The impact of obstructive sleep apnea on high-sensitivity C-reactive protein in subjects with or without metabolic syndrome

Wu, Wei‐Te; Tsai, Su-Shan; Shih, Tung‐Sheng; Lin, Ming-Hsiu; Chou, Tzu-Chieh; Ting, Hua; Wu, Trong-Neng; Liou, Saou-Hsing

doi:10.1007/s11325-015-1166-2

Cited by 14 publications

(15 citation statements)

References 29 publications

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“…Out of the included studies, the mean age for the samples ranged from 38.5 to 66 on OSA group, and 42.9 to 66 controls. Diagnostic methods we used for evaluating tobacco, alcohol and caffeine in the studies were questionnaire, and in other not report studies . Each study used specific AHI values for OSA definition through PSG.…”

Section: Resultsmentioning

confidence: 99%

Association between obstructive sleep apnea and alcohol, caffeine and tobacco: A meta‐analysis

Taveira

Kuntze

Berretta

et al. 2018

J of Oral Rehabilitation

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The aim of this systematic review was to answer the focused question, "Is there an association between obstructive sleep apnea (OSA) and alcohol, caffeine or tobacco use?" Five electronic databases (Cinahl, Literatura Latth American and Caribbean, PubMed, Scopus, Web of Science) and 3 grey literature (Google Acadêmico, ProQuest, OpenGrey) were searched, as well as search on reference list of included papers and contacts with study authors. Observational studies were included. The Meta-Analysis of Statistics Assessment and Review Instrument (MAStARI) tool assessed the potential risk of bias (RoB) among the studies, while the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach determined the level of evidence. Meta-Analysis was performed with RevMan 5.3 software. Among 3,442 identified studies, 14 were included. Eleven studies were classified as moderate RoB and 3 as high RoB. Meta-analysis showed OSA has no association with tobacco and presented a positive association with alcohol. The odds ratio for OSA increased almost 1.33 times (95% confidence interval [CI]; 1.10-1.62) for alcohol users. There was insufficient published data to evaluate whether OSA is associated with caffeine. The overall quality of evidence ranged from low to very low. OSA was associated with the use of alcohol, however there is not enough evidence to confirm the association with tobacco or caffeine. Due to the very low GRADE level of evidence, caution should be applied when considering these findings.

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Section: Resultsmentioning

confidence: 99%

Association between obstructive sleep apnea and alcohol, caffeine and tobacco: A meta‐analysis

Taveira

Kuntze

Berretta

et al. 2018

J of Oral Rehabilitation

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“…In OSA, there are arguments in favour of chronic inflammation, which may be correlated with the severity of OSA [32, 33] and which may result in higher plasma levels of CRP [57]. Despite the special relationship between chronic inflammation and OSA, plasma CRP levels have never been studied as a risk factor for OSA in the general population or insomnia sufferers.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, in OSA, there are arguments that the presence of chronic systemic inflammation results in higher levels of C-reactive protein (CRP) [31]. In addition, OSA severity is correlated with the markers of this chronic inflammation [32, 33], but have never been studied as a predictor of OSA. Moreover, these various risk factors have never been studied for moderate to severe OSA in insomnia sufferers.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects

et al. 2017

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BackgroundSeveral studies have investigated the prevalence and risk factors of insomnia in subjects with obstructive sleep apnea syndrome. However, few studies have investigated the prevalence and risk factors for obstructive sleep apnea syndrome in insomnia sufferers. Thus, the aim of this study was to examine the prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in a large sample of insomnia sufferers.MethodsData from 1311 insomnia sufferers who were recruited from the research database of the sleep laboratory of the Erasme Hospital were analysed. An apnea-hypopnea index of ≥15 events per hour was used as the cut-off score for moderate to severe obstructive sleep apnea syndrome. Logistic regression analyses were conducted to examine clinical and demographic risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers.ResultsThe prevalence of moderate to severe obstructive sleep apnea syndrome in our sample of insomnia sufferers was 13.88%. Multivariate logistic regression analysis revealed that male gender, snoring, excessive daytime sleepiness, lower maintenance insomnia complaint, presence of metabolic syndrome, age ≥ 50 & <65 years, age ≥ 65 years, BMI ≥ 25 & <30 kg/m2, BMI >30 kg/m2, and CRP >7 mg/L were significant risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers.ConclusionModerate to severe obstructive sleep apnea syndrome is a common pathology in insomnia sufferers. The identification of these different risk factors advances a new perspective for more effective screening of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers.

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“…Low‐grade inflammation has been reported to be associated with an astounding number of conditions and lifestyles felt to be associated with poor health; these conditions represent or reflect minor metabolic stresses. The lengthy (partially cited here) list includes exposure to environmental irritants such as cigarettes, secondhand smoke, sleep deprivation, low levels of physical activity, atrial fibrillation, hypertension, low birth weight, lumbar disc herniation, impaired cognition, low grip strength, polycystic ovary syndrome, living at high altitude (12, 13), prehypertension (14), obstructive sleep apnea (15), premenstrual symptoms (16), a large variety of unhealthy diets (17), hypoxia (18), social isolation (19, 20), being unmarried (21), and aging (22, 23).…”

Section: Low‐grade Inflammationmentioning

confidence: 99%

It's time to redefine inflammation

2017

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Inflammation has been defined for many years as the response to tissue injury and infection. We are now forced to reconsider this definition by the avalanche of reports that molecules and cells associated with inflammation are activated or expressed in high concentration in a large variety of states in the absence of tissue injury or infection. Modest increases in concentration of C-reactive protein, a circulating marker of inflammation, have been reported to be associated with an astounding number of conditions and lifestyles felt to be associated with poor health; these conditions represent or reflect minor metabolic stresses. In recent years we have learned that inflammation is triggered by sentinel cells that monitor for tissue stress and malfunction-deviations from optimal homeostasis-and that molecules that participate in the inflammatory process play a role in restoring normal homeostasis. Accordingly, we suggest that inflammation be redefined as the innate immune response to potentially harmful stimuli such as pathogens, injury, and metabolic stress.-Antonelli, M., Kushner, I. It's time to redefine inflammation.

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The impact of obstructive sleep apnea on high-sensitivity C-reactive protein in subjects with or without metabolic syndrome

Abstract: Elevated hs-CRP level is associated with severe OSA, independent of known confounders. The effect of OSA in CRP is independent of MetS was identified.

Cited by 14 publications

References 29 publications

Association between obstructive sleep apnea and alcohol, caffeine and tobacco: A meta‐analysis

Association between obstructive sleep apnea and alcohol, caffeine and tobacco: A meta‐analysis

Prevalence and risk factors of moderate to severe obstructive sleep apnea syndrome in insomnia sufferers: a study on 1311 subjects

It's time to redefine inflammation

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