The impact of particulate matters on apoptosis in various organs: Mechanistic and therapeutic perspectives

Aghaei-Zarch, Seyed Mohsen; Nia, Amir Hosein Sanjari; Nouri, Morteza; Mousavinasab, Fatemehsadat; Najafi, Sajad; Bagheri-Mohammadi, Saeed; Aghaei-Zarch, Fatemehsadat; Toolabi, Ali; Rasoulzadeh, Hassan; Ghanavi, Jalaledin; Moghadam, Masomeh Nasiri; Talebi, Mehrdad

doi:10.1016/j.biopha.2023.115054

Cited by 8 publications

(2 citation statements)

References 96 publications

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“…This suggests a potential avenue for further investigation into ferroptosis, a form of iron-dependent cell death. In addition to ferroptosis, which is the focus of our research, cell death induced by particulate matter is diverse in many studies, predominantly involving apoptosis, autophagy, and necrosis [ 122 , 123 , 124 ]. Therefore, further studies on diverse forms of cell death would be an interesting avenue for future research.…”

Section: Discussionmentioning

confidence: 99%

Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells

Ahn,

Yim,

Yoo

2024

Toxics

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Numerous toxicological studies have highlighted the association between urban particulate matter (PM) and increased respiratory infections and lung diseases. The adverse impact on the lungs is directly linked to the complex composition of particulate matter, initiating reactive oxygen species’ (ROS’) production and consequent lipid peroxidation. Excessive ROS, particularly within mitochondria, can destroy subcellular organelles through various pathways. In this study, we confirmed the induction of ferroptosis, an iron-dependent cell death, upon exposure to an urban PM using RT-qPCR and signaling pathway analysis. We used KRISS CRM 109-02-004, the certified reference material for the analysis of particulate matter, produced by the Korea Research Institute of Standards and Science (KRISS). To validate that ferroptosis causes lung endothelial toxicity, we assessed intracellular mitochondrial potential, ROS overproduction, lipid peroxidation, and specific ferroptosis biomarkers. Following exposure to the urban PM, a significant increase in ROS generation and a decrease in mitochondrial potential were observed. Furthermore, it induced hallmarks of ferroptosis, including the accumulation of lipid peroxidation, the loss of antioxidant defenses, and cellular iron accumulation. In addition, the occurrence of oxidative stress as a key feature of ferroptosis was confirmed by increased expression levels of specific oxidative stress markers such as NQO1, CYP1B1, FTH1, SOD2, and NRF. Finally, a significant increase in key ferroptosis markers was observed, including xCT/SLC7A11, NQO1, TRIM16, HMOX-1, FTL, FTH1, CYP1B1, CHAC1, and GPX4. This provides evidence that elevated ROS levels induce oxidative stress, which ultimately triggers ferroptosis. In conclusion, our results show that the urban PM, KRISS CRM, induces cellular and mitochondrial ROS production, leading to oxidative stress and subsequent ferroptosis. These results suggest that it may induce ferroptosis through ROS generation and may offer potential strategies for the treatment of lung diseases.

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Section: Discussionmentioning

confidence: 99%

Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells

Ahn,

Yim,

Yoo

2024

Toxics

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“…Herbal extracts have historically been acknowledged for their antimicrobial, antidepressant, anti-inflammatory, expectorant, immune-enhancing, and potential anticancer properties. Similar to other therapeutic modalities, individuals may choose to utilize herbal medicine as a means to promote overall well-being [ 95 ]. Among the realm of alternative and complementary medicines, herbal remedies are frequently employed by individuals, particularly those who have been diagnosed with various types of cancer [ 96 ].…”

Section: Introductionmentioning

confidence: 99%

Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance

Huang,

Azizi,

Vazirzadeh

et al. 2023

J Transl Med

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Cancer is a complex disease with many contributing factors, and researchers have gained extensive knowledge that has helped them understand the diverse and varied nature of cancer. The altered patterns of DNA methylation found in numerous types of cancer imply that they may play a part in the disease’s progression. The human cancer condition involves dysregulation of the DNA methyltransferase 3 beta (DNMT3B) gene, a prominent de novo DNA methyltransferase, and its abnormal behavior serves as an indicator for tumor prognosis and staging. The expression of non-coding RNAs (ncRNAs), which include microRNAs (miRNA), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), is critical in controlling targeted gene expression and protein translation and their dysregulation correlates with the onset of tumors. NcRNAs dysregulation of is a critical factor that influences the modulation of several cellular characteristics in cancerous cells. These characteristics include but are not limited to, drug responsiveness, angiogenesis, metastasis, apoptosis, proliferation, and properties of tumor stem cell. The reciprocal regulation of ncRNAs and DNMT3B can act in synergy to influence the destiny of tumor cells. Thus, a critical avenue for advancing cancer prevention and treatment is an inquiry into the interplay between DNMT3B and ncRNAs. In this review, we present a comprehensive overview of the ncRNAs/DNMT3B axis in cancer pathogenesis. This brings about valuable insights into the intricate mechanisms of tumorigenesis and provides a foundation for developing effective therapeutic interventions.

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The research progress of crosstalk mechanism of autophagy and apoptosis in diabetic vascular endothelial injury

Liu,

Yao,

Wang

et al. 2024

Biomedicine & Pharmacotherapy

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The impact of particulate matters on apoptosis in various organs: Mechanistic and therapeutic perspectives

Cited by 8 publications

References 96 publications

Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells

Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells

Non-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance

The research progress of crosstalk mechanism of autophagy and apoptosis in diabetic vascular endothelial injury

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