Murine Model of Chronic Asthma: Relevance to the Population of CD4+CD25+Foxp3+ Cells in Lung

Brito¹,

Herculano²,

Estefano-Alves³

et al. 2022

Front. Immunol.

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“…Furthermore, periodontitis decreased macrophages, TNF-α, and INF-γ expression in a mouse model of chronic obstructive pulmonary disease (COPD). Periodontitis may influence the course of Th1 profile cells, cytokines, and pulmonary alterations [104].…”

Section: Other Disease Model Mice With Ligature-induced Periodontitismentioning

confidence: 99%

Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease

Lin

Niimi

Ohsugi

et al. 2021

IJMS

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Periodontitis is an inflammatory disease characterized by the destruction of the periodontium. In the last decade, a new murine model of periodontitis has been widely used to simulate alveolar bone resorption and periodontal soft tissue destruction by ligation. Typically, 3-0 to 9-0 silks are selected for ligation around the molars in mice, and significant bone loss and inflammatory infiltration are observed within a week. The ligature-maintained period can vary according to specific aims. We reviewed the findings on the interaction of systemic diseases with periodontitis, periodontal tissue destruction, the immunological and bacteriological responses, and new treatments. In these studies, the activation of osteoclasts, upregulation of pro-inflammatory factors, and excessive immune response have been considered as major factors in periodontal disruption. Multiple genes identified in periodontal tissues partly reflect the complexity of the pathogenesis of periodontitis. The effects of novel treatment methods on periodontitis have also been evaluated in a ligature-induced periodontitis model in mice. This model cannot completely represent all aspects of periodontitis in humans but is considered an effective method for the exploration of its mechanisms. Through this review, we aimed to provide evidence and enlightenment for future studies planning to use this model.

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“…The latest study suggests that this may be attributed to periodontitis affecting Th1 pro le cell processes, cytokines, and pulmonary alterations (11), which is further corroborated by transcriptomic analysis (12). However, the current evidence is, at best, indirectly supportive of the link between COPD and periodontitis.…”

Section: Discussionmentioning

confidence: 64%

“…In previous studies, COPD has been reported to be associated with oral disease, especially periodontitis (8-10). Some studies have suggested that these associations may be established through systemic immunity and in ammation (11,12). However, some studies have not found a relationship between typical periodontitis and COPD (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Causal association between oral disease and chronic obstructive pulmonary disease: A Mendelian Randomization study

Cao

Zeng

et al. 2023

Preprint

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Background The association between oral diseases and chronic obstructive pulmonary disease (COPD) has been revealed by many epidemiological studies in clinical aspects. Therefore, we elucidate genetic relationships using Mendelian randomization (MR) in this study. Method We utilized MR analysis with summary datasets from a genome-wide association study (GWAS) to investigate the causal relationship between COPD and 12 oral traits such as periodontitis and denture and ensured that there were no confounders like smoking, and every F-value was greater than 10. Inverse variance weighting (IVW) was applied with MR analysis as the primary outcome. Additionally, the horizontal pleiotropy was assessed by MR-PRESSO methods, and the heterogeneity was detected using Cochran's Q statistics. Result This study found a significant causal effect of implant dentures on COPD by univariate and multivariate MR (OR = 1.077, 95%CI = 1.044 ~ 1.111, p_adjust = 6.58E-05). Although univariate MR showed that excessive attrition of teeth had a significant causal effect on later COPD (OR = 1.061, 95%CI = 1.020 ~ 1.104, p_adjust = 0.037), this causal relationship was not found in multivariate MR. This study found no significant effect of periodontitis on COPD (p > 0.05), either acute or chronic. Conclusion Our MR Analysis findings suggested that implant dentures and excessive attrition of teeth significantly promotes the risk of COPD and elder COPD, respectively. However, the evidence for a causal relationship between periodontitis and COPD is still insufficient and previous studies may have been affected by confounding factors.

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The impact of periodontitis in the course of chronic obstructive pulmonary disease: Pulmonary and systemic effects

Cited by 11 publications

References 77 publications

Photobiomodulation Therapy Restores IL-10 Secretion in a Murine Model of Chronic Asthma: Relevance to the Population of CD4+CD25+Foxp3+ Cells in Lung

Photobiomodulation Therapy Restores IL-10 Secretion in a Murine Model of Chronic Asthma: Relevance to the Population of CD4+CD25+Foxp3+ Cells in Lung

Application of Ligature-Induced Periodontitis in Mice to Explore the Molecular Mechanism of Periodontal Disease

Causal association between oral disease and chronic obstructive pulmonary disease: A Mendelian Randomization study

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