The impact of omega-3 fatty acids on lung histopathology in mice model of chronic asthma

Abstract

Article History

A systematic review of the association between fish oil supplementation and the development of asthma exacerbations

“…Bargut et al’s 12 study demonstrated a significantly reduced eosinophilic response in the OVA-exposed fish oil group when compared to the OVA-exposed control group. Eliaçik et al’s 14 study showed no significant difference in eosinophil concentration ratios between groups. Schuster et al’s 11 study showed that DHA, alone, produced significantly higher levels of bronchoalveolar lavage fluid (BALF) eosinophils than all other groups (p < 0.001), but did not show a significant difference in eosinophil levels between the control and the other n-3 PUFA groups.…”

“… 12 Miranda et al’s 10 rat model demonstrated a significant increase in static lung compliance in fish-oil supplemented, asthmatic rats (p < 0.05); however, there was no significant variation between the post-exposure groups in pulmonary smooth muscle force of contraction or smooth muscle layer thickness. Eliaçik et al’s 14 model found that basement membrane thickness was significantly lowered after fish oil supplementation (p = 0.038), but found no significant difference in goblet cell numbers or subepithelial smooth muscle thickness of airways between the groups. On comparing lung airway resistance, Schuster et al’s 11 study of varying formulations of EPA and DHA in mice showed that the sole-DHA diet produced significantly higher resistance measurements than all other groups.…”

“…Eosinophil infiltration levels were included in the mice studies by Bargut et al 12 (1.075 EPA:DHA ratio), Eliaçik et al 14 (2.5 EPA:DHA ratio), and Schuster et al 11 (DHA, only; EPA, only; and 1:1, EPA:DHA formulations) and by Brannan et al 17 in humans (2.0 EPA:DHA ratio). Bargut et al’s 12 study demonstrated a significantly reduced eosinophilic response in the OVA-exposed fish oil group when compared to the OVA-exposed control group.…”

“…Bargut et al 12 (1.075 EPA:DHA ratio), Miranda et al 10 (unreported EPA:DHA ratio), Eliaçik et al 14 (2.5 EPA:DHA ratio), and Schuster et al 11 (DHA, only; EPA, only; and 1:1, EPA:DHA formulations) all studied the components of the lung to determine the alterations post-exposure to an irritant to determine if the use of fish oil affected the composition of pulmonary structures. In Bargut et al’s 12 mice study, results showed a significant reduction in peribronchiolar matrix deposition post-antigen exposure (p = 0.0099).…”

Interaction of Asthma and Nutrition: Review

“…33 Araşidonik asit (AA), inflamasyon ve bağışıklık düzenlenmesinde önemli rollere sahip olan prostaglandin (PG)'ler, lökotrien (LT)'ler ve ilgili bileşiklerin ön maddesidir. 34 Omega 6 (n-6)'nın zengin kaynakları mısırözü yağı, zeytinyağı, aspur yağı, fındık yağı, ayçiçek yağı, pamuk yağı ve soya yağı-dır. 13 İnflamasyonu düzenleyen lipit mediyatörleri-nin çoğu n-6 ya da n-3 yağ asitlerinden elde edilmektedir.…”