The impact of P/Ca molar ratio on physicochemical and release properties of calcium polyphosphate coacervates

Paiva, Juliana Moreno de; Barud, Hélida Gomes de Oliveira; Franco, Douglas F.; Meneguin, Andréía Bagliotti; Ribeiro, Antônio J.; Barud, Hernane S.; Nalin, Marcelo

doi:10.1016/j.matchemphys.2021.124471

Cited by 2 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phosphate entities can be either orthophosphate [195,212], pyrophosphate [213] or polyphosphate ions [192]. Among antimicrobial strategies, one can cite polyphosphate-based materials or coacervates [214][215][216][217] and amorphous calcium orthophosphates [218][219][220][221] with the possibility to associate both ortho-and pyrophosphates [222,223]. The tuneable ortho/(ortho+pyro) phosphate ratio could allow controlling the biological behaviour of these biomaterials, as it integrates benefits of both phosphate glasses (tuneable dissolution) and of amorphous CaP (synergistic effect of both molecular and ionic doping), allowing the direct combination with antimicrobial biomolecules or drugs.…”

Section: Amorphous Calcium and Phosphate-based Materialsmentioning

confidence: 99%

Biomaterial strategies to combat implant infections: new perspectives to old challenges

Braem

Kamarudin

Bhaskar

et al. 2023

International Materials Reviews

View full text Add to dashboard Cite

Peri-implant infection is rapidly becoming anif not the mostimportant clinical challenge for indwelling medical devices. To alleviate the global rise in antibiotic use for the treatment of such infections, a plethora of biomaterials/bioengineering-based antimicrobial strategies are emerging to restrict or ideally to eliminate microbial adhesion and biofilm formation on implant surfaces. Yet, the development of such approaches faces specific challenges, like biocompatibility concerns, reduced antimicrobial effectiveness, long-term stability issues and antibiotic resistance development, which limit translation to the clinic. This review provides insights into the antimicrobial activity of current state-of-the-art biomaterial-based approaches to address the aforementioned issues. Translational research strategies and regulatory framework are also emphasised as key elements facilitating clinical implementation of anti-infective biomaterials. This review closes with the vision that the integration of computational tools and experimental databases using artificial intelligence (AI) would provide new insights for the accelerated development of next-generation biomaterial-based antimicrobial strategies.

show abstract