The impact of ocular manifestations of rheumatoid arthritis on the health-related quality of life and the functional ability of black Africans

Akintayo, Richard Oluyinka; Adelowo, Olufemi; Egajifo, Ochuko; Popoola, Rukayyah Abisoye; Odunlami, Gbenga J; Emorinken, Airenakho; Olaosebikan, Babatunde Hakeem

doi:10.1007/s10792-018-0902-6

Cited by 11 publications

(20 citation statements)

References 30 publications

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“…Most of the patients in this study were educated as 74.4% of RA and 92.3% of SLE patients had at least primary school education. This is similar to the findings of the study by Akintayo et al ,[ 12 ] in which 96% of the patients had at least primary education. This may be attributable to the studies being tertiary hospital-based and the higher likelihood of educated people to seek health care in such facilities.…”

Section: Discussionsupporting

confidence: 92%

“…This may be due to Hausa being the predominant ethnic group in Zaria where the study was conducted. In comparison with the study by Akintayo et al [ 12 ] in Southwestern Nigeria, where majority of the patients were of Yoruba ethnicity at 68% and only 2% were of the Hausa ethnicity, this observed difference may be due to the fact that the Yorubas are the predominant ethnic group in Southwestern Nigeria.…”

Section: Discussioncontrasting

confidence: 77%

“…[ 10 11 ] Ophthalmic manifestations, which are pointers of active disease process and indicators of severe and potentially life-threatening systemic involvement,[ 7 ] have received little attention with very few studies done in Sub-Saharan Africa. [ 12 13 ] There is therefore the need to determine the spectrum of eye disorders in RA and SLE patients in Sub-Saharan Africa.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and spectrum of eye disorders among patients with rheumatoid arthritis and systemic lupus erythematosus in a tertiary hospital in Northern Nigeria

Muhammad

Abdullahi

Pam

et al. 2022

J West Afr Coll Surg

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Purpose: The aim of this study was to determine the spectrum of eye disorders in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Materials and Methods: A cross-sectional hospital-based study was conducted among 100 consecutive patients with RA and SLE. A semi-structured questionnaire was used to obtain details of patients’ sociodemographics, type of rheumatic disease, and prescribed medications. Each patient had a detailed examination of the anterior and posterior segments of the eye. Refraction, intraocular pressure measurement, Schirmer’s test, tear breakup time, gonioscopy, and dilated fundoscopy were also done. Fundus photograph, central visual field assessment, and optical coherence tomography were done as necessary. Analysis was done with the Statistical Package for Social Sciences (SPSS) version 25. Statistical significance was set at P < 0.05. Results: A total of 100 patients consisting of 74 RA and 26 SLE patients were evaluated. The female: male ratio was 4.3: 1 for RA, and all SLE patients were females. The prevalence of eye disorders was 42% in all patients; it was 41.9% and 42.3% among RA and SLE patients, respectively. The most common eye disorders were dry eye (38), refractive errors (18), and cataract (16). The mean age of RA patients with eye disorders (52.19 ± 16.17 years) was significantly higher than those without eye disorders (42.30 ± 13.14 years) ( P = 0.005). Conclusion: Eye disorders are common in RA and SLE. Comprehensive eye examination should be done on all RA and SLE patients at diagnosis and before commencement of medications, and patients should be referred promptly for evaluation when they have eye complaints.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

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Prevalence and spectrum of eye disorders among patients with rheumatoid arthritis and systemic lupus erythematosus in a tertiary hospital in Northern Nigeria

Muhammad

Abdullahi

Pam

et al. 2022

J West Afr Coll Surg

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“…RA is mainly considered as a joint disease, but it has the capacity to inflict multiple organs because of the abnormal systemic immune response. About 17.8–47.5% of patients present the extra-articular manifestations [ 12 , 13 ], among which the ocular surface manifestation is the most common [ 14 , 15 ], which seriously affects the quality of life [ 16 ]. Earlier studies have shown that synovitis is the pathological basis for joint injury in RA [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Study of Factors Influencing Dry Eye in Rheumatoid Arthritis

