The impact of occupational exposure to crystalline silica dust on respiratory function (airway obstruction and FEF25-75) in the French general population

Wardyn, Pierre-Marie; Edmé, Jean-Louis; Broucker, Virginie de; Chérot‐Kornobis, Nathalie; Ringeval, David; Amouyel, Philippe; Sobaszek, Annie; Dauchet, Luc; Hulo, Sébastien

doi:10.1016/j.envres.2023.115382

Cited by 4 publications

(5 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given the complex detrimental effects of particulate and irritant gaseous constituents of smoking on COPD, there is high biological plausibility that other inhaled toxins, e.g., respirable crystalline silica, also have an etiological role in the progression of this disease and thus increase the risk of incidence [ 6 , 7 ]. In fact, high prevalence of airflow obstruction (44% in ever smokers and 30% in never smokers) has been reported in a surveillance study of 1048 workers with silica exposure in Michigan [ 8 ], and higher likelihood of having airflow obstruction (OR = 3.06, 95% CI: 1.11–7.63) was also observed in the ELISABET study in French [ 9 ]. It is plausibly hypothesized that the harmful effect of smoking on the development of COPD in the workers with dust exposures may be worse than that in the general population [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 80%

Association of smoking cessation with airflow obstruction in workers with silicosis: A cohort study

Yang,

Chan,

Wang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Background Studies in general population reported a positive association between tobacco smoking and airflow obstruction (AFO), a hallmark of chronic obstructive pulmonary disease (COPD). However, this attempt was less addressed in silica dust-exposed workers. Methods This retrospective cohort study consisted of 4481 silicotic workers attending the Pneumoconiosis Clinic during 1981–2019. The lifelong work history and smoking habits of these workers were extracted from medical records. Spirometry was carried out at the diagnosis of silicosis (n = 4177) and reperformed after an average of 9.4 years of follow-up (n = 2648). AFO was defined as forced expiratory volume in one second (FEV1)/force vital capacity (FVC) less than lower limit of normal (LLN). The association of AFO with smoking status was determined using multivariate logistics regression, and the effect of smoking cessation on the development of AFO was evaluated Cox regression. Results Smoking was significantly associated with AFO (current smokers: OR = 1.92, 95% CI 1.51–2.44; former smokers: OR = 2.09, 95% CI 1.65–2.66). The risk of AFO significantly increased in the first 3 years of quitting smoking (OR = 1.23, 95% CI 1.02–1.47) but decreased afterwards with increasing years of cessation. Smoking cessation reduced the risk of developing AFO no matter before or after the confirmation of silicosis (pre-silicosis cessation: HR = 0.58, 95% CI 0.46–0.74; post-silicosis cessation: HR = 0.62, 95% CI 0.48–0.79). Conclusions Smoking cessation significantly reduced the risk of AFO in the workers with silicosis, although the health benefit was not observed until 3 years of abstinence. These findings highlight the importance of early and long-term smoking cessation among silicotic or silica dust-exposed workers.

show abstract

Section: Introductionmentioning

confidence: 80%

Association of smoking cessation with airflow obstruction in workers with silicosis: A cohort study

Yang,

Chan,

Wang

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…The study participants were men and women aged 40 to 65 having participated in the ELISABET ( Enquête Littoral Souffle Air Biologie Environnement ) cross-sectional study between January 2011 and November 2013. The methodology of the ELISABET study has been described in detail elsewhere [ 6 , 7 ]. Briefly, all the participants had lived in the same city or the surrounding urban area (either Lille or Dunkirk) for at least the 5 years immediately prior to inclusion.…”

Section: Methodsmentioning

confidence: 99%

“…We also excluded subjects for whom exposure to crystalline silica could not be estimated. Following recent regulatory changes concerning data protection, information concerning the re-use of data was sent to participants of the ELISABET study, resulting in the exclusion of 89 additional subjects compared with our previous publication [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…Participants were identified as exposed to crystalline silica for a given time period when the combination of their professional code and their company’s economic activity code was found in Matgéné Silice job-exposure matrix created by Santé Publique France [ 8 ]. The methodology for occupational exposure assessment has been detailed elsewhere [ 6 ].…”

Section: Methodsmentioning

confidence: 99%

“…Indeed, the data currently available is limited by the census years and only provides a description of the sectors of activity for the year 2017 [ 5 ]. Our team recently highlighted the importance of monitoring silica exposure on respiratory function [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Occupational exposure to crystalline silica in a sample of the French general population

Wardyn,

Edme,

de Broucker

et al. 2024

J Occup Med Toxicol

Self Cite

View full text Add to dashboard Cite

Objective To describe the proportions of subjects exposed to crystalline silica and the sectors of activity concerned between 1965 and 2010 in a sample of the general French population. Methods We included 2942 participants aged 40 to 65 years, recruited at random from electoral rolls, from the French general population in the cross-sectional ELISABET study between 2011 and 2013. The proportions of subjects exposed to crystalline silica and their sectors of activity were determined on the basis of their career history and the use of the Matgéné job-exposure matrix. Results In the total sample, occupational exposure to crystalline silica was found for 291 subjects (9.9%) between 1965 and 2010, with a predominance of men (20.2% of exposed subjects among men (282 out of 1394) versus 0.6% among women (9 out of 1548)). The highest proportion of participants exposed to crystalline silica was reached in 1980 with 6.1% and then decreases to 4.4% in 2010. Among men, the most frequently exposed sectors of activity were manufacture of basic metals (41.5% of exposed men (117 out of 282)), specialised construction activities (23.1% of exposed men (65 out of 282)) and construction of buildings (14.2% of exposed men (40 out of 282)). Conclusions Although the proportion of workers exposed to crystalline silica has been decreasing since the 1980s, it is still significant at least until 2010, particularly in the construction sector, and further research is needed to improve the monitoring of workers who are or have been exposed to crystalline silica.

show abstract

Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming

Li,

Ling,

et al. 2024

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

The impact of occupational exposure to crystalline silica dust on respiratory function (airway obstruction and FEF25-75) in the French general population

Cited by 4 publications

References 41 publications

Association of smoking cessation with airflow obstruction in workers with silicosis: A cohort study

Association of smoking cessation with airflow obstruction in workers with silicosis: A cohort study

Occupational exposure to crystalline silica in a sample of the French general population

Paracrine signaling of ferroptotic airway epithelium in crystalline silica-induced pulmonary fibrosis augments local fibroblast activation through glycolysis reprogramming

Contact Info

Product

Resources

About