The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage)

Diabetes mellitus remains one of the leading causes of morbidity and mortality worldwide. According to the Centers for Disease Control and Prevention, approximately 23.6 million people in the United States are affected. Of these individuals, 5-10% have been diagnosed with type 1 diabetes mellitus (TIDM), an autoimmune disease. Although it often appears in childhood, T1DM may manifest at any age. The effects of T1DM can be devastating, as the disease often leads to significant secondary complications, morbidity, and decreased quality of life. Since the late 1960s, surgical treatment for diabetes mellitus has continued to evolve and has become a viable alternative to chronic insulin administration. In this review, the historical evolution, current status, graft efficacy, benefits, and complications of pancreas transplantation are explored.

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Tacrolimus in pancreas transplant: a focus on toxicity, diabetogenic effect and drug–drug interactions

Rangel

2014

Expert Opinion on Drug Metabolism & Toxicology

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Tacrolimus is a potent calcineurin inhibitor, an important pathway that regulates pancreatic development. Tacrolimus can induce β-cell apoptosis, decrease insulin exocytosis and reduce insulin gene transcription, which ultimately lead to impaired functional β-cell mass after pancreas transplant. Furthermore, insulin resistance can exacerbate the diabetogenic effect of tacrolimus due to inhibition of insulin gene transcription and β-cell proliferation. It is important to critically analyze the results of clinical studies and investigate new immunosuppressive drugs and/or novel drug combinations. It is equally important to comprehend and interpret experimental data. Therefore, minimization of side effects, based on safe approaches, can prolong pancreas allograft survival.

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The impact of pancreas and kidney transplant on cardiovascular risk factors (analyzed by mode of immunosuppression and exocrine drainage)

Abstract: SPK resulted in significant improvements both in glucose control and other measured CV risk factors.

Cited by 3 publications

References 21 publications

Cardiovascular Disease and Preventive Healthcare after Organ Transplantation

Cardiovascular Disease and Preventive Healthcare after Organ Transplantation

Evolution ofβ-Cell Replacement Therapy in Diabetes Mellitus: Pancreas Transplantation

Tacrolimus in pancreas transplant: a focus on toxicity, diabetogenic effect and drug–drug interactions

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