The impact of pediatric obesity on hospitalized children with lower respiratory tract infections in the United States

Okubo, Yusuke; Nochioka, Kotaro; Testa, Marcia A.

doi:10.1111/crj.12694

Cited by 30 publications

(31 citation statements)

References 23 publications

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“…Obesity is an economically complicating factor for children hospitalized with respiratory infections and asthma in the United States and Japan, where nationwide studies from 2000 to 2012 revealed that obesity was consistently associated with increased hospitalization costs and prolonged length of hospital stay among children with pneumonia or asthma . In contrast, our results demonstrated that the differences in total costs were insignificant between underweight, normal‐weight, overweight, and obese infants.…”

Section: Discussioncontrasting

confidence: 65%

“…Most previous studies have focused on the burden of obesity on respiratory infections, categorizing underweight subjects together with normal‐weight subjects as non‐obese . Therefore, little is known about the effects of underweight status.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…Obesity has been reported to aggravate the manifestations of lower respiratory infections . Previous studies demonstrated that obesity was an independent risk factor for hospital admission, greater need for intensive care, prolonged length of hospital stay, and elevated healthcare costs in children hospitalized with respiratory infections . Recently, a retrospective medical chart review study was conducted at a single institution in Japan, and found that underweight and obesity were associated with prolonged respiratory symptoms among children aged 1‐6 years who were hospitalized with RSV infections .…”

Section: Introductionmentioning

confidence: 99%

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Dose‐dependent relationships between weight status and clinical outcomes among infants hospitalized with respiratory syncytial virus infections

Okubo

Morisaki

Michihata

et al. 2018

Pediatric Pulmonology

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Section: Discussioncontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dose‐dependent relationships between weight status and clinical outcomes among infants hospitalized with respiratory syncytial virus infections

Okubo

Morisaki

Michihata

et al. 2018

Pediatric Pulmonology

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“…The prevalence of childhood obesity increased between the period from 1990 to 2007 and then leveled off . Recently, several studies have reported that paediatric obesity was associated with high illness severity for acute and chronic diseases, and the health care costs attributable to obesity were gradually rising …”

Section: Introductionsupporting

confidence: 84%

Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014

2019

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Background: Several studies have reported bisphenol A (BPA) as a potential risk factor for paediatric obesity, but the findings were inconsistent among these studies. Methods:Using data from the National Health and Nutrition Examination Survey from 2003 to 2014, we conducted a serial cross-sectional study to examine the association between urinary BPA and paediatric obesity among children aged 6 and 19 years. The association between paediatric obesity and urinary BPA concentrations with or without urinary creatinine adjustments was assessed using multivariable regression and cubic spline models fitted for regression models. Results:We observed decreasing trends in urinary BPA concentrations from 2003 to 2014. The associations between urinary BPA concentrations and obesity were inconsistent across the years of survey and even after different models for urinary creatinine adjustments were used. Children with obesity were positively associated with urinary creatinine concentrations, but was not with creatinine-adjusted models.Furthermore, children with higher urinary BPA concentrations had elevated odds of obesity during 2003 to 2008, whereas these associations were inconsistent during 2009 to 2014. Conclusions:The associations between paediatric obesity and urinary BPA concentrations differed across the years of survey and creatinine adjustments. Further studies are required to assess these discrepancies. KEYWORDSurinary bisphenol A, cubic spline model

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Impact of obstructive sleep apnea on assisted ventilation in children with asthma exacerbation

Tsou

Cielo

Xanthopoulos

et al. 2021

Pediatric Pulmonology

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Objective To determine the impact of obstructive sleep apnea (OSA) on asthma exacerbation severity in children hospitalized for asthma exacerbation. Hypothesis OSA is associated with greater use of invasive mechanical ventilation (IMV) and noninvasive mechanical ventilation (NIMV) in children hospitalized for asthma exacerbation. Study Design A retrospective cohort study. Patient–Subject Selection Hospitalization records of children aged 2–18 years admitted for acute asthma exacerbation were obtained for 2000, 2003, 2006, 2009, and 2012 from the Kids’ Inpatient Database. Methodology The primary exposure was OSA, the primary outcome was IMV, and secondary outcomes were NIMV, length of hospital stay (LOS), and inflation‐adjusted cost of hospitalization. Multivariable logistic regression, negative binomial, and linear regression were conducted to ascertain the impact of OSA on primary and secondary outcomes. Exploratory analyses investigated the impact of obesity on primary and secondary outcomes. Results Among 564,467 hospitalizations for acute asthma exacerbation, 4209 (0.75%) had OSA. Multivariable regression indicated that OSA was associated with IMV (adjusted odds ratio [OR], 5.33 [95% confidence interval, CI: 4.35–6.54], p < .0001), NIMV (adjusted OR, 8.30 [95% CI: 6.56–10.51], p < .0001), longer LOS (adjusted incidence rate ratio, 1.34 [95% CI 1.28–1.43], p < .0001), and greater inflation‐adjusted cost of hospitalization (adjusted β, 0.38 [95% CI: 0.33–0.43], p < .0001). Obesity was also significantly associated IMV, NIMV, longer LOS, and greater inflation‐adjusted cost of hospitalization. There was no interaction between OSA and obesity. Conclusion OSA is an independent risk factor for IMV, NIMV, longer LOS, and elevated inflation‐adjusted costs of hospitalization in children hospitalized for asthma exacerbation.

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The impact of pediatric obesity on hospitalized children with lower respiratory tract infections in the United States

Abstract: Pediatric obesity is an independent risk factor for severity and morbidity among pediatric patients with lower respiratory tract infections. These findings suggest the importance of obesity prevention for pediatric populations.

Cited by 30 publications

References 23 publications

Dose‐dependent relationships between weight status and clinical outcomes among infants hospitalized with respiratory syncytial virus infections

Dose‐dependent relationships between weight status and clinical outcomes among infants hospitalized with respiratory syncytial virus infections

Serial cross‐sectional study for the association between urinary bisphenol A and paediatric obesity: Recent updates using NHANES 2003‐2014

Impact of obstructive sleep apnea on assisted ventilation in children with asthma exacerbation

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