The impact of Parkinson’s disease on striatal network connectivity and cortico-striatal drive: an in-silico study
Ilaria Carannante,
Martina Scolamiero,
J. J. Johannes Hjorth
et al.
Abstract:Striatum, the input stage of the basal ganglia, is important for sensory-motor integration, initiation and selection of behaviour, as well as reward learning. Striatum receives glutamatergic inputs from mainly cortex and thalamus. In rodents, the striatal projection neurons (SPNs), giving rise to the direct and the indirect pathway (dSPNs and iSPNs, respectively), account for 95% of the neurons and the remaining 5% are GABAergic and cholinergic interneurons. Interneuron axon terminals as well as local dSPN and… Show more
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