Wang

et al. 2020

Journal of Ophthalmology

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Purpose. The present study investigated the relationship between dry eye and the disease activity in patients with rheumatoid arthritis (RA). Methods. Patients with RA were divided by the Ocular Surface Disease Index (OSDI) into the symptomatic group (score ≥ 12) and the asymptomatic group (score < 12). By using the Disease Activity Score (DAS-28) questionnaire, they were divided into the active group (score > 2.6) and the stable group (score ≤ 2.6). In the control group, 20 healthy adults with matched sex and age were selected. RA patients and healthy adults were inspected for the tear film break time (TBUT), tear meniscus height (TMH), corneal fluorescein staining (CFS), meibomian scan (MS), meibomian gland secretion score (MSS), and eyelid margin assessment (EMS). Results. The TBUT of the RA group was significantly less than that of the control group, while the CFS, MS, EMS, and MSS were higher. The TBUT of the symptomatic RA group was significantly less than that of the asymptomatic group, and the CFS was higher. In the active RA group, only the CFS was higher than that of the stable group, and there was no significant difference between the two groups for other parameters. Furthermore, there was no significant correlation between the course of RA and the dry eye (P>0.05). Conclusion. The rheumatoid activity does not necessarily lead to an aggravation of dry eye. Regardless of the duration, RA was not found to exhibit relation with the severity of dry eye. Translational Relevance. RA patients with disease active period cannot be ignored for the existence of dry eye, since patients with dry eye often lack the signs and symptoms.

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“… 23 ) In patients with rheumatoid arthritis, it has been reported that ocular manifestations, including cataract, were associated with a significant negative impact on PCS. 24 ) In acute anterior uveitis, which is often associated with the HLA-B27 gene in patients with or without spondyloarthritis, the physical domain of SF-36 significantly deteriorated over 5 years. 25 ) Cataract could impair physical function in patients with musculoskeletal disorders; indeed, lower PCS scores were observed in SED patients with cataract than in those without cataract.…”

Section: Discussionmentioning

confidence: 99%

Health-related Quality of Life in Adult Patients with Multiple Epiphyseal Dysplasia and Spondyloepiphyseal Dysplasia

Matsushita

Mishima

Kamiya

et al. 2021

PRM

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Objectives: Multiple epiphyseal dysplasia (MED) and spondyloepiphyseal dysplasia (SED) are skeletal dysplasias associated with premature osteoarthritis and short stature. Patients with SED often have spinal and ocular problems. Few reports have focused on the health-related quality of life (HRQoL) of patients with skeletal dysplasias associated with premature osteoarthritis. The purpose of this study was to evaluate the HRQoL of adult patients with MED and SED. Methods: Questionnaires covering demographics, medical history (cataract, retinal detachment, and osteoarthritis), surgical history (osteotomy and arthroplasty), and the Short Form-36 (SF-36) health survey were sent to all patients with MED and SED with medical records at the investigators’ institutions. Among the 27 patients who completed the questionnaire, patients aged 20 years or older were included in this cohort. Results: The subjects were 18 affected individuals. The physical component summary score (PCS) was significantly lower in the MED and SED groups than in the normal population and tended to deteriorate with age. Conversely, there was a positive correlation between the mental component summary score and age. The role/social component summary score was not correlated with age. MED patients with osteoarthritis had a low PCS. PCS was particularly low in two SED patients with a medical history of cataract, whereas there was no association with a history of retinal detachment or osteoarthritis. Conclusions: The physical domain of HRQoL in MED and SED patients significantly deteriorated at a young age. Appropriate medical management of these skeletal dysplasias is required not only for orthopedic functions but also for ocular problems.

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The impact of ocular manifestations of rheumatoid arthritis on the health-related quality of life and the functional ability of black Africans

Abstract: The development of ocular disorders associated with RA is associated with a significant negative impact on the quality of life of the patients.

Cited by 11 publications

References 30 publications

Prevalence and spectrum of eye disorders among patients with rheumatoid arthritis and systemic lupus erythematosus in a tertiary hospital in Northern Nigeria

Prevalence and spectrum of eye disorders among patients with rheumatoid arthritis and systemic lupus erythematosus in a tertiary hospital in Northern Nigeria

Study of Factors Influencing Dry Eye in Rheumatoid Arthritis

Health-related Quality of Life in Adult Patients with Multiple Epiphyseal Dysplasia and Spondyloepiphyseal Dysplasia

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