The Impact of Obesity on Diabetes Onset and Neovascularization in Mouse Models of Metabolic Stress
Sai Pranathi Meda Venkata,
Hainan Li,
Liping Xu
et al.
Abstract:Animal models of metabolic disorders are essential to studying pathogenic mechanisms and developing therapies for diabetes, but the induction protocols vary, and sexual dimorphism often exists. In a chronic diabetic model of diet-induced obesity (DIO) and low-dose streptozotocin (STZ)-induced hyperglycemia, blood glucose and lipid profiles were measured. The high-fat (HF) diet damaged insulin sensitivity and increased triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, and liver lipid depositio… Show more
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