The impact of oxytocin on neurite outgrowth and synaptic proteins in <i>Magel2</i>‐deficient mice

Reichova, Alexandra; Schaller, Fabienne; Bukatova, Stanislava; Bačová, Zuzana; Muscatelli, Françoise; Bakoš, Ján

doi:10.1002/dneu.22815

Cited by 21 publications

(19 citation statements)

References 59 publications

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“…171 The effects of oxytocin on glutamatergic system in the hippocampus. 159 and in the prefrontal cortex 172 have also been shown. Neurogenetic actions by oxytocin may also be involved in the long-lasting actions of early-life oxytocin.…”

Section: Long-term Effects Of Oxytocin Stimulation On the Brainmentioning

confidence: 80%

“…Postnatal daily administration of oxytocin (2 µg day -1 in the first 2 days or postnatal week) has been shown to increase pre-or post-synaptic transcript levels of neurexins and neuroligins 159 and to prevent deficits in social behaviour and learning abilities in adult Magel2-deficient mice, a mice model of Prader-Willi syndrome and autism spectrum disorder. 160 Intranasal oxytocin administration (200 µg kg -1 ) during postnatal days 7-21 has also been shown to restore the number of hypothalamic oxytocin neurons and to reverse social deficits in contactin-associated protein-like 2 (CNTNAP2)deficient mice, another model of autism spectrum disorder.…”

Section: Postnatal Oxytocin Stimulationmentioning

confidence: 99%

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The oxytocin system and early‐life experience‐dependent plastic changes

Onaka

Takayanagi

2021

J Neuroendocrinology

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Oxytocin is mostly synthesized within the hypothalamus and acts mainly on the oxytocin receptor that is expressed in the nervous system and peripheral organs. Oxytocin exerts not only reproduction-related functions such as delivery of children and milk ejection during the lactation period, but also various actions including control of stress-related responses, emotional responses and social behaviour. [1][2][3][4][5][6][7] The oxytocin receptor gene has single-nucleotide polymorphisms (SNPs) and SNPs of the oxytocin receptor gene have been shown to be associated with difference in pair bonding, 8 empathy and stress responsiveness, 9 generous

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Section: Long-term Effects Of Oxytocin Stimulation On the Brainmentioning

confidence: 80%

Section: Postnatal Oxytocin Stimulationmentioning

confidence: 99%

The oxytocin system and early‐life experience‐dependent plastic changes

Onaka

Takayanagi

2021

J Neuroendocrinology

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“…Rodents with MAGEL2 mutations provide an animal model through which PWS can be investigated. These animals exhibit a reduction in both hypothalamic oxytocin neurons and oxytocin receptors in brain areas involved in learning (e.g., the lateral septum) as well as abnormalities in oxytocin neuronal activity [ 250 , 252 , 253 , 254 ]. Moreover, MAGEL2 knockout mice show additional disrupted arcuate nucleus hypothalamic circuits, including a reduction in POMC-positive cells and α-MSH hormone axons which are critical to induce satiety [ 255 ].…”

Section: Interventional Studies Of Oxytocin Administration In Humansmentioning

confidence: 99%

The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans

Kerem

Lawson

2021

IJMS

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The hypothalamic peptide oxytocin and its receptor are involved in a range of physiological processes, including parturition, lactation, cell growth, wound healing, and social behavior. More recently, increasing evidence has established the effects of oxytocin on food intake, energy expenditure, and peripheral metabolism. In this review, we provide a comprehensive description of the central oxytocinergic system in which oxytocin acts to shape eating behavior and metabolism. Next, we discuss the peripheral beneficial effects oxytocin exerts on key metabolic organs, including suppression of visceral adipose tissue inflammation, skeletal muscle regeneration, and bone tissue mineralization. A brief summary of oxytocin actions learned from animal models is presented, showing that weight loss induced by chronic oxytocin treatment is related not only to its anorexigenic effects, but also to the resulting increase in energy expenditure and lipolysis. Following an in-depth discussion on the technical challenges related to endogenous oxytocin measurements in humans, we synthesize data related to the association between endogenous oxytocin levels, weight status, metabolic syndrome, and bone health. We then review clinical trials showing that in humans, acute oxytocin administration reduces food intake, attenuates fMRI activation of food motivation brain areas, and increases activation of self-control brain regions. Further strengthening the role of oxytocin in appetite regulation, we review conditions of hypothalamic insult and certain genetic pathologies associated with oxytocin depletion that present with hyperphagia, extreme weight gain, and poor metabolic profile. Intranasal oxytocin is currently being evaluated in human clinical trials to learn whether oxytocin-based therapeutics can be used to treat obesity and its associated sequela. At the end of this review, we address the fundamental challenges that remain in translating this line of research to clinical care.

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“…Although Prader-Willi syndrome is a multigene neurodevelopmental disorder with various physiological and behavioural deficits, the clinical characteristics include severe hypotonia, a newborn's poor feeding due to reduced suckling reflexes, childhood-onset obesity, lower cognitive functioning and autistic symptoms [83]. Magel2-deficient mice manifest altered gene and protein expression of PSD-95 in early brain developmental stages [5]. Magel2-deficient mice have shown altered levels of oxytocin in the hypothalamus, as well as 50% neonatal mortality due to suckling problems [84].…”

Section: Magel2 Genementioning

confidence: 99%

“…For instance, abnormal patterns of cell-adhesion molecules and scaffolding proteins, in association with altered neuronal morphology, have been observed in the "SH3 domain and ankyrin repeat containing protein 3" (Shank3) deficient mouse model [4]. Moreover, it has recently been demonstrated that altered expression of specific genes are involved in processes of neurite elongation and synapse formation in the early developmental periods of MAGE Family Member L2 (Magel2)-deficient mice [5], which is another model known for the presence of autismlike symptoms. Currently, it appears that crucial factors that play a role in the pathogenesis of autism are defects and abnormalities found in postsynaptic density proteins [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models

Meliskova¹,

Havránek²,

Bačová³

et al. 2021

Journal of Integrative Neuroscience

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Pathological changes in synapse formation, plasticity and development are caused by altered trafficking and assembly of postsynaptic scaffolding proteins at sites of glutamatergic and gammaaminobutyric acid synapses, suggesting their involvement in the etiology of neurodevelopmental disorders, including autism. Several autism-related mouse models have been developed in recent years for studying molecular, cellular and behavioural defects to understand the etiology of autism and test potential treatment strategies. In this review, the role of alterations in selected postsynaptic scaffolding proteins in relevant transgene autism-like mouse models is explained. A summary is also provided of selected animal models by paying special attention to interactions between guanylate kinases or membrane-associated guanylate kinases, as well as other synapse protein components which form functional synaptic networks. The study of early developmental stages of autism-relevant animal models help in the understanding the origin and development of diverse autistic symptomatology.

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The impact of oxytocin on neurite outgrowth and synaptic proteins in Magel2‐deficient mice

Cited by 21 publications

References 59 publications

The oxytocin system and early‐life experience‐dependent plastic changes

The oxytocin system and early‐life experience‐dependent plastic changes

The Effects of Oxytocin on Appetite Regulation, Food Intake and Metabolism in Humans

The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models

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